Synergistic effect of nicorandil and amlodipine on mitochondrial function during isoproterenol-induced myocardial infarction in rats

Sathish, Venkatachalem; Vimal, V.; Ebenezar, Kesavarao Kumar; Devaki, Thiruvengadam

doi:10.1211/0022357021771841

Cited by 36 publications

(14 citation statements)

References 31 publications

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“…It has been reported that these enzymes are released from the heart into blood stream, thus increasing their concentration in serum (Wexler and Kittinger, 1963;Sathish et al, 2002;Deepa and Varalakshmi, 2003). In the present study, marked elevation in the activities of these enzymes in the serum of adriamycin intoxicated rats were observed.…”

Section: Discussionsupporting

confidence: 62%

Protective effect of Centella asiatica on antioxidant tissue defense system against adriamycin induced cardiomyopathy in rats

et al. 2004

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Section: Discussionsupporting

confidence: 62%

Protective effect of Centella asiatica on antioxidant tissue defense system against adriamycin induced cardiomyopathy in rats

et al. 2004

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“…A significant decrease in the activities of antiperoxidative enzymes, SOD and CAT may be due to diminished scavenging of HO • formed by ISO-induced lipid peroxidation. 37 A decrease in the activity of GPx makes mitochondria susceptible to ISO-induced myocardial damage that leads to mitochondrial dysfunction. 38 The decrease in the activities of GPx and GST may be due to a reduced availability of their substrate, GSH.…”

Section: Discussionmentioning

confidence: 99%

Protective effect of morin on cardiac mitochondrial function during isoproterenol-induced myocardial infarction in male Wistar rats

et al. 2012

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Altered mitochondrial function and free radical-mediated tissue damage have been suggested as an important pathological event in isoproterenol (ISO)-induced cardiotoxicity. This study was undertaken to know the preventive effect of morin on mitochondrial damage in ISO-induced cardiotoxicity in male Wistar rats. Myocardial infarction (MI) in rats was induced by ISO (85 mg/kg) at an interval of 24 hours for 2 days. Morin was given to rats as pre-treatment for 30 days orally using an intragastric tube. ISO-treated rats showed a significant elevation of mitochondrial thiobarbituric acid reactive substances (TBARS) and hydrogen peroxide (HP) level and pre-treatment with morin significantly prevented the increase of TBARS and HP level to near normality. The level of enzymic and non-enzymic antioxidants was decreased significantly in ISO-treated rats and pre-treatment with morin significantly increased the levels of superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase, glutathione reductase, and reduced glutathione to normality. The activities of mitochondrial enzymes such as isocitrate dehydrogenase, alpha-ketoglutarate dehydrogenase, succinate dehydrogenase, and malate dehydrogenase were decreased significantly in ISO-treated myocardial ischemic rats and upon pre-treatment with morin restored these enzymes activity to normality. In addition, the decreased activities of cytochrome-C oxidase and NADH-dehydrogenases were observed in ISO-treated rats and pre-treatment with morin prevented the activities of cytochrome-C oxidase and NADH-dehydrogenase to normality. Pre-treatment with morin favorably restored the biochemical and functional parameters to near normal indicating morin to be a significant protective effect on cardiac mitochondrial function against ISO-induced MI in rats.

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“…et al . [2627] Vascular reactivity to NA, Adr, AngII and 5-HT was measured by invasive blood pressure technique in all groups of rats, as described earlier by Balaraman et al . Endogenous enzymes such as catalase and superoxide dismustase are the first line cellular defense free radical scavenging enzymes against oxidative injury.…”

Section: Discussionmentioning

confidence: 99%

Cardioprotective potential of Punica granatum extract in isoproterenol-induced myocardial infarction in Wistar rats

Mohan¹,

Patankar²,

Ghadi³

et al. 2010

Journal of Pharmacology and Pharmacotherapeutics

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Objective:To determine the protective role of Punica granatum L. (Punicaceae) seed juice extract and its butanolic fraction on heart rate, electrocardiographic patterns, vascular reactivity to catecholamines, cardiac marker enzymes, antioxidant enzymes together with morphologic and histopathological changes in isoproterenol-induced myocardial infarction in male Wistar rats.Materials and Methods:The effects of Punica granatum seed juice extract (100 mg/kg, p.o. and 300 mg/kg, p.o.) and butanolic fraction of Punica granatum seed juice extract (100 mg/kg., p.o.) on cardiac parameters were studied. Isoproterenol hydrochloride was used to induce myocardial infarction in Wistar rats. At the end of the experiment, heart rate, ECG, pressure rate index and cardiac marker enzyme levels were assessed.Results:Rats treated with isoproterenol (85 mg/kg, administered subcutaneously twice at an interval of 24 h) showed a significant increase in heart rate, ST elevation in ECG, pressure rate index and a significant increase in the levels of cardiac marker enzymes- lactate dehydrogenase, and creatine kinase in serum. Isoproterenol significantly reduced superoxide dismutase and catalase activity and increased vascular reactivity to various catecholamines. Pretreatment with PJ (100 mg/kg, p.o. and 300 mg/kg, p.o.) and B-PJ (100 mg/kg., p.o.) for a period of 21 days significantly inhibited the effects of ISO on heart rate, PRI, ECG patterns, levels of LDH, CK, SOD, CAT, and vascular reactivity changes. Treatment with PJ (100 mg/kg and 300 mg/kg) and B-PJ (100 mg/kg., p.o.) alone did not alter any of the parameters as compared to vehicle-treated Wistar rats. Punica granatum-treated animals showed a lesser degree of cellular infiltration in histopathological studies.Conclusion:Punica granatum ameliorates cardiotoxic effects of isoproterenol and may be of value in the treatment of MI.

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Synergistic effect of nicorandil and amlodipine on mitochondrial function during isoproterenol-induced myocardial infarction in rats

Cited by 36 publications

References 31 publications

Protective effect of Centella asiatica on antioxidant tissue defense system against adriamycin induced cardiomyopathy in rats

Protective effect of Centella asiatica on antioxidant tissue defense system against adriamycin induced cardiomyopathy in rats

Protective effect of morin on cardiac mitochondrial function during isoproterenol-induced myocardial infarction in male Wistar rats

Cardioprotective potential of Punica granatum extract in isoproterenol-induced myocardial infarction in Wistar rats

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