Synergistic Anticancer Activity of Fluorescent Copper Nanoclusters and Cisplatin Delivered through a Hydrogel Nanocarrier

Ghosh, Rahul; Goswami, Upashi; Ghosh, Siddhartha Sankar; Paul, Anumita; Chattopadhyay, Arun

doi:10.1021/am505799q

Cited by 94 publications

(94 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…11 On the contrary, Copper NCs (CuNCs) are still rarely explored due to the limitations involved in their synthesis in controlling ultra fine size and their propensity to undergo oxidation. [11][12][13][14] Among different templates used for the synthesis of NCs, the small thiol group occupies seminal position due to its enhanced chemical stability, ultra fine size and tailorable surface properties. 12 However, there are very few reports in the literature on the synthesis of thiolate (like glutathione, GSH) protected CuNCs.…”

Section: Introductionmentioning

confidence: 99%

Luminescent Copper Nanoclusters as a Specific Cell-Imaging Probe and a Selective Metal Ion Sensor

et al. 2015

View full text Add to dashboard Cite

Copper nanoclusters (CuNCs) exhibit a high tendency to undergo oxidation particularly at the subnanometer size regime. In the light of overcoming this bottleneck, we have been successful in developing tripeptide (glutathione, GSH) templated CuNCs which show high biocompatibility and stability, in spite of being ultrafine in size. These blue-emitting CuNCs possess very promising optical features such as significant quantum yield (QY) and excellent photostability. Our cell-imaging studies reveal that the CuNCs localize primarily in nuclear membranes of the different cancerous (Hela, MDAMB-231, and A549) cells, and the cell viability assay conclusively established their nontoxic nature. Apart from their biological significances, these CuNCs also illustrate their ability to serve as a metal ion sensor, selectively detecting Fe 3+ ions in solution at the nanomolar concentration regime. This unique luminescent property of the NCs will enable them to serve as label-free and versatile probes having several biological and analytical applications.

show abstract

Section: Introductionmentioning

confidence: 99%

Luminescent Copper Nanoclusters as a Specific Cell-Imaging Probe and a Selective Metal Ion Sensor

et al. 2015

View full text Add to dashboard Cite

show abstract

“…In addition to biomacromolecules, synthetic polymers can be used as templates. This can be exemplified by the case of poly(vinylpyrrolidone) (PVP)‐templated Cu NCs . During synthesis, PVP is dissolved in a saturated sodium chloride solution, followed by the addition of Cu(II) chloride.…”

Section: Synthesis Of Cu Ncs As Theranostic Agentsmentioning

confidence: 99%

“…The excess amount of Cl − ions facilitates the formation of Cu(I) chloride, which is subsequently reduced to Cu(0) in the presence of ascorbic acid. This solution is then mixed with the dihydrolipoic acid (DHLA) solution, which is generated by reducing α‐lipoic acid to DHLA using sodium borohydride, to generate Cu NCs that are stabilized by PVP via weak coordination bonds . The NCs, however, are stable under aqueous conditions for only around two days.…”

Section: Synthesis Of Cu Ncs As Theranostic Agentsmentioning

confidence: 99%

“…One of the parameters determining the usability of the NCs in theranostic applications is the cluster stability, especially in an environment full of chemically and biochemically active species. This is particularly true when Cu NCs are concerned, owing to the susceptibility of Cu(0) to oxidation ( E 0 = 0.34 V) in comparison with Au ( E 0 = 1.50 V) and Ag ( E 0 = 0.80 V) . To address the instability issue, one strategy is to modify the surface of an NC with long‐chain alkanethiols (e.g., 1‐octanethiol, 1‐decanethiol, and 1‐dodecanethiol (DT)).…”

Section: Surface Engineering Of Cu Ncs For Theranosticsmentioning

confidence: 99%

See 1 more Smart Citation

Development of Copper Nanoclusters for In Vitro and In Vivo Theranostic Applications

2020

View full text Add to dashboard Cite

Theranostics refers to the incorporation of therapeutic and diagnostic functions into one material system. An important class of nanomaterials exploited for theranostics is metal nanoclusters (NCs). In contrast to gold and silver NCs, copper is an essential trace element for humans. It can be more easily removed from the body. This, along with the low cost of copper that offers potential large‐scale nanotechnology applications, means that copper NCs have attracted great interest in recent years. The latest advances in the design, synthesis, surface engineering, and applications of copper NCs in disease diagnosis, monitoring, and treatment are reviewed. Strategies to control and enhance the emission of copper NCs are considered. With this synopsis of the up‐to‐date development of copper NCs as theranostic agents, it is hoped that insights and directions for translating current advances from the laboratory to the clinic can be further advanced and accelerated.

show abstract

“…In a nanoporous particle‐supported lipid bilayer system, the combination of therapeutic agents (e.g., drugs, small interfering RNA, and toxins) and diagnostic agents (e.g., quantum dots) and simultaneous tumor targeting, endosomal escape and nuclear accumulation of selected cargos were achieved synergistically . Similar multifunctional nanoparticles have been used in a number of platinum drug delivery systems for great efficacy and reduced side effects (Figure ) …”

Section: Clinical Development and Perspectivementioning

confidence: 99%

Multifunctional platinum‐based nanoparticles for biomedical applications

Cheng

Liu

2016

WIREs Nanomed Nanobiotechnol

View full text Add to dashboard Cite

Platinum-based anticancer drugs play a central role in current cancer therapy. However, their applicability and efficacy are limited by drug resistance and adverse effects. Nanocarrier-based platinum drug delivery systems are promising alternatives to circumvent the disadvantages of bare platinum drugs. The various properties of nanoparticle chemistry allow for the trend toward multiple functionality. Nanoparticles preferentially accumulate at the tumor site through passive targeting, and the attachment of tumor targeting moieties further enhances their tumor-specific localization as well as tumor cell uptake. The introduction of stimuli-responsive groups into drug delivery systems can further achieve spatially and temporally controlled drug release in response to specific stimuli. Combination therapy strategies have been used to promote synergetic efficacy and overcome the resistance of platinum drugs. The tumor-localized drug delivery strategies exhibit benefits for preventing local tumor recurrence. In addition, the combination of platinum drugs and imaging agents in one unity allows the cancer diagnostics for real-time monitoring the distribution of drug-loaded nanoparticles inside the body and tumor. This review discusses recent scientific advances in multifunctional nanoparticle formulations of platinum drugs, and these designs exhibit new potential of multifunctional nanoparticles for delivering platinum-based anticancer drugs. WIREs Nanomed Nanobiotechnol 2017, 9:e1410. doi: 10.1002/wnan.1410 For further resources related to this article, please visit the WIREs website.

show abstract

Synergistic Anticancer Activity of Fluorescent Copper Nanoclusters and Cisplatin Delivered through a Hydrogel Nanocarrier

Cited by 94 publications

References 57 publications

Luminescent Copper Nanoclusters as a Specific Cell-Imaging Probe and a Selective Metal Ion Sensor

Luminescent Copper Nanoclusters as a Specific Cell-Imaging Probe and a Selective Metal Ion Sensor

Development of Copper Nanoclusters for In Vitro and In Vivo Theranostic Applications

Multifunctional platinum‐based nanoparticles for biomedical applications

Contact Info

Product

Resources

About