Synergic antioxidant activity of γ-terpinene with phenols and polyphenols enabled by hydroperoxyl radicals

Guo, Yafang; Baschieri, Andrea; Amorati, Riccardo; Valgimigli, Luca

doi:10.1016/j.foodchem.2020.128468

Cited by 58 publications

(50 citation statements)

References 40 publications

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“…They are classified as terpene groups and can be found in large amounts in M. cajuputi leaves EO. Many previous studies reported that these compounds have a strong AC [18][19][20]. Essentially, there are no published studies on the AC of M. cajuputi leaves EO in the literature, it was not possible to compare our results.…”

Section: Determination Of the Chemical Compositions Of M Cajuputi Leaves Eo Gc-ms Analysis Was Usedmentioning

confidence: 74%

Physicochemical properties, chemical components, and antibacterial activity of Melaleuca cajuputi Powell essential oil leaves from Quang Tri Province, Vietnam

Quoc¹

2022

Bull. Chem. Soc. Eth.

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ABSTRACT. Essential oil (EO) was extracted from Melaleuca cajuputi Powell leaves using the steam distillation method. The main aim of this study is to determine several physicochemical properties of EO, including acid value, saponification value, ester value, relative density, absolute density, and freezing point. In addition, the chemical components were also analyzed using the gas chromatography–mass spectrometry (GC–MS) method. The obtained 1,8-cineol content is quite high (71.83%). In addition, these components in EO had an antioxidant capacity and antibacterial activity, including gram-positive and gram-negative bacteria (using the paper disc diffusion method for antibiotic susceptibility testing). Particularly, this EO inhibited the growth of Escherichia coli (ATCC 25922), Salmonella enteritidis (ATCC 13076), and Staphylococcus aureus (ATCC 25923). KEY WORDS: Antimicrobial activity, Antioxidant capacity, GC-MS, Essential oil, Melaleuca cajuputi Powell. Bull. Chem. Soc. Ethiop. 2021, 35(3), 677-683. DOI: https://dx.doi.org/10.4314/bcse.v35i3.18

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Section: Determination Of the Chemical Compositions Of M Cajuputi Leaves Eo Gc-ms Analysis Was Usedmentioning

confidence: 74%

Physicochemical properties, chemical components, and antibacterial activity of Melaleuca cajuputi Powell essential oil leaves from Quang Tri Province, Vietnam

Quoc¹

2022

Bull. Chem. Soc. Eth.

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“…We tested the EOs in the controlled autoxidation of a kinetically characterized oxidizable substrate, which is the best-established approach for quantitative testing [ 16 , 18 , 31 ]. This test was based on monitoring the progress of the autoxidation of a reference substrate by measuring the rate of oxygen consumption in the presence and absence of the test antioxidant.…”

Section: Resultsmentioning

confidence: 99%

Absolute Antioxidant Activity of Five Phenol-Rich Essential Oils

Guo

Pizzol

Gabbanini³

et al. 2021

Molecules

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Essential oils (EOs) have promising antioxidant activities which are gaining interest as natural alternatives to synthetic antioxidants in the food and cosmetic industries. However, quantitative data on chain-breaking activity and on the kinetics of peroxyl radical trapping are missing. Five phenol-rich EOs were analyzed by GC-MS and studied by oxygen-uptake kinetics in inhibited controlled autoxidations of reference substrates (cumene and squalene). Terpene-rich Thymus vulgaris (thymol 4%; carvacrol 33.9%), Origanum vulgare, (thymol 0.4%; carvacrol 66.2%) and Satureja hortensis, (thymol 1.7%; carvacrol 46.6%), had apparent kinh (30 °C, PhCl) of (1.5 ± 0.3) × 104, (1.3 ± 0.1) × 104 and (1.1 ± 0.3) × 104 M−1s−1, respectively, while phenylpropanoid-rich Eugenia caryophyllus (eugenol 80.8%) and Cinnamomum zeylanicum, (eugenol 81.4%) showed apparent kinh (30 °C, PhCl) of (5.0 ± 0.1) × 103 and (4.9 ± 0.3) × 103 M−1s−1, respectively. All EOs already granted good antioxidant protection of cumene at a concentration of 1 ppm (1 mg/L), the duration being proportional to their phenolic content, which dictated their antioxidant behavior. They also afforded excellent protection of squalene after adjusting their concentration (100 mg/L) to account for the much higher oxidizability of this substrate. All investigated EOs had kinh comparable to synthetic butylated hydroxytoluene (BHT) were are eligible to replace it in the protection of food or cosmetic products.

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“…Diversos metabolitos secundários oriundos de produtos naturais são relacionados às propriedades antioxidantes, sendo os compostos fenólicos aqueles mais eficazes (Guo et al, 2020;Navajas-Porras et al, 2020). Estas substâncias têm a capacidade de inativar espécies reativas de oxigênio e nitrogênio em razão da presença de grupos -OH diretamente ligados a anéis aromáticos, que podem quelar metais pró-oxidativos, ativar enzimas antioxidantes, inibir a peroxidação lipídica e também promover reação oxidativa in vitro (Nieva-Rchevarría, Goicoechea & Guillén, 2017; Olszowy, 2019).…”

Section: Resultsunclassified

Aumento da atividade anticoagulante da varfarina e sua potencial interação com o extrato aquoso de goji berry (Lycium barbarum L.) em ratos Wistar

Oliveira

Camilo

Marques

et al. 2020

RSD

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O consumo de goji berry (Lycium barbarum L.) tem despertado interesse mundial devido suas excelentes propriedades nutricionais e funcionais, relacionada à diminuição do risco de desenvolvimento de doenças crônicas decorrentes do estresse oxidativo, o classifica como um “super alimento”. Assim, o objetivo deste estudo foi avaliar os efeitos do extrato aquoso de goji berry nos parâmetros hematológicos e bioquímicos em ratos Wistar tratados com varfarina. A concentração de fenóis totais foi determinada pelo reagente Folin-Ciocalteau, enquanto a capacidade antioxidante determinada pelo ensaio DPPH. Os animais foram distribuídos em quatro grupos experimentais: água destilada (veículo – controle negativo); alimentados diariamente com o extrato (0,18 g.Kg-1); tratados diariamente com água destilada e varfarina (0,5 mg.Kg-1 – controle positivo) e aqueles tratados concomitantemente com o extrato e varfarina, durante sete dias. Nossos resultados demonstraram elevada quantidade de polifenóis (6,19 ± 0,3 mg EAG.g-1) no extrato aquoso a 10 % (m.v-1) e sugerem considerável atividade antioxidante (IC50 1068 µg.mL-1). Não observamos diferenças significativas entre os perfis bioquímicos e hematológicos, ou sequer sinais de toxicidade do extrato quando administrado sozinho. Os dados provenientes do uso concomitante com a varfarina são impressionantes e mostram aumento significante no tempo de protombina, com a potencialidade de sangramento. Coletivamente, essas observações sugerem a propensão de uma interação clinicamente importante entre a varfarina e o Lycium barbarum L., o que compromete a segurança deste medicamento e lança luz para pesquisas futuras relacionadas a uma compreensão mais profunda dos mecanismos moleculares envolvidos.

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Synergic antioxidant activity of γ-terpinene with phenols and polyphenols enabled by hydroperoxyl radicals

Cited by 58 publications

References 40 publications

Physicochemical properties, chemical components, and antibacterial activity of Melaleuca cajuputi Powell essential oil leaves from Quang Tri Province, Vietnam

Physicochemical properties, chemical components, and antibacterial activity of Melaleuca cajuputi Powell essential oil leaves from Quang Tri Province, Vietnam

Absolute Antioxidant Activity of Five Phenol-Rich Essential Oils

Aumento da atividade anticoagulante da varfarina e sua potencial interação com o extrato aquoso de goji berry (Lycium barbarum L.) em ratos Wistar

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