Augmentation of antitumor resistance by a strain of unicellular green algae, Chlorella vulgaris

Tanaka, Kuniaki; Konishi, Fumiko; Himeno, Kunisuke; Taniguchi, Kazuto; Nomoto, Kikuo

doi:10.1007/bf00200042

Cited by 70 publications

(31 citation statements)

References 15 publications

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“…Dietary administration of inulin resulted in increase of faecal lactobacilli and bifidobacteria and in decrease of clostridia, gram-positive cocci, and Bacteroides ( Mitsouka et al, 1987;Kleessen et al, 1997;Harmsen et al, 2002). Alginate is considered to influence digestibility and availability of nutrients from the diet (Terada et al, 1995;Bach Knudsen, 2001;Drochner et al, 2004) and for the unicellular microalga Chlorella vulgaris immunemodulating and anti-cancer properties have been reported (Tanaka et al, 1984(Tanaka et al, , 1986Noda et al, 1996;Yasukawa et al, 1996;Justo et al, 2001). Active components of essential oils are known to have antioxidative (Grassmann et al, 2001) and anti-inflammatory (Santos and Rao, 2000;Peana et al, 2002;Kim et al, 2003) effects.…”

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confidence: 99%

Effect of dietary natural supplements on immune response and mineral bioavailability in piglets after weaning

Ţăranu¹,

Marin²,

Untea³

et al. 2012

CZECH J ANIM SCI

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Plants and plant extracts (PPEs) have gained increasing interest as feed additives and possible replacing antibiotics for pig productions. The effects of dietary Chlorella vulgaris (1%), sodium alginate (0.1%), inulin (1.5%), and a mixture of essential oils (0.04%) supplements on immune response, and bioavailability of some micronutrients (iron − Fe, copper − Cu, manganese − Mn, and zinc − Zn) were investigated in weaned piglets in this study. The results showed that the concentration of IgG was increased in the plasma of pigs fed the PPEs supplemented diets being significantly higher (P < 0.05) in the case of dietary sodium alginate supplementation in comparison to the control (6.00 vs. 4.03 mg/ml). In liver, PPEs, especially inulin and essential oils, were able to modulate the level of cytokine production and mineral retention, resulting in higher liver concentration of IL-1β (125.4 and 88.9%), IL-8 (136.9 and 61.3%), TNF-a (296.6 and 121.6%), and IFN-γ (51.2 and 107.28%), Cu (71.31 ppm), and Fe (192.56 ppm) in comparison to the control. The results of this experiment indicate that natural supplements investigated herein, especially inulin, essential oils, and sodium alginate had the ability to potentiate both the immune function and mineral retention during the initial post weaning period.

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confidence: 99%

Effect of dietary natural supplements on immune response and mineral bioavailability in piglets after weaning

Ţăranu¹,

Marin²,

Untea³

et al. 2012

CZECH J ANIM SCI

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“…1 and 2) and following intratumor injection to CDF1 mice bearing SC-inoculated tumor [23], while systemic injections of CE were not so effective (data were not shown). Several possible explanations might be considered for these results, viz.…”

Section: Effects Of Ip Injection Of Ce On Cellular Accumulation In Thmentioning

confidence: 52%

“…W e came to the following conclusions: (1) C E induced antitumor elements at the site of C E injection; (2) tumor cells were killed directly by CE; or (3) C E induced an alteration of the microenvironment, making it unsuitable for tumor establishment. W e have shown in a previous paper [23] that the antitumor effect of intratumorally injected C E on SC-inoculated tumor is mediated by host defense.…”

Section: Discussionmentioning

confidence: 97%

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Antitumor effect induced by a hot water extract of Chlorella vulgaris (CE): Resistance to meth-A tumor growth mediated by CE-induced polymorphonuclear leukocytes

Konishi

Tanaka

Himeno

et al. 1985

Cancer Immunol Immunother

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When a hot water extract of Chlorella vulgaris (CE) was injected into the peritoneal cavity of BALB/c mice inoculated with syngeneic Meth-A tumor cells, the survival times were strikingly prolonged. Furthermore, peritoneal exudate cells (PEC) rich in polymorphonuclear cells (PMN) obtained from normal mice 24 h after CE injection exhibited an antitumor effect in a Winn-type assay using normal recipients. Such an activity of PEC remained almost intact after T cell or macrophage depletion. However, such PEC did not express an antitumor effect in a Winn-type assay using irradiated recipients. It was suggested that CE-induced PEC, presumably PMN, expressed an antitumor effect in cooperation with a host- or recipient-derived element(s) sensitive to irradiation. The antitumor mechanism of CE may be different from that of OK-432, one of the biological response modifiers.

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“…Their ecological positions at the base of most food webs and their essential roles in nutrient cycling and oxygen production are critical to all ecosystems. Many reports showed that, algae are rich in natural products such as antibiotics (Bloor and England, 1989;Issa, 1999;Fathi and Al-Kahtani, 2010), Antitumor (Tanaka et al, 1984;Morimoto et al, 1995;Suzuki et al, 1999;Teneva et al, 2013) and antiviral (Ohta et al, 1998;Priyadarshani and Rath, 2012;Abdo et al, 2012). Also many studies confirmed their ability to control pathogenic fungi (Martin, 1995;AboShady et al, 2007;Abedin and Taha, 2008).…”

Section: Introductionmentioning

confidence: 99%

Toxicity of Some Microalgae to the Citrus Brown Mite Eutetranychus Orientalis (Klein)

Shosha

Taha

Fawzy

2013

Al-Azhar Bulletin of Science- Basic Science Sector

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The citrus brown mite Eutetranychus orientalis is a common spider mite, which is a harmful pest in citrus orchards in Egypt. The toxic activities of some microalgae isolated from Egyptian soils and water are studied against E. orientalis. The toxicity of whole cultures (culturing broth and cell) of seven algal strains was tested against E. orientalis. Three strains out of the tested seven strains showed higher toxicity with mortality percentage reached up to 99 % after 72 h recorded against adult individuals of E. orientalis with a strain of Chlorella minutissima. The toxic activity was also tested against immature individuals and eggs of E. orientalis. The highest mortality percent against immature individuals was observed with C. oocystoids. Eggs were not affected with any of the tested algal strains. When cells and culturing broth were tested separately the activity was higher in culturing broth which means that this activity is due to some extracellular metabolites secreted by algae in their culturing medium. When the organic solvent n-butanol was used to extract the active constituents from the whole cultures (culturing broth and cell), the activity was found to be higher in aqueous phase compared to the butanolic phase.

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Augmentation of antitumor resistance by a strain of unicellular green algae, Chlorella vulgaris

Cited by 70 publications

References 15 publications

Effect of dietary natural supplements on immune response and mineral bioavailability in piglets after weaning

Effect of dietary natural supplements on immune response and mineral bioavailability in piglets after weaning

Antitumor effect induced by a hot water extract of Chlorella vulgaris (CE): Resistance to meth-A tumor growth mediated by CE-induced polymorphonuclear leukocytes

Toxicity of Some Microalgae to the Citrus Brown Mite Eutetranychus Orientalis (Klein)

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