Synergistic Action of Vitamin E and Vitamin C in Vivo Using a New Mutant of Wistar-Strain Rats, ODS, Unable to Synthesize Vitamin C.

Igarashi, Osamu; Yonekawa, Yukako; Fujiyama-Fujihara, Yoko

doi:10.3177/jnsv.37.359

Cited by 51 publications

(20 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Feeding high vitamin C levels (10-25 times the vitamin C requirement for teleosts, NRC 1993) along with a vitamin E supplement contributed to an increased a-T concentration in the liver as compared to feeding no vitamin C. This supports the hypothesis that a-T is regenerated by AA in vivo (Igarashi et al 1991;Hamre et al 1997). In sturgeon fed the high vitamin C supplementation, endogenous a-T oxidation and in vitro phospholipid peroxidation were promoted in the liver when vitamin E was withdrawn from the diet, suggesting that high doses of vitamin C may be prooxidant.…”

Section: Discussionsupporting

confidence: 72%

Vitamin C - vitamin E interaction in juvenile lake sturgeon (Acipenser fulvescens R.), a fish able to synthesize ascorbic acid

et al. 1999

View full text Add to dashboard Cite

Summary The hypothesis that vitamin C interacts with vitamin E in vivo was investigated in juvenile lake sturgeon. Ten‐month old lake sturgeon were fed diets supplemented with either 0 or 1250 mg ascorbic acid/kg diet concomitantly with either 0 or 200 mg α tocopherol/kg diet for 7 weeks at 17°C. Dietary vitamin C supplement resulted in significant increases of ascorbate concentrations in the posterior kidney and liver of sturgeon. Dietary vitamin E omission affected liver concentrations of α‐tocopherol (10.0 ± 4.5 μg/g) in comparison to sturgeon fed a diet supplemented with vitamin E and vitamin C (99.5 ± 22.9 μg/g). Dietary vitamin C supplement decreased liver α‐tocopherol concentration in vitamin E‐deprived sturgeon. Also, vitamin E supplement lowered posterior kidney and liver ascorbic acid concentrations in vitamin C‐deprived sturgeon. Gulonolactone oxidase and dehydroascorbic acid reductase activities were stimulated in groups fed vitamin C. Thiobarbituric acid‐reactive substances concentrations (an indicator of lipid peroxidation) were higher in sturgeon fed either of vitamins as compared to sturgeon deprived of both vitamins. The results suggested that large doses of vitamins C and E may be prooxidant in vivo.

show abstract

Section: Discussionsupporting

confidence: 72%

Vitamin C - vitamin E interaction in juvenile lake sturgeon (Acipenser fulvescens R.), a fish able to synthesize ascorbic acid

et al. 1999

View full text Add to dashboard Cite

show abstract

“…18,19 A significant increase in fracture healing in rabbits receiving α-tocopherol was detected in our study. A positive effect of α-tocopherol on fracture healing was also described previously using a rabbit model.…”

Section: Discussionmentioning

confidence: 54%

Histological Assessment of the Effect of α-Tocopherol on Fracture Healing in Rabbits

et al. 2003

View full text Add to dashboard Cite

To investigate the effect of a-tocopherol (vitamin E) on fracture healing in rabbits, two groups of 10 rabbits were either injected with a-tocopherol (treated) or untreated (controls). The right femurs of both groups were fractured, and the treated group were injected intramuscularly with 20 mg/kg a-tocopherol daily for 5 days starting on the day of fracture. After 21 days, histological sections of the fractured region were examined and scored. Fracture healing had progressed further in the a-tocopherol group than in the control group. A statistically significant difference between the histological grading of fracture healing in the two groups was found. This difference may result from an antioxidant (a-tocopherol) effect on free oxygen radicals in the fracture area. We conclude that a-tocopherol may affect fracture healing favourably and might be useful as a therapeutic agent in clinical fracture management.

show abstract

“…In conclusion, the effects of vitamin C deficiency on the lipoprotein metabolism become more distinct with greater vitamin E deficiency, It is unclear whether this phenomenon is due to a synergistic action of vitamin C and vitamin E, a type of action noted previously by Igarashi et al in ODS rats (17), or whether it is a result of actions by these vitamins that are independent of each other. A clarification of the mechanism underlying this phenomenon would be an interesting subject for future investigations.…”

Section: Discussionmentioning

confidence: 64%

Effect of Deficiency of Vitamins C and/or E on Lipoprotein Metabolism in Osteogenic Disorder Shionogi Rat, a Strain Unable to Synthesize Ascorbic Acid.

Kamiyama

Howlader

Ito

et al. 2002

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

View full text Add to dashboard Cite

SummaryThe effects of vitamin C and/or E deficiency on lipoprotein metabolism were investigated in the inherently scorbutic Osteogenic Disorder Shionogi (ODS) rat. In the vita min C-deficient (C-def) group, marked increases in plasma VLDL and LDL cholesterol were observed (by comparison with the vitamins C and E-sufficient control group). In rats kept deficient in both vitamin C and vitamin E (C, E-def ), LDL cholesterol was significantly higher than in the C-def group even though the levels of VLDL and HDL cholesterol were similar be tween the two groups. TBARS values for the LDL fraction in the C-def group were of the same magnitude as in the E-def group, and these values were significantly higher than those obtained for the control group. In the C, E-def group, the values were even higher than in the E-def and C-def groups. The nondenatured PAGE of the LDL fraction indicated the appear ance of HDLG in the C-def and C, E-def groups. The SDS-PAGE of the LDL fraction showed in creased apo B-48 in the C-def and C, E-def groups and increased apo E in the C,E-def group. Decreased plasma LCAT activity in the E-def, C-def, and C, E-def groups indicated an alter ation in HDL metabolism as a result of oxidation. These results suggest that lipid peroxida tion and some distinct features of lipoprotein metabolism resulting from vitamin C defi ciency become more significant when vitamin E is also deficient along with vitamin C defi ciency.

show abstract

Synergistic Action of Vitamin E and Vitamin C in Vivo Using a New Mutant of Wistar-Strain Rats, ODS, Unable to Synthesize Vitamin C.

Cited by 51 publications

References 18 publications

Vitamin C - vitamin E interaction in juvenile lake sturgeon (Acipenser fulvescens R.), a fish able to synthesize ascorbic acid

Vitamin C - vitamin E interaction in juvenile lake sturgeon (Acipenser fulvescens R.), a fish able to synthesize ascorbic acid

Histological Assessment of the Effect of α-Tocopherol on Fracture Healing in Rabbits

Effect of Deficiency of Vitamins C and/or E on Lipoprotein Metabolism in Osteogenic Disorder Shionogi Rat, a Strain Unable to Synthesize Ascorbic Acid.

Contact Info

Product

Resources

About