Markers of arterial stiffness in a sample of Lebanese subjects with Grade I essential hypertension

Mallat, Samir; Assi, Tarek; Jurjus, A; Shams, Ali; Sayegh, Skye El; Berbari, Adel E.

doi:10.1177/2050312117712886

Cited by 5 publications

(9 citation statements)

References 29 publications

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“…Obesity, which has reached an epidemic level owing to economic development in China, often coexists with MetS [9]. While the correlation between obesity and baPWV has not exhibited consistent results [10,11]. Currently, a subset of obese individuals without MetS, identi ed as metabolically healthy obese (MHO), attracted extensive attention due to the inconsistency on cardiovascular risk.…”

Section: Introductionmentioning

confidence: 99%

Risk of arterial stiffness according to metabolically healthy obese phenotype: a combined cross-sectional and longitudinal study in kailuan cohort

Wang

Zuo

et al. 2021

Aging

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BackgroundTo investigate the risk of incident arterial stiffness according to metabolically healthy obese (MHO) phenotype in Chinese population. Materials and methodsThe Kailuan study is an ongoing prospective cohort study, 37,180 participants with at least one-time measurement of branchial-ankle pulse wave velocity (baPWV) were included in the cross-sectional analysis, and 16,236 participants with repeated measurement of baPWV during the follow-ups were included in the longitudinal study from March 1, 2010, to January 31, 2020. Cross-classi cation of body mass index (BMI) categories and metabolic health status created six groups. Linear and logistic regression analyses were used to assess the association between BMI-metabolic status phenotypes and baPWV in mono-factor and multi-factor models. ResultsThe results of cross-sectional and longitudinal investigation were basically the same, as the abnormality of baPWV increased with BMI categories in metabolically healthy participants, while the increasing tendency disappeared in metabolically unhealthy participants. A 1.6-fold, 2.8-fold increased risk for the new occurrence of arterial stiffness were documented in MHO and metabolically unhealthy obese participants compared to metabolically healthy normal weight controls in the fully adjusted model. Further strati ed analysis shown that metabolic health status was an interaction factor between BMI and arterial stiffness in either study population (P<0.0001 for cross-sectional study and P=0.0003 for longitudinal study). ConclusionsMetabolic health status and BMI categories contribute to the progression of arterial stiffness, while BMI is positively associated with arterial stiffness only in metabolically healthy participants. Moreover, MHO is an intermediate stage between metabolically healthy and unhealthy status.

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Section: Introductionmentioning

confidence: 99%

Risk of arterial stiffness according to metabolically healthy obese phenotype: a combined cross-sectional and longitudinal study in kailuan cohort

Wang

Zuo

et al. 2021

Aging

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“…BMI is one of the main measures for general obesity, and is commonly used in clinical assessment and screenings. However, researches on the association between BMI and baPWV among hypertensive patients have not shown consistent results; studies have reported an insignificant relationship [9], positive relationship [10], or negative relationship [11,12]. Possible reasons for these conflicts might be study limitations of small sample size or different origins of the study population.…”

Section: Introductionmentioning

confidence: 99%

Association Between Body Mass Index (BMI) and Brachial-Ankle Pulse Wave Velocity (baPWV) in Males with Hypertension: A Community-Based Cross-Section Study in North China

et al. 2019

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Background The aim of this study was to investigate the association between body mass index (BMI) and brachial-ankle pulse wave velocity (baPWV) in hypertensive males. Material/Methods Altogether, 14 866 male hypertensive participants were included in the analysis. Participants were divided into 3 groups: low BMI group (BMI <24 kg/m 2 ), moderate BMI group (24 kg/m 2 ≤BMI <28 kg/m 2 ), and high BMI group (BMI ≥28 kg/m 2 ). According to baPWV values, arteriosclerosis (AS) was set as 3 degrees: mild AS (baPWV ≥1400 cm/s), moderate AS (baPWV ≥1700 cm/s) and severe AS (baPWV ≥2000 cm/s). Multivariate logistic regression analysis was used to explore the effect of different BMI groups on different degrees of AS. The multivariate linear regression analysis was used to explore the relationship between BMI and baPWV. Results Among low BMI, moderate BMI, and high BMI groups, the average baPWV values were 1824±401 cm/s, 1758±363 cm/s, and 1686±341 cm/s, respectively. Prevalence in the mild, moderate and high BMI groups were 91.0%, 87.8%, 81.5%, respectively for mild AS; 55.3%, 48.8%, and 40.0% respectively for moderate AS; and 25.9%, 20.2%, and 14.9% respectively for severe AS. Compared to the low BMI group, multivariate logistic regression analysis showed that odds ratio (OR) and 95% confidence intervals (95%CI) in the moderate BMI group and the high BMI were 0.71 (95%Cl, 0.62–0.80), 0.43 (95%Cl, 0.38–0.50) for mild AS; and similar trends were shown for moderate AS and severe AS. Based on age-stratification, a negative relationship remained for 35–55 years old participants for different degrees of AS among the moderate BMI group and the high BMI group. A negative relationship was detected between BMI and baPWV in total and different age-stages. Conclusions Among male hypertension participants in this study, there was a negative relationship between BMI and baPWV. High BMI was found to be a protective factor for AS especially in the age range of 35–55 years.

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“…Similarly, Huang et al [29] and Liu et al [18] found that there was a negative relationship between BMI and baPWV among male hypertension participants. On the contrary, previous studies showed that a higher BMI was associated with increased PWV in Grade I essential hypertension [15] or obese and non-obese hypertensive patients [17]. Different origins of the study participants might contribute to the study differences.…”

Section: Discussionmentioning

confidence: 81%

“…The Liu et al [18] study was based on 699 male hypertensive patients who were hospitalization or had other complications. The Samir et al [15] study was based on 114 patients with Grade I essential hypertension who were civil servants. The Huang et al [29] study enrolled 10 1510 participants, a coal occupation group in labor-intensive enterprise, from 11 hospitals in the Kailuan community, which is most similar to our rural hypertensive crowd.…”

Section: Discussionmentioning

confidence: 99%

“…Body mass index (BMI) is one of the main measures for general obesity, and is commonly used in clinical assessment and screenings. However, researches on the association between BMI and PWV in various population including the hypertensive patients [14][15][16][17][18] which often accompanied with overweight or obesity [19], remian controversial: studies have reported an insigni cant relationship [14,18,[20][21][22][23][24], positive relationship [15,17,[25][26][27][28], or negative relationship [16,29,[30][31][32][33]. Many causes could interpret these apparent discrepancies including diverse sample size, different origins of the study population, ethnic and regional disparity.…”

Section: Introductionmentioning

confidence: 99%

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Body Mass Index or Waist-Hip Ratio, Which Correlated With Arterial Stiffness Based on Brachial-Ankle Pulse Wave Velocity in Chinese Rural Adults With Hypertension?

Han

et al. 2021

Preprint

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Background: The aim of this study was to investigate the association betweenbody mass index (BMI), waist-hip ratio (WHR) and arterial stiffness (AS) based on brachial-ankle pulse wave velocity (baPWV) in Chinese rural adults with hypertension.Methods: In this analysis, selected 5,049 Chinese rural adults with hypertension were divided into three groups according to BMI ( <24 kg/m2, control; 24‐28 kg/m2, overweight; and ≥28 kg/m2, obesity), WHR ≥0.9 for male and ≥0.85 for female was defined as central obesity, while baPWV ≥18.0 m/s was considered as increased AS. Multivariate analysis was used to examine the association between BMI, WHR (central obesity) and AS based on baPWV in different models. Furthermore, the generalized additive model and smooth curve fitting was used to visually show the relationship between BMI or WHR with baPWV. Finally, to ensure the robustness between BMI group or central obesity with increased AS, we also did the subgroup analyses that were performed using stratified multivariate regression and interaction analyses and presented in tabulated form or forest plot.Results: The prevalence of overweight, general obesity, central obesity and increased AS were 32.62%, 8.58%, 63.85% and 44.01%, respectively. In comparsion with control group, there are a statistically significant lower prevalence of increased AS in population with overweight or general obesity (adjusted-OR: 0.78, 95% CI 0.65 to 0.92, P <0.001; adjusted-OR: 0.54, 95% CI 0.40 to 0.72, P <0.001, respectively; P for trend <0.001). Whereby in comparsion with non-central obesity group, there are an statistically significant higher prevalence of increased AS in population with central obesity (adjusted-OR: 1.54, 95% CI 1.30 to 1.83, P <0.001). The multivariate analyses indicated that BMI was negatively associated with baPWV (adjusted-β per SD increase: -0.49, 95% CI -0.60 to -0.38, P <0.001). In comparsion with control group, there are an statistically significant inversely relationship between BMI and baPWV in population with overweight or general obesity (adjusted-β: -0.55, 95% CI -0.75 to -0.35, P <0.001; adjusted-β: -1.00, 95% CI -1.32 to -0.67, P <0.001, respectively; P for trend <0.001). On the contrary, WHR was positively associated with baPWV (adjusted-β per SD increase: 0.27, 95% CI 0.17 to 0.38, P <0.001). In comparsion with non-central obesity group, there are a statistically significant positively relationship between WHR and baPWV in population with central obesity (adjusted-β: 0.55, 95% CI 0.34 to 0.75, P <0.001).Conclusion: We found that there was an inversely relationship between BMI and baPWV or increased AS, whereas WHR or central obesity is positively associated with baPWV and increased AS in Chinese rural adults with hypertension.

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Markers of arterial stiffness in a sample of Lebanese subjects with Grade I essential hypertension

Cited by 5 publications

References 29 publications

Risk of arterial stiffness according to metabolically healthy obese phenotype: a combined cross-sectional and longitudinal study in kailuan cohort

Risk of arterial stiffness according to metabolically healthy obese phenotype: a combined cross-sectional and longitudinal study in kailuan cohort

Association Between Body Mass Index (BMI) and Brachial-Ankle Pulse Wave Velocity (baPWV) in Males with Hypertension: A Community-Based Cross-Section Study in North China

Body Mass Index or Waist-Hip Ratio, Which Correlated With Arterial Stiffness Based on Brachial-Ankle Pulse Wave Velocity in Chinese Rural Adults With Hypertension?

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