2015
DOI: 10.1186/s40409-015-0048-1
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Abstract: BackgroundRabies is an incurable neglected zoonosis with worldwide distribution characterized as a lethal progressive acute encephalitis caused by a lyssavirus. Animal venoms and secretions have long been studied as new bioactive molecular sources, presenting a wide spectrum of biological effects, including new antiviral agents. Bufotenine, for instance, is an alkaloid isolated from the skin secretion of the anuran Rhinella jimi that inhibits cellular penetration by the rabies virus. Antimicrobial peptides, su… Show more

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Cited by 18 publications
(10 citation statements)
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References 22 publications
(28 reference statements)
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“…Cecropins, isolated mostly from the hemolymph of infected pupae of the silk moth Hyalophora cecropia, but also from other insects, tunicates and Ascaris nematodes, are a family of AMPs, containing 35-37 amino acid residues arranged in two amphiphilic α-helices linked by a Gly-Pro hinge. Synthetic hybrid peptides, namely cecropin A (1-8)-magainin 2 (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12), exhibited potent antiviral activity by a mechanism mainly based on the compound hydrophobicity and α-helical content, inhibiting the virushost cell fusion [85] (Table 2).…”
Section: Insect Venomsmentioning
confidence: 99%
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“…Cecropins, isolated mostly from the hemolymph of infected pupae of the silk moth Hyalophora cecropia, but also from other insects, tunicates and Ascaris nematodes, are a family of AMPs, containing 35-37 amino acid residues arranged in two amphiphilic α-helices linked by a Gly-Pro hinge. Synthetic hybrid peptides, namely cecropin A (1-8)-magainin 2 (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12), exhibited potent antiviral activity by a mechanism mainly based on the compound hydrophobicity and α-helical content, inhibiting the virushost cell fusion [85] (Table 2).…”
Section: Insect Venomsmentioning
confidence: 99%
“…All these facts together have propelled the prospection for new antiviral drugs, particularly from natural products, as they constitute more than 25% of the new drug prototypes approved in the last decades [4]. Among sources of natural products, animal venoms have revealed a great potential for drug discovery [5][6][7], and despite the harmful action mechanism of animal venoms, most of them have components holding potential medicinal properties to cure diseases.…”
Section: Introductionmentioning
confidence: 99%
“…Ocellatin-F1, previously known as fallaxin, was originally found in the skin secretion of Leptodactylus fallax and it was also recently isolated from the skin secretion Leptodactylus labyrinthicus [24, 26]. Whereas this peptide was active against bacteria, no activity against the tested fungal strains was observed [24].…”
Section: Resultsmentioning
confidence: 99%
“…Whereas this peptide was active against bacteria, no activity against the tested fungal strains was observed [24]. Besides, Cunha Neto et al [26] have noted a synergic antiviral effect between ocellatin-F1 and the alkaloid bufotenine, since combinations of these compounds lead to pronounced inhibition of BHK-21 cellular infection promoted by the rabies virus. Cunha Neto et al [26] also mentioned the isolation of a truncated peptide sequence, which corresponds to ocellatin-F1 deprived from Lys and Leu residues at the peptide C-terminus, although no biological activity assays with this peptide have been reported up to our knowledge.…”
Section: Resultsmentioning
confidence: 99%
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