Synergistic anti-tumor effect of mini-cells prepared from Salmonella typhimurium with mitomycin C in EL4-bearing mice

Kurashige, Satonori; Kodama, Kazue; Yoshida, Toshiharu

doi:10.1007/bf00205361

Cited by 3 publications

(4 citation statements)

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“…We reported previously that mini-cells enhanced the cytotoxic cellular immunity of lymphocyte and macrophage activities in normal mice [6] and that they had an inhibitory effect on tumor growth [5]. The synergistic antitumor effect of combination therapy with mini-cells and mitomycin C was also observed in EL4-bearing mice, and about half the EL4-bearing mice survived over 40 days [8]. We considered at that time that the antitumor effect was mostly attributable to the restoration of macrophage activity, because macrophage activity was more rapidly inhibited than lymphocyte activities in $180-and EL4-bearing mice [4].…”

Section: Discussionmentioning

confidence: 71%

“…We considered at that time that the antitumor effect was mostly attributable to the restoration of macrophage activity, because macrophage activity was more rapidly inhibited than lymphocyte activities in $180-and EL4-bearing mice [4]. Immunotherapy with mini-cells and mitomycin C might induce a synergistic antitumor effect through macrophage activation and direct cytotoxicity of mitomycin C to the tumor cells [8].…”

Section: Discussionmentioning

confidence: 99%

“…We reported also that the effect of mini-cells and mitomycin C on inhibition the subcutaneous growth of EL4 cells was synergistic [8].…”

Section: Introductionmentioning

confidence: 96%

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Synergistic anti-suppressor effect of mini cells prepared from Salmonella typhimurium and mitomycin C in EL 4-bearing mice

Kurashige

Akuzawa

Mitsuhashi³

1985

Cancer Immunol Immunother

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The subcutaneous growth of EL4 cells was significantly accelerated when they were injected together with spleen cells collected from mice which had received EL4 cells SC 14 days previously, and all mice died within 18 days after receiving this mixture; 80% of mice which received a mixture of EL4 and spleen cells collected immediately after EL4 graft survived over 40 days. Spleen cells collected 14 days after EL4 graft suppressed the blastogenic responses of normal spleen lymphocytes to concanavalin A, pokeweed mitogen, and lipopolysaccharide of Escherichia coli in a mixed culture system. Acceleration of tumor growth was retarded when EL4 cells were injected together with spleen cells from EL4-bearing mice treated with both Salmonella typhimurium mini-cells and mitomycin C, and 60% of mice survived over 40 days. Blastogenic responses of normal spleen lymphocytes mixed with spleen cells from EL4-bearing mice treated with both mini-cells and mitomycin C were restored almost to control levels. The results suggest that combination treatment with mini-cells and mitomycin C synergistically inhibits the induction of suppressor cells in EL4-bearing mice.

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Section: Discussionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 99%

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Synergistic anti-suppressor effect of mini cells prepared from Salmonella typhimurium and mitomycin C in EL 4-bearing mice

Kurashige

Akuzawa

Mitsuhashi³

1985

Cancer Immunol Immunother

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“…Immunostimulants exhibiting such effects include various synthetic products, i.e., levamisole [8,20,21], poly I : C [21], and bacteria and bacterial products, e.g., Bacillus Calmette-Gu&in (BCG) [3,13,14,17], Corynebacterium parvum [6,15], Salmonella typhimurium [11,12], genus Nocardia [1,2,4]. The antitumor activities of some of these agents have been far from satisfactory, and the side-effects of some of the agents are severe [22].…”

Section: Introductionmentioning

confidence: 99%

Augmentation of antitumor resistance by a strain of unicellular green algae, Chlorella vulgaris

Tanaka

Konishi

Himeno

et al. 1984

Cancer Immunol Immunother

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Growth of Meth-A tumor in CDF1 mice was inhibited significantly by injection of a hot water extract of a strain of Chlorella vulgaris (CE) into the tumor or into the subcutaneous tissue near the tumor. The augmentation of resistance by CE may require the participation of T cells and macrophages, since it was abolished or reduced in athymic nude mice or mice treated with carrageenan, a macrophage blocker. Mice treated with CE exhibited antigen-specific augmented resistance against rechallenge with tumor. Moreover, the antitumor effect of CE was comparable with that of Corynebacterium parvum, but its mechanism of effect might be different.

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Development of Salmonella Strains as Cancer Therapy Agents and Testing in Tumor Cell Lines

Eisenstark

Kazmierczak

Dino

et al. 2007

Methods in Molecular Biology

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Despite significant progress in the development of new drugs and radiation, deaths due to cancer remain high. Many novel therapies are in clinical trials and offer better solutions, but more innovative approaches are needed to eradicate the various subpopulations that exist in solid tumors. Since 1997, the use of bacteria for cancer therapy has gained increased attention. Salmonella Typhimurium strains have been shown to have a remarkably high affinity for tumor cells. The use of bacterial strains to target tumors is a relatively new research method that has not yet reached the point of clinical success. The first step in assessing the effectiveness of bacterial tumor therapy will require strain development and preclinical comparisons of candidate strains, which is the focus of this chapter. Several investigators have developed strains of Salmonella with reduced toxicity and capacity to deliver anti-tumor agents. Although methods for obtaining safe therapeutic strains have been relatively successful, there is still need for further genetic engineering before successful clinical use in human patients. As described by Forbes et al. in 2003, the main stumbling block is that, while bacteria preferentially embed within tumor cells, they fail to spread within the tumor and finish the eradication process. Further engineering might focus on creating Salmonella that remove motility limitations, including increased affinity toward tumor-generated chemotactic attractants and induction of matrix-degrading enzymes.

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Synergistic anti-tumor effect of mini-cells prepared from Salmonella typhimurium with mitomycin C in EL4-bearing mice

Cited by 3 publications

References 3 publications

Synergistic anti-suppressor effect of mini cells prepared from Salmonella typhimurium and mitomycin C in EL 4-bearing mice

Synergistic anti-suppressor effect of mini cells prepared from Salmonella typhimurium and mitomycin C in EL 4-bearing mice

Augmentation of antitumor resistance by a strain of unicellular green algae, Chlorella vulgaris

Development of Salmonella Strains as Cancer Therapy Agents and Testing in Tumor Cell Lines

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