Effect of Wave Reflection and Arterial Stiffness on the Risk of Development of Hypertension in Japanese Men

Tomiyama, Hirofumi; Komatsu, Shunsuke; Shiina, Kazuki; Matsumoto, Chisa; Kimura, Kana; Fujii, Masatsune; Takahashi, Lisa; Chikamori, Taishiro; Yamashina, Akira

doi:10.1161/jaha.117.008175

Cited by 19 publications

(19 citation statements)

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“…End of the study period was defined by the last examination of the participants who had undergone at least 2 annual examinations. 8,9 Among the whole study subjects included, 474 (14.5%) developed hypertension (of which 152 were already receiving antihypertensive medication by the end of the study period) by the end of the study period. The mean number of times that the variables were measured was 5.2±2.1×, and the mean duration of follow-up was 6.4±2.5 years.…”

Section: Discussionmentioning

confidence: 99%

“…8,9 The cohort consisted of employees working at the headquarters of a single large Japanese construction company located in downtown Tokyo. According to the Occupational Health and Safety Law in Japan, it is mandatory for all company employees to undergo annual health checkups.…”

Section: Design and Subjectsmentioning

confidence: 99%

“…[8][9][10] Briefly, occlusion cuffs connected to both the plethysmographic and oscillometric sensors were tied around both the upper arms and lower legs of the subjects lying in the supine position. The brachial and post-tibial arterial pressures were measured by the oscillometric sensor.…”

Section: Measurement Of the Bapwvmentioning

confidence: 99%

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Involvement of Arterial Stiffness and Inflammation in Hyperuricemia-Related Development of Hypertension

et al. 2018

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A ccording to recently reported meta-analyses, hyperuricemia is an independent risk factor for the development of hypertension, 1,2 although the underlying mechanisms have not yet been fully clarified. Hyperuricemia has also been reported to be associated with the early stages of development of some risk factors for hypertension, such as arterial stiffness, 3 renal function decline, 4 and inflammation. 5 Thus, we attempted to verify the possibility of involvement of these risk factors in the risk of development of hypertension associated with hyperuricemia. 6 Although an observational study would be needed for such an objective, conventional observational studies, in which the relevant assessments are conducted at 2 observational points, have the limitation that they exclude the effects of timevarying confounding variables.7 However, analysis of repeated measures data by mixed model linear (MML) regression analysis and general estimated equation (GEE) analysis may be useful to minimize the effects of time-varying confounders. In the present prospective observational study conducted in Japanese men without hypertension at the study baseline, we analyzed repeated measures data by MML regression analysis and GEE analysis to clarify the longitudinal associations of hyperuricemia with the above-mentioned risk factors for the development of hypertension, and then to examine the longitudinal associations of these risk factors with the development of hypertension. MethodsThe data, analytical methods, and study materials will not be made available to other researchers for the purpose of reproducing the results or replicating the procedure. Design and SubjectsThe present study was conducted in the same cohort as that used in a previously reported prospective observational study. 8,9 The cohort consisted of employees working at the headquarters of a single large Japanese construction company located in downtown Tokyo. According to the Occupational Health and Safety Law in Japan, it is mandatory for all company employees to undergo annual health checkups. Informed consent for participation in this study was obtained from all of the study participants before their enrollment in this study. The study was Correspondence to Hirofumi Tomiyama, Department of Cardiology, Tokyo Medical University, 6-7-1 Nishi-Shinjuku, Tokyo 160-0023, Japan. Email tomiyama@tokyo-med.ac.jp See Editorial Commentary, pp 582-584Abstract-This study analyzed repeated measurement data to clarify the longitudinal associations between hyperuricemia and the risk factors for the development of hypertension (ie, increased arterial stiffness, renal dysfunction, and inflammation), and then examined whether these risk factors show longitudinal associations with the development of hypertension. In 3274 Japanese men without hypertension, the brachial-ankle pulse wave velocity, blood pressure, estimated glomerular filtration rate, and serum uric acid and CRP (C-reactive protein) levels were measured annually over an 8-year period. Of these, 474 subjects developed hy...

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Section: Discussionmentioning

confidence: 99%

Section: Design and Subjectsmentioning

confidence: 99%

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Involvement of Arterial Stiffness and Inflammation in Hyperuricemia-Related Development of Hypertension

et al. 2018

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“…In particular, for arterial stiffness, it is one of the earliest recognized markers of hypertension and plays an important role in the development and prognosis of hypertension. It is reported that arterial stiffness makes an important contribution to the increase in systolic blood pressure (SBP) and the development of hypertension in general population, independently of traditional hypertension risk factors [9][10][11][12][13][14][15]. Besides, changes in both small and large arteries could predict future hypertension.…”

Section: Introductionmentioning

confidence: 99%

Radial Pulse Wave Signals Combined with Ba-PWV for the Risk Prediction of Hypertension and the Monitoring of Its Accompanying Metabolic Risk Factors

Zhao

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Our aim was to study whether radial pulse wave signals can improve the risk prediction of incident hypertension and are associated with its concomitant metabolic risk factors beyond the traditional cardiovascular risk factor Ba-PWV. By enrolling 523 Chinese subjects in this study, linear and stepwise regression analysis was performed to assess the association of radial artery pulse wave signals and Ba-PWV with blood pressure and its related metabolic risk factors such as fasting plasma glucose (FPG), total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and uric acid (UA). The area under the receiver-operating characteristic curve (AUC), net reclassification improvement (NRI), and integrated discrimination improvement (IDI) were calculated by risk assessment plot to compare the discriminative ability among models with and without radial artery pulse wave signals. After adjusting related confounding factors, radial artery pulse wave variable h3/h1 was selected as the sensitive influential factor for blood pressure. Moreover, a new model with h3/h1 had a higher AUC than the reference model without it (0.86 vs 0.84; P=0.030). And the NRI and IDI for the new model was 50.0% (P=0.017) and 3.16% (P=0.044), respectively. In addition to Ba-PWV, we found that the decrease of t4, t5, and h5 might be associated with higher FPG, TC, LDL-C, and UA and lower HDL-C. This research might provide a valuable additional tool for remote wearable monitoring of radial artery pulse wave signals in hypertension risk evaluation and management.

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“…Currently, because of its reproducibility and simplicity [6, 7], brachia–ankle pulse wave velocity (baPWV) is a widely used method for assessing arterial stiffness in studies of large sample sizes [7]. baPWV was found to be related to increased risk of stroke [8], total cardiovascular events and all-cause mortality [9], and was shown to positively associated with hypertension [10] and the presence of coronary calcium [11] or left ventricular mass [12]. Nevertheless, there are limited studies on baPWV and diabetes.…”

Section: Introductionmentioning

confidence: 99%

Positive association between baseline brachial–ankle pulse wave velocity and the risk of new-onset diabetes in hypertensive patients

Zhang

et al. 2019

Cardiovasc Diabetol

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Background There is no clearly defined temporal relationship between arterial stiffness and diabetes. We aimed to investigate the prospective association between baseline brachial–ankle pulse wave velocity (baPWV) and the risk of new-onset diabetes during follow-up, and examined whether there were effect modifiers, in hypertensive patients. Methods We included 2429 hypertensive patients with all the pertinent data but without diabetes at the baseline, who were part of the China Stroke Primary Prevention Trial (CSPPT), a randomized, double-blind, actively controlled trial conducted in 32 communities in Anhui and Jiangsu provinces in China. The primary outcome was new-onset diabetes, defined as physician-diagnosed diabetes or use of glucose-lowering drugs during follow-up, or fasting glucose (FG) ≥ 126.0 mg/dL at the exit visit. Results During a median follow-up duration of 4.5 years, 287 (11.8%) participants developed diabetes. There was a significant positive association between baseline baPWV and the risk of new-onset diabetes (per SD increment; OR, 1.33; 95% CI 1.13, 1.56). Consistently, when baPWV was assessed as quartiles, a significantly higher risk of new-onset diabetes was found in participants in quartiles 2–4 (≥ 15.9 m/s; OR, 1.80; 95% CI 1.22, 2.65) compared with those in quartile 1 (< 15.9 m/s). The positive association was consistent in participants with (per SD increment; OR, 1.29; 95% CI 1.06, 1.56) or without (per SD increment; OR, 1.40; 95% CI 1.15, 1.71) impaired fasting glucose (IFG, FG ≥ 100.8 and < 126.0 mg/dL, P -interaction = 0.486). Conclusions In this sample of hypertensive patients, we found a significant positive association between baseline baPWV and the risk of new-onset diabetes. Clinical trial registration Trial registration: NCT00794885 (clinicaltrials.gov). Retrospectively registered November 20, 2008

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Effect of Wave Reflection and Arterial Stiffness on the Risk of Development of Hypertension in Japanese Men

Cited by 19 publications

References 20 publications

Involvement of Arterial Stiffness and Inflammation in Hyperuricemia-Related Development of Hypertension

Involvement of Arterial Stiffness and Inflammation in Hyperuricemia-Related Development of Hypertension

Radial Pulse Wave Signals Combined with Ba-PWV for the Risk Prediction of Hypertension and the Monitoring of Its Accompanying Metabolic Risk Factors

Positive association between baseline brachial–ankle pulse wave velocity and the risk of new-onset diabetes in hypertensive patients

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