Synergistic Antifungal Effect of a Combination of Iron Deficiency and Calcium Supplementation

Ye, Jing; Wang, Yamei; Li, Xinyu; Wan, Qinyi; Zhang, Yuanwei; Lü, Ling

doi:10.1128/spectrum.01121-22

Cited by 9 publications

(7 citation statements)

References 78 publications

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“…Even though mucormycosis was present only among 1.5% of the population studied, this was a major post-COVID-19 infection case. Previous research has reported that iron deficiency causes calcium overload and increased intracellular accumulation of reactive oxygen species (ROS), thereby leading to disturbed ion homeostasis and finally suppressing fungal growth [ 24 ]. However, aplastic anemia patients were proven to have an increased prevalence of fungal infections [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Clinico-Demographic Parameters of Oral Fungal Infections: An Institutional Retrospective Study

Devi,

Kizhakkoottu

2024

Cureus

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Introduction Most fungal infections are responsive to antifungal therapy. However, failure to diagnose the same can significantly affect the quality of lives of patients. Timely identification of fungal infections and their association with varied demographic and clinical parameters will help in improving the prognosis of the patient. The present study aims to evaluate the prevalence of fungal infections among various age groups and genders and also to evaluate the association of fungal infections with demographic parameters. Methods This study included a sample size of n = 600. The demographic and clinical details were compiled and transferred to IBM SPSS Version 23 software (IBM Corp., Armonk, NY) for statistical analysis. Descriptive and Pearson chi-square tests were used to analyze the association of the type of fungal infection with gender, age, and comorbidities. A p-value of less than 0.05 is considered statistically significant. Results Angular cheilitis (40%, 240), followed by denture stomatitis (37.5%, 225), were the most common type of fungal infection among the sample population, and the elderly age group (51-72 years) was the most affected. Angular cheilitis was the most common infection among both males (21.4%, 128) and females (18.6%, 112), but candidiasis was reported more in females (18%, 108) than males (3%, 18) (p = 0.00). Angular cheilitis (32%, 192) and candidiasis (18%, 108) were more observed in association with anemia; however, denture stomatitis (34%, 204) was significantly higher among diabetics (p = 0.00). Conclusion The identification of associated systemic and demographic factors is as important as the treatment of fungal infection itself. The recognition of fungal infections and the role of parameters like age, gender, and systemic comorbidities in the development of fungal infections will have valuable implications for public health. Future research is required for a clear understanding of the same.

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Section: Discussionmentioning

confidence: 99%

Clinico-Demographic Parameters of Oral Fungal Infections: An Institutional Retrospective Study

Devi,

Kizhakkoottu

2024

Cureus

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“…The advanced resazurin test as the previous report was used to evaluate the metabolic activity of HHP-treated spores ( 37 ). Firstly, A. sydowii spores were scratched from PDA by employing a minimal medium containing 1% (wt/vol) glucose, 0.5/2.0 M NaCl, and 70 mM NaNO 3 ; then, spore suspension (1 × 10 5 cells/mL) was inoculated under 0.1 MPa, 20 MPa, and 40 MPa at 28°C, respectively.…”

Section: Methodsmentioning

confidence: 99%

Insight into the adaptation mechanisms of high hydrostatic pressure in physiology and metabolism of hadal fungi from the deepest ocean sediment

Zhong,

Li,

Deng

et al. 2024

mSystems

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High hydrostatic pressure (HHP) influences the life processes of organisms living at depth in the oceans. While filamentous fungi are one of the essential members of deep-sea microorganisms, few works have explored their piezotolerance to HHP. Here, we obtained three homogeneous Aspergillus sydowii from terrestrial, shallow, and hadal areas, respectively, to compare their pressure resistance. A set of all-around evaluation methods including determination of growth rate, metabolic activity, and microscopic staining observation was established and indicated that A. sydowii DM1 from the hadal area displayed significant piezotolerance. Global analysis of transcriptome data under elevated HHP revealed that A. sydowii DM1 proactively modulated cell membrane permeability, hyphae morphology, and septal quantities for seeking a better livelihood under mild pressure. Besides, differentially expressed genes were mainly enriched in the biosynthesis of amino acids, carbohydrate metabolism, cell process, etc., implying how the filamentous fungi respond to elevated pressure at the molecular level. We speculated that A. sydowii DM1 could acclimatize itself to HHP by adopting several strategies, including environmental response pathway HOG-MAPK, stress proteins, and cellular metabolisms. IMPORTANCE Fungi play an ecological and biological function in marine environments, while the physiology of filamentous fungi under high hydrostatic pressure (HHP) is an unknown territory due to current technologies. As filamentous fungi are found in various niches, Aspergillus sp. from deep-sea inspire us to the physiological trait of eukaryotes under HHP, which can be considered as a prospective research model. Here, the evaluation methods we constructed would be universal for most filamentous fungi to assess their pressure resistance, and we found that Aspergillus sydowii DM1 from the hadal area owned better piezotolerance and the active metabolisms under HHP indicated the existence of undiscovered metabolic strategies for hadal fungi. Since pressure-related research of marine fungi has been unexpectedly neglected, our study provided an enlightening strategy for them under HHP; we believed that understanding their adaptation and ecological function in original niches will be accelerated in the perceivable future.

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“…Calcium is a noncompetitive inhibitor of ferrous transporter 1 (DMT1) during intestinal iron absorption 24 . Calcium also induces the downregulation of genes related to iron absorption 25 . Another study also found that a low‐calcium diet increased tissue iron levels in ovariectomized rats 26 .…”

Section: Vitamin D and Ferroptosismentioning

confidence: 98%

Vitamin D may alleviate pre‐eclampsia by modulating the ferroptosis signalling pathway: A hypothesis based on recent literature

Su²,

2023

J Cellular Molecular Medi

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Ferroptosis is a novel form of regulated cell death typically characterized by non‐apoptotic, iron‐dependent, and reactive accumulation of oxygen species. Recent studies have found that ferroptosis plays an important role in the pathophysiology of pre‐eclampsia (PE). In order to find potential therapeutic targets for ferroptosis intervention and better prevent the occurrence and progression of PE, the signalling pathways that regulate ferroptosis need to be identified. In this article, we review the role of vitamin D in PE and the role of ferroptosis in PE. Based on recent literature, we propose the scientific hypothesis that vitamin D can alleviate preeclampsia by modulating the ferroptosis signalling pathway. The aim of this review is to understand the regulatory pathways of ferroptosis in PE and to identify potential therapeutic targets.

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Synergistic Antifungal Effect of a Combination of Iron Deficiency and Calcium Supplementation

Abstract: Millions of immunocompromised people are at a higher risk of developing different types of severe fungal diseases. The limited number of antifungals and the emergence of antimicrobial resistance highlight an urgent need for new strategies against invasive fungal infections.

Cited by 9 publications

References 78 publications

Clinico-Demographic Parameters of Oral Fungal Infections: An Institutional Retrospective Study

Clinico-Demographic Parameters of Oral Fungal Infections: An Institutional Retrospective Study

Insight into the adaptation mechanisms of high hydrostatic pressure in physiology and metabolism of hadal fungi from the deepest ocean sediment

Vitamin D may alleviate pre‐eclampsia by modulating the ferroptosis signalling pathway: A hypothesis based on recent literature

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