Synergistic effect of diethylstilbestrol on the mutagenicity of 2-acetylaminofluorene and N-hydroxy-acetylaminofluorene in the Salmonella assay system

Allaben, William T.; Louie, Shirley C.; Lazear, Edward J.

doi:10.1016/s0304-3835(79)80104-4

Cited by 7 publications

(1 citation statement)

References 8 publications

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“…Low doses of certain mutagenic agents appear to induce a response that facilitates repair of DNA damage. Agents that induce error-prone repair systems may facilitate carcinogenesis, while other environmental chemicals could inhibit repair processes, thereby preventing restorative processes [Sharma and Smith, 1986;Collins et al, 1984;Dunn and Regan, 19791. Numerous authors have reported comutagenic effects in which the mutagenicity of specific compounds has been enhanced by other agents [Hannan et al, 1981;Nagao et al, 1977a,b,c;Guttenplan, 1979;Allaben et al, 1979;Rao et al, 19791. While the precise mechanism of this enhancement is not yet obvious, the possibility that certain agents may facilitate the genetic activity of others in mixtures deserves further investigation.…”

Section: Effects On the Vulnerability Of The Hostmentioning

confidence: 99%

Biologic interactions between smoking and occupational exposures

Burns

Froines

Jarvik

1988

American J Industrial Med

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Cigarette smoking is a major cause of cancer and lung disease in the U.S. population. The biological processes that underlie the response of the lung to cigarette smoke are important considerations for designing analyses of the effects of occupational exposures. Interactions between cigarette smoking and occupational exposures may occur through a combined effect on the mechanism of disease production, through an effect on the dose of the toxic substances that reach the target issue, or through an effect on the response of the lung to the toxic agents. Disease due to occupational exposures can occur in a similar pattern in both smokers and nonsmokers; however, as more complex interactions are examined, different responses to the same occupational exposure may be identified for smokers and nonsmokers. It is only through the successful intermingling of biologic information with epidemiologic data that these interactions can be fully examined.

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Section: Effects On the Vulnerability Of The Hostmentioning

confidence: 99%

Biologic interactions between smoking and occupational exposures

Burns

Froines

Jarvik

1988

American J Industrial Med

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Synergistic, additive, and antagonistic mutagenic responses to binary mixtures of benzo(a)pyrene and benzo(e)pyrene as detected by strains TA98 and TA100 in the salmonella/microsome assay

et al. 1981

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Binary mixtures of benzo(a)pyrene (B(a)P) and benzo(e)pyrene (B(e)P) produce synergistic mutagenic (comutagenic) responses in Salmonella typhimurium strain TA98 (a frameshift detector). The optimum enhancement (25 X) was found at B(a)P concentration of 0.3 microgram/plate and B(e)P concentration of 1.5 microgram/plate. The response of strain TA100 (mostly a base-substitution detector) is opposite that of TA98, showing antagonism and additivity in similar concentration ranges.

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