Synergistic antimicrobial therapy using nanoparticles and antibiotics for the treatment of multidrug-resistant bacterial infection

Gupta, Akash; Saleh, N.; Das, Rahul; Landis, Ryan F.; Bigdeli, Arafeh; Motamedchaboki, Khatereh; Campos, Alexandre Rosa; Pomeroy, Kenneth; Mahmoudi, Morteza; Rotello, Vincent M.

doi:10.1088/2399-1984/aa69fb

Cited by 80 publications

(53 citation statements)

References 51 publications

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“…Furthermore, NPs can direct these to the bacterium–antibiotic interface for promoting efficient interaction 165. Combined administration of NPs with antibiotics as the treatment regimen can reduce the required amount of both antibiotics and NP, thereby reducing toxicity risks and synergistically enhancing the effects of their antimicrobial activities 166. In addition to tagged nanocarriers, stimuli‐responsive antibiotic releasing systems own the constituents to achieve stimuli‐triggered response and provide synergetic effects between the antibacterial content and exogenous stimuli.…”

Section: Nanomaterial‐integrated Diagnosis Prevention and Therapy Omentioning

confidence: 99%

Evolving Technologies and Strategies for Combating Antibacterial Resistance in the Advent of the Postantibiotic Era

Karaman

Ercan

Bakay

et al. 2020

Adv Funct Materials

110

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The threats posed by the impending "postantibiotic era" have put forward urgent challenges to be overcome by providing new diagnostic and therapeutic regimes for improved diagnosis and treatment of bacterial infections. Antibiotic resistance and incurable bacterial infections are especially important in a society faced with rapid demographic changes. With very few new antibiotics in the drug development pipeline, not being able to match the pace of antimicrobial resistance evolution, developments within other fields such as materials sciences and medical technologies are required to realize innovative antibacterial approaches. This progress report presents recent advances in especially nanotechnology-based approaches and their concomitant use with complementary antibacterial treatments. Synergistically improved antibacterial activity can be reached by considering novel, promising approaches such as photodynamic and photothermal therapy as well as cold atmospheric pressure treatments as complementary strategies to fight against antibacterial resistance. Moreover, this report describes how these novel technologies can be further improved especially by integration of nanomaterials into the currently applied single modal strategies against bacterial infections.

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Section: Nanomaterial‐integrated Diagnosis Prevention and Therapy Omentioning

confidence: 99%

Evolving Technologies and Strategies for Combating Antibacterial Resistance in the Advent of the Postantibiotic Era

Karaman

Ercan

Bakay

et al. 2020

Adv Funct Materials

110

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“…Lately by using biogenic synthesis method, Sangaonkar and Pawar (2018) conjugated small sized Ag-nanoparticles (5-30 nm) with tetracycline, and this compound displayed biocidal action against four of the seven bacteria tested [32]. The mechanism of action involved deregulation of main efflux pump (tolC) and downregulation of proteins responsible for assembling of (tolC) in E. coli outer membrane [33].…”

Section: Antibiotics Capped Nanoparticlesmentioning

confidence: 99%

The Use of Nanomedicine for Targeted Therapy against Bacterial Infections

et al. 2019

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The emergence of drug resistance combined with limited success in the discovery of newer and effective antimicrobial chemotherapeutics poses a significant challenge to human and animal health. Nanoparticles may be an approach for effective drug development and delivery against infections caused by multi-drug resistant bacteria. Here we discuss nanoparticles therapeutics and nano-drug delivery against bacterial infections. The therapeutic efficacy of numerous kinds of nanoparticles including nanoantibiotics conjugates, small molecules capped nanoparticles, polymers stabilized nanoparticles, and biomolecules functionalized nanoparticles has been discussed. Moreover, nanoparticles-based drug delivery systems against bacterial infections have been described. Furthermore, the fundamental limitation of biocompatibility and biosafety of nanoparticles is also conferred. Finally, we propose potential future strategies of nanomaterials as antibacterials.physical strength, electrical conductance, chemical reactivity and optical effects [11]. These criteria help in increasing the surface area, enhancing release of drug, reducing the dose required, and improving solubility and bioavailability of the compounds [12]. Moreover, these properties are also important for the diagnosis of microbial diseases with high sensitivity and selectivity and those with fluorescent properties or labeled with fluorescent dyes have also been employed for bacterial detection and susceptibility. In addition, inorganic nanoparticle-based diagnostic approaches depend upon the identification of known bacterial genome sequences by directing probes, and thus may not recognize altered and/or novel bacterial strains [13]. Furthermore, nanoparticles based specific drug targeting improve the therapeutic index, increase stability of drug, and decrease drug resistance. For example, silver nanoparticles affect Escherichia coli by forming complex with electron donor groups on amino acids and nucleic acids [12]. At present, liposomal drugs and polymer-drug conjugates have been approved for infectious diseases treatment, and many other antimicrobial nanoparticle formulations are under preclinical test [14].Gold nanoparticles have gained significant attention recently due to their tunable antimicrobial applications. Gold has been the subject of interest against bacterial infections for its biocompatibility and ease in conjugation with drugs and biomolecules. Gold conjugated with various drugs have shown to enhance their efficacy against bacteria. Gold nanoparticles coated with aminoglycosides have been found to be efficient antibacterial agents against various bacteria such as Staphylococcus aureus, Micrococcus luteus, E. coli and Pseudomonas aeruginosa [15]. In another study, after assessment of the surface chemistry of nanoparticles, the synergistic mechanism showed that hydrophobic cationic conjugated gold nanoparticles reduced the minimum inhibitory concentration (MIC) of fluoroquinolone against multidrug resistant by 8-16 times [16]. More recently, formulatio...

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“…Several classes of antimicrobial NPs and nano-sized carriers for antibiotic delivery have proven effective in treating infectious diseases, including antibiotic-resistant ones, in vitro as well as in animal models [117]. Very recently, we demonstrated that even multidrug-resistant bacterial infection can be treated by synergistic antimicrobial therapy using NPs and antibiotics [119]. NPs with different physicochemical properties use different pathways to attack the bacterial infection.…”

Section: Antibacterial Nanotechnologies To Combat Orthopedic Infecmentioning

confidence: 99%

“…5) [121,122]. We have thoroughly reviewed the antibacterial properties of a wide range of NPs [119]; readers are referred to that review for details on specific types of NPs and their corresponding mechanisms of action. Here, we will focus solely on NP platforms designed to impede the bacterial activity associated with orthopedic trauma surgery.…”

Section: Antibacterial Nanotechnologies To Combat Orthopedic Infecmentioning

confidence: 99%

Nanomedicine for safe healing of bone trauma: Opportunities and challenges

et al. 2017

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Historically, high-energy extremity injuries resulting in significant soft-tissue trauma and bone loss were often deemed unsalvageable and treated with primary amputation. With improved soft-tissue coverage and nerve repair techniques, these injuries now present new challenges in limb-salvage surgery. High-energy extremity trauma is pre-disposed to delayed or unpredictable bony healing and high rates of infection, depending on the integrity of the soft-tissue envelope. Furthermore, orthopedic trauma surgeons are often faced with the challenge of stabilizing and repairing large bony defects while promoting an optimal environment to prevent infection and aid bony healing. During the last decade, nanomedicine has demonstrated substantial potential in addressing the two major issues intrinsic to orthopedic traumas (i.e., high infection risk and low bony reconstruction) through combatting bacterial infection and accelerating/increasing the effectiveness of the bone-healing process. This review presents an overview and discusses recent challenges and opportunities to address major orthopedic trauma through nanomedical approaches.

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Synergistic antimicrobial therapy using nanoparticles and antibiotics for the treatment of multidrug-resistant bacterial infection

Cited by 80 publications

References 51 publications

Evolving Technologies and Strategies for Combating Antibacterial Resistance in the Advent of the Postantibiotic Era

Evolving Technologies and Strategies for Combating Antibacterial Resistance in the Advent of the Postantibiotic Era

The Use of Nanomedicine for Targeted Therapy against Bacterial Infections

Nanomedicine for safe healing of bone trauma: Opportunities and challenges

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