Synergistic ameliorative effects of sesame oil and alpha-lipoic acid against subacute diazinon toxicity in rats: hematological, biochemical, and antioxidant studies

Abdel-Daim, Mohamed M.; Taha, Ramadan; Ghazy, Emad; El‐Sayed, Yasser S.

doi:10.1139/cjpp-2015-0131

Cited by 70 publications

(25 citation statements)

References 41 publications

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“…Furthermore, cardiac injury caused by acute ischemic stroke could be attributed, at least in part, to oxidative stress. Similar increases in CK-MB, CK, and LDH levels have been attributed to oxidative stress by a number of studies [30, 31, 36]. A previous study showed that vitamin C (an antioxidant) decreased CK-MB, CK, and LDH levels in mice models of cardiotoxicity, supporting the oxidative stress hypothesis of cardiotoxicity [30].…”

Section: Discussionsupporting

confidence: 58%

“…The myocardial tissue showed histopathological changes that are characteristics of myocardial damage, as supported by higher CK-MB activity and CK and LDH levels in the serum of the rats of the 6h-ischemia group [30, 31]. MF and HF were depressed in ECG recording, but the MF/TF ratio remained unchanged after brain ischemia, suggesting that the balance of the autonomic nervous system was not altered.…”

Section: Discussionmentioning

confidence: 99%

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Kudiezi injection mitigates myocardial injury induced by acute cerebral ischemia in rats

Liu

Tao

Wang

et al. 2017

BMC Complement Altern Med

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BackgroundKudiezi (KDZ) injection is commonly used in traditional Chinese medicine as treatment for cerebral infarction and angina pectoris. The present study investigated the therapeutic effects of KDZ injection on myocardial injury induced by acute cerebral ischemia and the possibly protective mechanisms.MethodsRats were divided into three groups: sham, 6h-ischemia, and KDZ treatment (KDZ). The neurological deficits were determined by the Garcia score. The cerebral infarct volume was measured by 2,3,5-triphenyltetrazolium chloride (TTC) staining, and brain water content was also evaluated. Serum creatinine kinase (CK), lactate dehydrogenase (LDH), and creatine kinase-myocardial band (CK-MB) activity, myocardial tissue malondialdehyde (MDA) levels, L-Glutathione (GSH) levels, and superoxide dismutase (SOD) activity as well as mitochondrial cytochrome c oxidase (COX) activity were determined. Mitochondrial COX I and COX III mRNA expressions of myocardial tissues were measured by RT-PCR.ResultsImpaired neurological function and brain edema were observed in the 6h-ischemia group. TTC staining showed that the 6h-ischemia group had larger infarct zones than the sham group. Myocardial ischemic changes (widened myocardial cell gap, cracks, and obvious edema) were detected in the 6h-ischemia group compared with the sham group, with elevated serum CK-MB activity and CK and LDH levels. Electrocardiography showed lower medium frequency (MF) and high frequency (HF) in the 6h-ischemia group compared with the sham group. In myocardial tissue, COX activity was elevated in the 6h-ischemia compared with the sham group, while SOD, GSH, and MDA levels, and COX I and COX III mRNA expressions remained unchanged. KDZ injection decreased neurological impairment, brain edema, gaps between cells, and infarct size. Compared with the 6h-ischemia group, it reduced serum CK-MB activity and CK and LDH levels, and MDA levels in myocardial tissue. KDZ significantly increased GSH levels, SOD activity, and mitochondria COX activity and the expression of COX I and COX III mRNA in myocardial tissue compared with the sham group.ConclusionKDZ injection had a protective effect against cerebral ischemia in rats. KDZ injection could also alleviate myocardial injury after acute cerebral ischemia in rats. The possible mechanisms involve the regulation of the oxidative stress/antioxidant capacity after cerebral ischemia.

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Section: Discussionsupporting

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Kudiezi injection mitigates myocardial injury induced by acute cerebral ischemia in rats

Liu

Tao

Wang

et al. 2017

BMC Complement Altern Med

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“…SOD catalyzes the conversion of superoxide radical to hydrogen peroxide while CAT converts the later into water. These antioxidant enzymes can, therefore, alleviate the toxic effects of ROS Abdel-Daim et al, 2015). SOD and CAT activities were significantly reduced in rats treated with CPF, ABM, and their combination.…”

Section: Discussionmentioning

confidence: 95%

Neuro and renal toxicity induced by chlorpyrifos and abamectin in rats

Nasr

El‐Demerdash

El-Nagar

2015

Environ Sci Pollut Res

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Oxidative stress by increased production of reactive oxygen species has been implicated in pesticides toxicity. This study focused on the toxicological effects of chlorpyrifos, an organophosphate insecticide and abamectin, a biocide each alone or in combination on antioxidant status, and oxidative stress biomarkers in brain and kidney. Animals were divided into four groups. The first group was used as control while groups 2, 3, and 4 were treated with chlorpyrifos (CPF; 14.9 mg/kg BW), abamectin (ABM; 30 mg/kg BW), and chlorpyrifos plus abamectin, respectively. Rats were treated daily with the tested compounds by oral gavages for 30 days. Results revealed that thiobarbituric acid-reactive substances (TBARS) levels were significantly increased in brain and kidney due to insecticides administration. On the other hand, reduced glutathione (GSH) and protein contents in addition to the activities of antioxidant enzymes, alkaline phosphatase (ALP), and acetylcholinesterase (AChE) were significantly decreased in rat organs. A significant induction in lactate dehydrogenase (LDH) activity, urea, and creatinine levels were also observed. The response was more pronounced in rats treated with both CPF and ABM. Results showed that the used insecticides had the propensity to cause significant oxidative damage in rat brain and kidney which is associated with marked perturbations in antioxidant defense system. It can be concluded that antioxidant enzymes can be used as potential biomarkers of toxicity associated with pesticides exposure.

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“…Also, our histopathological findings showed mild lesion in mixed treated groups as compared to TAAintoxicated group. The ability of ALA to ameliorate the TAA-induced elevation in serum liver enzymes, bilirubin, might be correlated to both its radical scavenging properties, indirect effect as a regulator of antioxidative systems (Abdel-Daim et al, 2015 andEl-Feki et al, 2016). The beneficial hypolipidemic effects of ALA were in accordance with the results obtained by Mythili et al (2006), who found that ALA supplementation was effective against cyclophosphamide-induced dyslipidemia.…”

Section: Discussionmentioning

confidence: 99%

Potential Ameliorative Effects of Alpha Lipoic Acid and Silymarin on Thioacetamide-Induced Hepatic Damage in Rats

Salama¹,

Oda²,

Khafaga³

et al. 2017

AJVS

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Key words:liver, thioacetamide, silymarin, alpha lipoic acid, rats.The present study was designed to study the ameliorative role of alpha lipoic acid (ALA) and silymarin (SIL) against thioacetamide (TAA)-induced hepatic damage. Sixty male albino rats were randomly separated into 6 groups (n=10); control group, TAA-treated group: received intraperitoneal injection of TAA 250 mg/kg bwt/day three times a week, ALAtreated group: received ALA 100 mg/kg bwt/day) orally three times a week, SIL-treated group: received SIL 100 mg/kg bwt/day orally three times a week, TAA+ALA-treated group, and TAA+SIL-treated group at the same previous doses and routes for ten weeks. Results showed that TAA induced a significant elevation in total and direct bilirubin, total cholesterol and triglycerides levels and serum liver enzymes after four and ten weeks of the treatments. While the serum levels of total proteins, albumin and high density lipoproteincholesterol revealed a significant decrease. TAA injection resulted in an increase in the hepatic lipid peroxidation and decreased levels of antioxidant biomarker. Histopathologically, TAA revealed marked degenerative, necrotic and fibrotic alterations in the liver, particularly during ten weeks post-treatment. ALA and SIL-treatment ameliorated TAA-induced oxidative damage, alterations in the liver function tests and liver histopathology. However, ALA demonstrated better hepatic protection against TAAinduced liver damage as compared to SIL. The study clearly concluded that ALA has more powerful antioxidant properties than SIL.

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Synergistic ameliorative effects of sesame oil and alpha-lipoic acid against subacute diazinon toxicity in rats: hematological, biochemical, and antioxidant studies

Cited by 70 publications

References 41 publications

Kudiezi injection mitigates myocardial injury induced by acute cerebral ischemia in rats

Kudiezi injection mitigates myocardial injury induced by acute cerebral ischemia in rats

Neuro and renal toxicity induced by chlorpyrifos and abamectin in rats

Potential Ameliorative Effects of Alpha Lipoic Acid and Silymarin on Thioacetamide-Induced Hepatic Damage in Rats

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