Synergistic Effect of Silver Nanoparticles Combined With Different Antibiotics Against Multidrug-Resistant Acinetobacter Baumannii Strain H72721

Sabir, Dana Khdr

doi:10.31530/17028

Cited by 4 publications

(1 citation statement)

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“…The antibiotic susceptibility test was carried out as previously described (18). Briefly, the A. baumanii strain H72721was grown in 50 ml TSB medium with shaking at 30°C.…”

Section: Determination Of Minimal Inhibitory Concentration (Mic)mentioning

confidence: 99%

Antimicrobial Activity of Combined Cinnamon Nanoemulsions-Antibiotics against Acinetobacter baumannii

Sabir¹,

Sidiq²

2019

PJBAS

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Threats of Acinetobacter baumannii, a Gram-negative and multi-drug resistant bacterium, to the public health have recently received great attention worldwide. This is because the high incidence rate of the bacterial infections and the ability of the A. baumannii to resist a wide range of antibiotics. This study is designed to investigate the antimicrobial activity of the cinnamon oil in water as Nano emulsions (NEs) alone and in combination with different antibiotics against clinical isolate of A. baumannii. At the beginning, the minimum inhibitory concentration (MIC) of different antibiotics and also cinnamon Nano emulsions (CNEs) are determined. Later, the synergistic effect of the CNEs with each of the studied antibiotics is also examined. Results showed that the bacterium has the highest resistant towards ampicillin (MIC = 700 µg/ml), followed by kanamycin, and gentamycin with MIC of each of the antibiotics was 200µg/ml and 150 µg/ml, respectively. Cinnamon Nano emulsions (CNEs) were also showed a profound inhibitory effect on A. baummanii. Interestingly, combinations of cinnamon Nano emulsions (CNEs) with either kanamycin or gentamycin, but not ampicillin, show a significant increase in the antimicrobial activity of each of the antibiotics compared to when they were used alone. The results of this study strongly suggest the potential application of CNEs in combination with antibiotics to overcome A. baummanii infections.

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“…The antibiotic susceptibility test was carried out as previously described (18). Briefly, the A. baumanii strain H72721was grown in 50 ml TSB medium with shaking at 30°C.…”

Section: Determination Of Minimal Inhibitory Concentration (Mic)mentioning

confidence: 99%

Antimicrobial Activity of Combined Cinnamon Nanoemulsions-Antibiotics against Acinetobacter baumannii

Sabir¹,

Sidiq²

2019

PJBAS

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Synergistic Effects Between Metal Nanoparticles and Commercial Antimicrobial Agents: A Review

Ribeiro

Dias

Zille

2022

ACS Appl. Nano Mater.

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Nanotechnology has expanded into a broad range of clinical applications. In particular, metal nanoparticles (MNPs) display unique antimicrobial properties, a fundamental function of novel medical devices. Combining MNPs with commercial antimicrobial drugs (e. g., antibiotics, antifungals and antivirals) may offer several opportunities to overcome some disadvantages of their individual use and enhance effectiveness. MNPs-conjugates display multiple advantages. As drug delivery systems, the conjugates can extend the circulation of the drugs in the body, facilitate intercellular targeting, improve drug stabilization, and possess superior delivery. Concomitantly, they reduce the required drug dose, minimize toxicity and broaden the antimicrobial spectrum. In this work, the common strategies to combine MNPs with clinically used antimicrobial agents are underscored. Furthermore, a comprehensive survey about synergistic antimicrobial effects, mechanism of action and cytotoxicity is depicted. SilverAntimicrobial, drug deliver, anticancer, anti-angiogenic and biosensors 46,47 Gold Drug delivery, catalyst for medical therapy, antimicrobial conjugations, anticancer, gene therapy and diagnostic 48,49 Copper and copper oxide Antimicrobial and catalysis 50, 51 Iron and iron oxideAnticancer therapy, magnetic resonance imaging, targeted drug delivery and cell separation catalysis [52][53][54] Zinc oxide Personal care products, coatings, drug delivery, anticancer and antimicrobial 55, 56Aluminum oxide Drug delivery, biosensing, cancer therapy, antimicrobial, biomolecular preservation, immunotherapy 57 Titanium oxideDrug delivery, photodynamic therapy, cell imaging, biosensors, and genetic engineering, antimicrobial 58,59 Platinum Biomedical devices, anticancer therapies, cardiovascular diseases, bioimaging, nanozymes, biosensors, antimicrobial 60, 61 PalladiumPhotothermal agents, photoacoustic agents, antimicrobial, anticancer, gene/drug carriers, prodrug activators and biosensors 62,63 Scheme 1. MNPs used in biomedical applications. Silver Nanoparticles (AgNPs)AgNPs are the most prevalent inorganic nanoparticles applied as antimicrobial agent. AgNPs have demonstrated high antimicrobial activity comparable to Ag ionic form. However, several concerns have emerged regarding their cytotoxicity. The toxicity mechanisms, long-term accumulation effects and dose-response relationship are still grievously unknown. 64 Gold Nanoparticles (AuNPs)AuNPs are extremely valuable in developing antibacterial agents due to their low toxicity, high propensity for functionalization, eclectic effects, easy detection and photothermal activity. AuNPs per se possess very low antimicrobial activity, but numerous studies on the antimicrobial activity of AuNPs conjugated with small molecules, such as drugs, vaccines and antibodies, have been reported.

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Antimicrobial Activity of Silver Nanoparticles with Antibiotics Against Clinically Isolated Acinetobacter baumannii

Mohamedsalih¹,

Sabir²

2020

passer

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Synergistic Effect of Silver Nanoparticles Combined With Different Antibiotics Against Multidrug-Resistant Acinetobacter Baumannii Strain H72721

Cited by 4 publications

References 0 publications

Antimicrobial Activity of Combined Cinnamon Nanoemulsions-Antibiotics against Acinetobacter baumannii

Antimicrobial Activity of Combined Cinnamon Nanoemulsions-Antibiotics against Acinetobacter baumannii

Synergistic Effects Between Metal Nanoparticles and Commercial Antimicrobial Agents: A Review

Antimicrobial Activity of Silver Nanoparticles with Antibiotics Against Clinically Isolated Acinetobacter baumannii

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