Synergism between 4-Hydroxyquinoline and Pyridone Coccidiostats

Anticoccidial drugs of the livestock industry

“…It is a derivative of salinomycin having an additional methyl group, therefore alternatively called (4S)-4-methyl salinomycin. When combining different ionophores with nicarbazin, Challey and Jeffers (1973) found that combinations of nicarbazin and narasin had synergistic activity. A combination product containing both active pharmaceutical ingredients (API) in 1:1 ratio was developed (Maxiban®).…”

“…by inhibiting mitochondrial energy production in sporozoites and trophozoites (Kant et al 2013). A synergistic effect between meticlorpindol and 4-hydroxyquinolones has been described (Challey and Jeffers 1973; Jeffers and Challey 1973). To achieve complete control, combination products with quinolones are marketed.…”

Coccidiosis in poultry: anticoccidial products, vaccines and other prevention strategies

“…Similar to the quinolones, it inhibits electron transport in mitochondria, but possibly at another level as cross-resistance with quinolones does not occur. A synergistic effect between meticlorpindol and 4-hydroxiquinolones has been described (Challey and Jeffers 1973). A widely used pyridone-quinolone combination drug is Lerbek Õ , consisting of meticlorpindol and methyl benzoquate.…”

Buquinolate as a preventive drug to control microsporidosis in the blue crab

“…Synergism between drugs allows a much lower concentration of drugs to be used. Challey and Jeffers (1973) reported a drastic decrease in production of Eimeria acervulina Tyzzer oocysts in chicks given a combination of meticlorpindol and buquinolate than in those given either drug alone. This same drug, under the generic name clopidol (3,5-dichloro-2,6 dimethyl-4-pyridinol), did not enhance the effect of buquinolate on N. michaelis.…”