Synergistic Anticancer Effects Achieved by Co‐Delivery of TRAIL and Paclitaxel Using Cationic Polymeric Micelles

Lee, Ashlynn L. Z.; Wang, Yong; Pervaiz, Shazib; Fan, Weimin; Yang, Yi Yan

doi:10.1002/mabi.201000332

Cited by 50 publications

(22 citation statements)

References 29 publications

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“…The maximum tolerated dose of PGG-PTX was found to be 350 mg PTX/kg, which is 2.2-fold higher than the maximum tolerated dose of 160 mg PTX/kg reported for the PGA-PTX [88]. In a different study, cationic micellar nanoparticles self-assembled from a biodegradable amphiphilic copolymer were used to deliver human TRAIL (Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand) and Paclitaxel simultaneously [89]. Polyplexes formed between Paclitaxel-loaded nanoparticles and TRAIL were observed to be stable, with a size of about 180 nm and a zeta potential at about 75 mV.…”

Section: Taxolmentioning

confidence: 99%

Nanoparticle Delivery of Natural Products in the Prevention and Treatment of Cancers: Current Status and Future Prospects

Bharali

Siddiqui

Adhami

et al. 2011

Cancers

101

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The advent of nanotechnology has had a revolutionary impact on many aspects of 21st century life. Nanotechnology has provided an opportunity to explore new avenues that conventional technologies have been unable to make an impact on for diagnosis, prevention, and therapy of different diseases, and of cancer in particular. Entities in nanometer sizes are excellent platforms to incorporate various drugs or active materials that can be delivered effectively to the desired action site without compromising the activity of the incorporated drug or material. In particular, nanotechnology entities can be used to deliver conventional natural products that have poor solubility or a short half life. Conventional natural products used with entities in nanometer sizes enable us to solve many of the inherent problems (stability, solubility, toxicity) associated with natural products, and also provide a platform for targeted delivery to tumor sites. We recently introduced the novel concept of using nanotechnology for enhancing the outcome of chemoprevention, which we called ‘nanochemoprevention’. This idea was subsequently exploited by several laboratories worldwide and has now become an advancing field in chemoprevention research. This review examines some of the applications of nanotechnology for cancer prevention and therapy using natural products.

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Section: Taxolmentioning

confidence: 99%

Nanoparticle Delivery of Natural Products in the Prevention and Treatment of Cancers: Current Status and Future Prospects

Bharali

Siddiqui

Adhami

et al. 2011

Cancers

101

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“…Lee et al showed that micelles fabricated from an amphiphilic cholesterol-bearing copolymer, ie, poly[N-methyldietheneamine sebacate-co(cholesteryl oxocarbonylamido ethyl) methyl bis (ethylene) ammonium bromide sebacate], achieved a high paclitaxel loading of about 14% with an encapsulation efficiency of about 92% using a simple self-assembly process without homogenization or sonication. 21 Cabazitaxel (previously also known as taxoid, XRP6258, TXD258, or RPR 116258A) is a novel antineoplastic agent belonging to the taxane class. Due to its poor affinity for P-glycoprotein, cabazitaxel has demonstrated antitumor activity not only against docetaxel-sensitive tumor models but also against docetaxel-insensitive tumor models.…”

mentioning

confidence: 99%

Self-assembled micelles of novel amphiphilic copolymer cholesterol-coupled F68 containing cabazitaxel as a drug delivery system

Song¹,

Tian²,

Huang³

et al. 2014

IJN

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Despite being one of the most promising amphiphilic block copolymers, use of Pluronic F68 in drug delivery is limited due to its high critical micelle concentration (CMC). In this study, we developed a novel F68 derivative, cholesterol-coupled F68 (F68-CHMC). This new derivative has a CMC of 10 μg/mL, which is 400-fold lower than that of F68. The drug-loading capacity of F68-CHMC was investigated by encapsulating cabazitaxel, a novel antitumor drug. Drug-loaded micelles were fabricated by a self-assembly method with simple dilution. The optimum particle size of the micelles was 17.5±2.1 nm, with an entrapment efficiency of 98.1% and a drug loading efficiency of 3.16%. In vitro release studies demonstrated that cabazitaxel-loaded F68-CHMC micelles had delayed and sustained-release properties. A cytotoxicity assay of S180 cells showed that blank F68-CHMC was noncytotoxic with a cell viability of nearly 100%, even at a concentration of 1,000 μg/mL. The IC 50 revealed that cabazitaxel-loaded F68-CHMC micelles were more cytotoxic than Tween 80-based cabazitaxel solution and free cabazitaxel. In vivo antitumor activity against S180 cells also indicated better tumor inhibition by the micelles (79.2%) than by Tween 80 solution (56.2%, P <0.05). Based on these results, we conclude that the F68-CHMC copolymer may be a potential nanocarrier to improve the solubility and biological activity of cabazitaxel and other hydrophobic drugs.

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“…126 In a very recent study, cationic micellar nanoparticles self-assembled from a biodegradable amphiphilic copolymer were used to deliver human TRAIL and paclitaxel simultaneously. 127 Polyplexes formed between paclitaxel-loaded nanoparticles and TRAIL was observed to be stable, with a size of approximately 180 nm and a zeta potential at about 75 mV. Anticancer effects and apoptotic pathway mechanisms of this drug-and-protein codelivery system were investigated in various human breast cancer cell lines with different TRAIL sensitivity.…”

Section: Paclitaxelmentioning

confidence: 99%

Impact of nanotechnology in cancer: emphasis on nanochemoprevention

Mukhtar¹

2012

IJN

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Since its advent in the field of cancer, nanotechnology has provided researchers with expertise to explore new avenues for diagnosis, prevention, and treatment of the disease. Utilization of nanotechnology has enabled the development of devices in nanometer (nm) sizes which could be designed to encapsulate useful agents that have shown excellent results but otherwise are generally toxic due to the doses intended for extended use. In addition, examples are also available where these devices are easily conjugated with several purposeful moieties for better localization and targeted delivery. We introduced a novel concept in which nanotechnology was utilized for enhancing the outcome of chemoprevention. This idea, which we termed as "nanochemoprevention," was subsequently exploited by several laboratories worldwide and has now become an advancing field in chemoprevention research. This review examines some of the up and coming applications of nanotechnology for cancer detection, imaging, treatment, and prevention. Further, we detail the current and future utilization of nanochemoprevention for prevention and treatment of cancer.

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Synergistic Anticancer Effects Achieved by Co‐Delivery of TRAIL and Paclitaxel Using Cationic Polymeric Micelles

Cited by 50 publications

References 29 publications

Nanoparticle Delivery of Natural Products in the Prevention and Treatment of Cancers: Current Status and Future Prospects

Nanoparticle Delivery of Natural Products in the Prevention and Treatment of Cancers: Current Status and Future Prospects

Self-assembled micelles of novel amphiphilic copolymer cholesterol-coupled F68 containing cabazitaxel as a drug delivery system

Impact of nanotechnology in cancer: emphasis on nanochemoprevention

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