Synergistic effect of fabrication and stabilization methods on physicochemical and biological properties of chitosan scaffolds

Gültan, Tuğçe; Tercan, Şeyma Bektaş; Altındal, Damla Çetin; Gümüşderelı́oğlu, Menemşe

doi:10.1080/00914037.2020.1725752

Cited by 7 publications

(16 citation statements)

References 27 publications

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“…14,34,70 For chitosan hydrogels or aerogels, the method with BGP [43][44][45][46][51][52][53] is most popular, but vanillin, 11,33 genipin, 29 L-aspartic acid 16,31 and TPP 11,68 can also be used. Chitosan membranes can be crosslinked with sodium alginate 41 or vanillin, 36 but genipin, 24 sodium carbonate 38,39 and ethanol 39 have been used to produce chitosan films. Porous chitosan scaffolds can be obtained using the largest number of crosslinking/stabilization methods listed: genipin, [20][21][22]27 L-aspartic acid, 15,30 vanillin, 11 sodium carbonate, 39,40 sodium alginate, 42 ethanol, 39,42,[54][55][56][57] thermal dehydration 58,62 and TPP.…”

Section: Crosslinking Of Chitosan and Stabilization Of Chitosan Struc...mentioning

confidence: 99%

“…Chitosan membranes can be crosslinked with sodium alginate 41 or vanillin, 36 but genipin, 24 sodium carbonate 38,39 and ethanol 39 have been used to produce chitosan films. Porous chitosan scaffolds can be obtained using the largest number of crosslinking/stabilization methods listed: genipin, [20][21][22]27 L-aspartic acid, 15,30 vanillin, 11 sodium carbonate, 39,40 sodium alginate, 42 ethanol, 39,42,[54][55][56][57] thermal dehydration 58,62 and TPP. 11,65,67 Crosslinking chitosan with cinnamaldehyde.…”

Section: Crosslinking Of Chitosan and Stabilization Of Chitosan Struc...mentioning

confidence: 99%

“…Depending on the amount of sodium carbonate, two reactions are possible: when the amount of carbonate used is small then two ammonium cations combine with the carbonate anion (Figure 7) or when the amount of carbonate is large then one ammonium cation and one sodium cation can combine with the carbonate anion which will limit the crosslinking. 38 Reserchers with crosslinking methods using sodium carbonate made films 38,39 and scaffolds. 39,40 Crosslinking chitosan with sodium alginate.…”

Section: Crosslinking Of Chitosan and Stabilization Of Chitosan Struc...mentioning

confidence: 99%

“…38 Reserchers with crosslinking methods using sodium carbonate made films 38,39 and scaffolds. 39,40 Crosslinking chitosan with sodium alginate. Sodium alginate (Alg) is a natural polymer composed of α-L-guluronic and β-Dmannuronic acid units linked by a β-1,4glycosidic bond.…”

Section: Crosslinking Of Chitosan and Stabilization Of Chitosan Struc...mentioning

confidence: 99%

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Methods for crosslinking and stabilization of chitosan structures for potential medical applications

Woźniak

Biernat

2022

Journal of Bioactive and Compatible Polymers

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Chitosan is a well-known polymer widely used in tissue engineering and regenerative medicine. It is biocompatible, biodegradable, non-toxic, has antibacterial and osteoconductive properties. Chitosan is often used in the form of composites (with the participation of ceramic particles), membranes, hydrogels or nanoparticles. The problem with biomaterials is their low durability, rapid degradation, poor mechanical properties and cytotoxicity. Cross-linking or stabilization of such materials allows for solving these problems. It is important that the compounds used for this purpose exhibit limited or no toxicity. The presented article is a review and presents some methods of cross-linking/stabilization of chitosan structures. The analysis concerns low or non-cytotoxic cross-linking/stabilization methods. The discussed compounds used for the purpose of chitosan structure fixation are: cinnamaldehyde, genipin, L-aspartic acid, vanillin, sodium carbonate, sodium alginate, BGP, ethanol and TPP. There is discussed also a hydrothermal/dehydrothermal method which seems to be promising as it is more advantageous since no additional compounds are introduced into the structure.

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Section: Crosslinking Of Chitosan and Stabilization Of Chitosan Struc...mentioning

confidence: 99%

Section: Crosslinking Of Chitosan and Stabilization Of Chitosan Struc...mentioning

confidence: 99%

Section: Crosslinking Of Chitosan and Stabilization Of Chitosan Struc...mentioning

confidence: 99%

Section: Crosslinking Of Chitosan and Stabilization Of Chitosan Struc...mentioning

confidence: 99%

See 2 more Smart Citations

Methods for crosslinking and stabilization of chitosan structures for potential medical applications

Woźniak

Biernat

2022

Journal of Bioactive and Compatible Polymers

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“…A porous chitosan scaffold was also obtained using ionic liquids, leading to swelling of water-insoluble chitosan to finally obtain a sponge-like, porous structure for cell encapsulation. The material displayed good biocompatibility towards human fibroblasts and human adipose stem cells [ 116 ]. Other natural polyaminoglycans, like gelatin [ 117 ], alginate [ 118 ] or a combination thereof [ 119 ], are used in the design of novel materials for bone grafts, such as the one designed by Lohmann et al [ 120 ].…”

Section: Bone Graft Substitutes For the Reconstruction Of Large Bomentioning

confidence: 99%

Challenges in Bone Tissue Regeneration: Stem Cell Therapy, Biofunctionality and Antimicrobial Properties of Novel Materials and Its Evolution

Riester

Borgolte

Csuk

et al. 2020

IJMS

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An aging population leads to increasing demand for sustained quality of life with the aid of novel implants. Patients expect fast healing and few complications after surgery. Increased biofunctionality and antimicrobial behavior of implants, in combination with supportive stem cell therapy, can meet these expectations. Recent research in the field of bone implants and the implementation of autologous mesenchymal stem cells in the treatment of bone defects is outlined and evaluated in this review. The article highlights several advantages, limitations and advances for metal-, ceramic- and polymer-based implants and discusses the future need for high-throughput screening systems used in the evaluation of novel developed materials and stem cell therapies. Automated cell culture systems, microarray assays or microfluidic devices are required to efficiently analyze the increasing number of new materials and stem cell-assisted therapies. Approaches described in the literature to improve biocompatibility, biofunctionality and stem cell differentiation efficiencies of implants range from the design of drug-laden nanoparticles to chemical modification and the selection of materials that mimic the natural tissue. Combining suitable implants with mesenchymal stem cell treatment promises to shorten healing time and increase treatment success. Most research studies focus on creating antibacterial materials or modifying implants with antibacterial coatings in order to address the increasing number of complications after surgeries that are mostly caused by bacterial infections. Moreover, treatment of multiresistant pathogens will pose even bigger challenges in hospitals in the future, according to the World Health Organization (WHO). These antibacterial materials will help to reduce infections after surgery and the number of antibiotic treatments that contribute to the emergence of new multiresistant pathogens, whilst the antibacterial implants will help reduce the amount of antibiotics used in clinical treatment.

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Synthesis-Structure Relationship of Chitosan Based Hydrogels

Ashok

Pradeep

Jayakumar

2021

Chitosan for Biomaterials III

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Synergistic effect of fabrication and stabilization methods on physicochemical and biological properties of chitosan scaffolds

Cited by 7 publications

References 27 publications

Methods for crosslinking and stabilization of chitosan structures for potential medical applications

Methods for crosslinking and stabilization of chitosan structures for potential medical applications

Challenges in Bone Tissue Regeneration: Stem Cell Therapy, Biofunctionality and Antimicrobial Properties of Novel Materials and Its Evolution

Synthesis-Structure Relationship of Chitosan Based Hydrogels

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