Synergistic association of elevated serum free fatty acid and glucose levels with large arterial stiffness in a general population: The Nagahama Study

Tabara, Yasuharu; Takahashi, Yoshimitsu; Setoh, Kazuya; Kawaguchi, Takahisa; Gotoh, Noriko; Terao, Chikashi; Yamada, Ryo; Kosugi, Shinji; Sekine, Akihiro; Nakayama, Takeo; Matsuda, Fumihiko

doi:10.1016/j.metabol.2015.10.011

Cited by 7 publications

(4 citation statements)

References 24 publications

(33 reference statements)

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“…48,49 Elevated fasting FFAs are associated with brachial arterial stiffness measured by pulse wave velocity and with an increased risk incident of cardiac failure. 50,51 FFAs during hyperinsulinemia also correlated well with coronary artery calcification in adults with type 1 diabetes. 52 Chronic daytime elevations of FFAs in girls with PCOS could lead to increased vascular-specific inflammatory markers and the development of arterial stiffening and thickening of the intimal and medial layers of the arterial wall.…”

Section: Discussionmentioning

confidence: 75%

Obese adolescents with polycystic ovarian syndrome have elevated cardiovascular disease risk markers

et al. 2017

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Women with polycystic ovarian syndrome (PCOS) have evidence of subclinical cardiovascular disease (CVD). However, insulin resistance, an important factor in the development of CVD in adults, is common in adolescents with PCOS, yet data in adolescents are limited. Therefore, we sought to measure insulin resistance and CVD markers in obese youth with and without PCOS. Thirty-six PCOS and 17 non-PCOS adolescent girls who were obese, sedentary, and non-hypertensive were recruited from clinics located within the Children's Hospital Colorado. Following 3 days of controlled diet and restricted exercise, fasting plasma samples were obtained prior to a hyperinsulinemic euglycemic clamp. PCOS girls were more insulin resistant than controls (glucose infusion rate 5.24±1.86 mg/kg/min vs 9.10±2.69; p<0.001). Girls with PCOS had blood pressure in the normal range, but had greater carotid intima–media thickness (cIMT) (0.49±0.07 mm vs 0.44±0.06; p=0.038), beta stiffness index (5.1±1.3 U vs 4.4±0.9; p=0.037), and reduced arterial compliance (1.95±0.47 mm2/mmHg × 10−1 vs 2.13±0.43; p=0.047). PCOS girls had a normal mean lipid profile, yet had a more atherogenic lipoprotein cholesterol distribution and had persistent elevations of free fatty acids despite hyperinsulinemia (68±28 μmol/mL vs 41±10; p=0.001), both potential contributors to CVD. Free fatty acid concentrations correlated best with all CVD markers. In summary, adolescent girls with PCOS have greater cIMT and stiffer arteries than girls without PCOS, perhaps related to altered lipid metabolism, even when clinical measures of blood pressure and cholesterol profiles are ‘normal’. Therefore, management of adolescent PCOS should include assessment of CVD risk factor development.

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Section: Discussionmentioning

confidence: 75%

Obese adolescents with polycystic ovarian syndrome have elevated cardiovascular disease risk markers

et al. 2017

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“…In this cross-sectional study of 9396 Japanese subjects, Tabara et al [56] showed an association between elevated serum free fatty acids levels and large arterial stiffness, measured through brachial-to-ankle pulse wave velocity (baPWV) in a large-scale epidemiological setting. Individuals were subdivided according to clinical characteristics and fasting status.…”

Section: Non-interventional Clinical Research Studiesmentioning

confidence: 99%

Research advances in metabolism 2016

et al. 2017

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“…Many studies reported that arterial stiffness increases with age, 9 hypertension, 10 obesity, 11,12 smoking, 13 diastolic heart failure, 14 diabetes, 15 coronary artery disease, 16 peripheral arterial disease, 17 dyslipidemia, 18 and end-stage renal disease. 19 …”

Section: Introductionmentioning

confidence: 99%

“…[2][3][4] Other predictors include central pulse pressure (CPP) and augmentation index (AI), usually found elevated in patients with end-stage renal disease, and constitute strong independent predictors of all-cause mortality including cardiovascular mortality. [5][6][7][8] Many studies reported that arterial stiffness increases with age, 9 hypertension, 10 obesity, 11,12 smoking, 13 diastolic heart failure, 14 diabetes, 15 coronary artery disease, 16 peripheral arterial disease, 17 dyslipidemia, 18 and end-stage renal disease. 19 While many studies explored the relation of age to PWV and various sphygmocardiographic parameters, few have focused on the relations between the PWV and biochemical parameters.…”

Section: Introductionmentioning

confidence: 99%

Markers of arterial stiffness in a sample of Lebanese subjects with Grade I essential hypertension

Mallat

Assi²,

Jurjus

et al. 2017

SAGE Open Medicine

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Objectives:Arterial stiffness is becoming a major global condition associated with an increased risk of cardiovascular problems and death. Several markers have been linked to arterial stiffness.Methods:To determine and evaluate these relations, anthropometric parameters (weight, height, and pulse rate), biochemical profile, and central and peripheral indices of arterial function were measured in 114 Lebanese subjects with Grade I essential hypertension.Results:Age was associated with a higher pulse wave velocity (p = .001), central systolic blood pressure (p = .013), central pulse pressure (p = .028), central augmentation index (p ≤ .0001) with a lower heart rate (p = .08), and glomerular filtration rate (p = .019). Pulse wave velocity was found to be higher in older subjects (>65 years) and correlated with higher body mass index (r = .85) independent of age. Aging also correlated with higher plasma glucose and alterations in calcium–phosphorus metabolism.Conclusion:Aging is associated with increased arterial stiffness which is reflected by an increase in the pulse wave velocity, augmentation index, central pulse pressure, and central systolic blood pressure with a reduction in heart rate. Also, a higher body mass index and a lower estimated glomerular filtration rate (< 60 mL/min/1.73 m2) are associated with increased arterial stiffness while calcium and phosphorus metabolism may play a role by promoting vascular calcification.

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Synergistic association of elevated serum free fatty acid and glucose levels with large arterial stiffness in a general population: The Nagahama Study

Abstract: Physiological variations in FFA concentrations might be a risk factor for large arterial stiffness. FFA and hyperglycemia exert a synergistic adverse effect on the vasculature.

Cited by 7 publications

References 24 publications

Obese adolescents with polycystic ovarian syndrome have elevated cardiovascular disease risk markers

Obese adolescents with polycystic ovarian syndrome have elevated cardiovascular disease risk markers

Research advances in metabolism 2016

Markers of arterial stiffness in a sample of Lebanese subjects with Grade I essential hypertension

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