Synergistic antibacterial activity of PEGylated silver–graphene quantum dots nanocomposites

Habiba, Khaled; Bracho-Rincon, Dina P.; González-Feliciano, José A.; Villalobos‐Santos, Juan C.; Makarov, Vladimir I.; Ortiz, Darinel; Ávalos, Javier; González, Caleb; Weiner, Brad R.; Morell, Gerardo

doi:10.1016/j.apmt.2015.10.001

Cited by 140 publications

(63 citation statements)

References 56 publications

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“…Owing to their structural diversity, biodegradability, and non-toxicity, they are used in biomedical field. 19 Biosurfactants are proposed as suitable drug candidates against many diseases including cancer. 20,21 Literature showed cytotoxicity of these molecules against different cancer cell lines.…”

Section: Introductionmentioning

confidence: 99%

<p>Development of biosurfactant-based graphene quantum dot conjugate as a novel and fluorescent theranostic tool for cancer</p>

Bansal

Singh

Kumari

et al. 2019

IJN

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BackgroundBiosurfactants are amphipathic molecules of microbial origin that reduce surface and interfacial tension at gas–liquid–solid interfaces. Earlier, the biosurfactant was isolated and characterized in our laboratory from Candida parapsilosis. The property of the biosurfactant is further explored in this study by using quantum dots (QDs) as nanocarrier.Materials and methodsGraphene quantum dots (GQDs) were synthesized by bottom-up approach through pyrolysis of citric acid. GQDs were conjugated with both biosurfactant and folic acid (FA) using carbodiimide chemistry. The prepared GQD bioconjugate was studied for diagnostic and therapeutic effects against cancer cells.Results and discussionPhotoluminescence quantum yield (QY) of plain GQDs was measured as 12.8%. QY for biosurfactant conjugated GQDs and FA-biosurfactant conjugated GQDs was measured as 10.4% and 9.02%, respectively, and it was sufficient for targeting cancer cells. MTT assay showed that more than 90% of cells remained viable at concentration of 1 mg/mL, hence GQDs seemed to be non-toxic to cells. Biosurfactant conjugated GQDs caused 50% reduction in cellular viability within 24 hours. FA conjugation further increased the specificity of bioconjugated GQDs toward tumor cells, which is clearly evident from the drug internalization studies using confocal laser scanning microscopy. A higher amount of drug uptake was observed when bioconjugated GQDs were decorated with FA.ConclusionThe ability of GQD bioconjugate could be used as a theranostic tool for cancer. It is foreseen that in near future cancer can be detected and/or treated at an early stage by utilizing biosurfactant conjugated GQDs. Therefore, the proposed study would provide a stepping stone to improve the life of cancer patients.

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Section: Introductionmentioning

confidence: 99%

<p>Development of biosurfactant-based graphene quantum dot conjugate as a novel and fluorescent theranostic tool for cancer</p>

Bansal

Singh

Kumari

et al. 2019

IJN

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“…The mechanism of the antibacterial activity of AgNPs is complex, some authors have associated the high activity of AgNPs to that they act as a reservoir of silver ions that are released into the bacteria, interacting with the thiol groups of enzymes and proteins producing the inhibition of their functions . Other authors believe that nanoparticles can modulate signal transduction between bacteria stoping their growth, and finally, other authors have proposed that the formation of free radicals by nanoparticles can damage the cell membrane and make it porous …”

Section: Resultsmentioning

confidence: 99%

Stimuli‐sensitive nanostructured poly(sodium 4‐styrene sulfonate): Synthesis, characterization, and study of metal ion retention properties

Palencia

Córdoba

Arrieta

2017

J of Applied Polymer Sci

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Stimuli‐sensitive polymers are a type of smart polymers having the capability to change their configuration or properties under adequate stimuli as heat, pH, magnetic field, mechanical strength, among other. The aim of this work was to synthesize nanostructured polymers with antibacterial properties capable to change their retention properties of divalent metal ions by external stimuli (pH and ionic strength). For that, a polymerizable nanostructured crosslinker (PNC) based on silver nanoparticles (AgNPs) and acrylic acid was synthesized. Later, NPSS was synthesized by free‐radical polymerization, characterized by different analytical techniques and its retention properties of divalent ions (Cu2+, Fe2+, Mn2+, and Zn2+) were studied at different pHs and ionic strengths (5.0, 7.0, and 9.0; and 0.0, 0.5, and 1.5% NaCl, respectively). It was evidenced that AgNPs can be synthesized using acrylic acid as stabilizing agent, and later, be used for synthesis of NPSS by free‐radical polymerization. For NPSS, metal ion retention decreases as pH is increased; in addition, results suggest that the electrostatic interaction is not the only determining factor in the retention of ions. Other possible factors which would be affecting the retention are: water flow by swelling capacity and water flow by osmotic stress resulting of high salt concentration. NPSS showed antimicrobial activity against Escherichia coli and Staphylococcus aureus which was enhanced by incorporation of PNC based on AgNPs. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46001.

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“…Carbon dots can be applied for microbial imaging and evaluations, as well as killing of infectious organisms like E. coli, S. aureus, Pseudomonas aeruginosa and Candida albicans. These carbon dots can be applied in microbial detection, microbial viability assessments, gram-type identification, and biofilm imaging (Priyadarshini et al 2018;Habiba et al 2015;Lin et al 2019). Interestingly, the carbon dots platform has been harnessed fundamentally as a carrier for conventional disinfection agents to destroy bacteria, and also as a fluorescence label for analyzing the dead bacterial cells.…”

Section: Antimicrobial and Antiviral Effectsmentioning

confidence: 99%

Green synthesis, biomedical and biotechnological applications of carbon and graphene quantum dots. A review

2020

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Carbon and graphene quantum dots are prepared using top-down and bottom-up methods. Sustainable synthesis of quantum dots has several advantages such as the use of low-cost and non-toxic raw materials, simple operations, expeditious reactions, renewable resources and straightforward post-processing steps. These nanomaterials are promising for clinical and biomedical sciences, especially in bioimaging, diagnosis, bioanalytical assays and biosensors. Here we review green methods for the fabrication of quantum dots, and biomedical and biotechnological applications.

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Synergistic antibacterial activity of PEGylated silver–graphene quantum dots nanocomposites

Cited by 140 publications

References 56 publications

<p>Development of biosurfactant-based graphene quantum dot conjugate as a novel and fluorescent theranostic tool for cancer</p>

<p>Development of biosurfactant-based graphene quantum dot conjugate as a novel and fluorescent theranostic tool for cancer</p>

Stimuli‐sensitive nanostructured poly(sodium 4‐styrene sulfonate): Synthesis, characterization, and study of metal ion retention properties

Green synthesis, biomedical and biotechnological applications of carbon and graphene quantum dots. A review

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