Impact of nanotechnology in cancer: emphasis on nanochemoprevention

Mukhtar, Hasan

doi:10.2147/ijn.s26026

Cited by 35 publications

(5 citation statements)

References 130 publications

(152 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some of the nanoformulations have been approved by the FDA are currently available in the market. A detailed list of approved formulations is available [33, 35]. Among these, the albumin-bound paclitaxel (PTX) poly(lactide- co -glycolide) (PLGA) nanoformulation (Abraxane ™ , http://www.abraxane.com/dtc/) is highly successful in increasing the specificity and treatment efficiency of various cancer(s).…”

Section: Curcumin Nanoformulationsmentioning

confidence: 99%

Curcumin Nanomedicine: A Road to Cancer Therapeutics

Yallapu¹,

Jaggi²,

Chauhan³

2013

Current Pharmaceutical Design

View full text Add to dashboard Cite

Cancer is the second leading cause of death in the United States. Conventional therapies cause widespread systemic toxicity and lead to serious side effects which prohibit their long term use. Additionally, in many circumstances tumor resistance and recurrence is commonly observed. Therefore, there is an urgent need to identify suitable anticancer therapies that are highly precise with minimal side effects. Curcumin is a natural polyphenol molecule derived from the Curcuma longa plant which exhibits anticancer, chemo-preventive, chemo- and radio-sensitization properties. Curcumin’s widespread availability, safety, low cost and multiple cancer fighting functions justify its development as a drug for cancer treatment. However, various basic and clinical studies elucidate curcumin’s limited efficacy due to its low solubility, high rate of metabolism, poor bioavailability and pharmacokinetics. A growing list of nanomedicine(s) using first line therapeutic drugs have been approved or are under consideration by the Food and Drug Administration (FDA) to improve human health. These nanotechnology strategies may help to overcome challenges and ease the translation of curcumin from bench to clinical application. Prominent research is reviewed which shows that advanced drug delivery of curcumin (curcumin nanoformulations or curcumin nanomedicine) is able to leverage therapeutic benefits by improving bioavailability and pharmacokinetics which in turn improves binding, internalization and targeting of tumor(s). Outcomes using these novel drug delivery systems have been discussed in detail. This review also describes the tumor-specific drug delivery system(s) that can be highly effective in destroying tumors. Such new approaches are expected to lead to clinical trials and to improve cancer therapeutics.

show abstract

Section: Curcumin Nanoformulationsmentioning

confidence: 99%

Curcumin Nanomedicine: A Road to Cancer Therapeutics

Yallapu¹,

Jaggi²,

Chauhan³

2013

Current Pharmaceutical Design

View full text Add to dashboard Cite

show abstract

“…Consequently, development of advanced treatment modalities is needed, especially to avoid the morbidity of toxic side effects during chemotherapy. Targeted drug delivery has been an important focus of recent research, especially for cancer chemotherapy ( 30 – 33 ). Numerous projects have focused on selective tumor delivery of highly toxic drugs that can be transported to cancer cells and tumors without damage to normal tissues ( 34 – 36 ).…”

Section: Introductionmentioning

confidence: 99%

Pre-Clinical Evaluation of rHDL Encapsulated Retinoids for the Treatment of Neuroblastoma

Sabnis¹,

Pratap²,

Akopova³

et al. 2013

Front. Pediatr.

View full text Add to dashboard Cite

Despite major advances in pediatric cancer research, there has been only modest progress in the survival of children with high risk neuroblastoma (NB) (HRNB). The long term survival rates of HRNB in the United States are still only 30–50%. Due to resistance that often develops during therapy, development of new effective strategies is essential to improve the survival and overcome the tendency of HRNB patients to relapse subsequent to initial treatment. Current chemotherapy regimens also have a serious limitation due to off target toxicity. In the present work, we evaluated the potential application of reconstituted high density lipoprotein (rHDL) containing fenretinide (FR) nanoparticles as a novel approach to current NB therapeutics. The characterization and stability studies of rHDL-FR nanoparticles showed small size (<40 nm) and high encapsulation efficiency. The cytotoxicity studies of free FR vs. rHDL/FR toward the NB cell lines SK-N-SH and SMS-KCNR showed 2.8- and 2-fold lower IC50 values for the rHDL encapsulated FR vs. free FR. More importantly, the IC50 value for retinal pigment epithelial cells (ARPE-19), a recipient of off target toxicity during FR therapy, was over 40 times higher for the rHDL/FR as compared to that of free FR. The overall improvement in in vitro selective therapeutic efficiency was thus about 100-fold upon encapsulation of the drug into the rHDL nanoparticles. These studies support the potential value of this novel drug delivery platform for treating pediatric cancers in general, and NB in particular.

show abstract

“…The main disadvantages of natural compounds are their low solubility and bioavailability, and inability to adhere to prescribed treatments. Nanotechnology is one of the new tools used for diagnosis, treatment, and prevention of cancer (Siddiqui et al, 2012). Therefore, nanotechnology offers another mode to improve the bioavailability of naturally active food ingredients.…”

Section: Anticancer Activity Of Apssmentioning

confidence: 99%

Extraction, isolation, identification, and bioactivity of polysaccharides from Antrodia cinnamomea

Dai,

Liu,

et al. 2023

Qual. Assur. Saf. Crops Foods

View full text Add to dashboard Cite

Antrodia (A) cinnamomea is a precious edible and medicinal mushroom and has attracted attention because of its rare resources and unique bioactivities. The bioactive compounds from the fruit body, mycelium, and fermentation broth of A. cinnamomea include triterpenoids, polysaccharides, antroquinonols, benzenoids, and succinic and maleic acid derivatives. Among these, polysaccharides are very important and are high-content bioactive compounds. The A. cinnamomea polysaccharides (APSs) present numerous biological activities, such as antiviral, anticancer, anti-inflammatory, antivascular, immunoregulation, antioxidant, and nerve protection. However, only few studies have focused only on APSs so far. Therefore, the cultivation methods, extraction, isolation, composition, structure, biological activity, and application of APSs are summarized in this review to provide a comprehensive and convenient reference for further research and development on APSs.

show abstract

Impact of nanotechnology in cancer: emphasis on nanochemoprevention

Cited by 35 publications

References 130 publications

Curcumin Nanomedicine: A Road to Cancer Therapeutics

Curcumin Nanomedicine: A Road to Cancer Therapeutics

Pre-Clinical Evaluation of rHDL Encapsulated Retinoids for the Treatment of Neuroblastoma

Extraction, isolation, identification, and bioactivity of polysaccharides from Antrodia cinnamomea

Contact Info

Product

Resources

About