“…Diameter PCL Improved hemocompatibility with large fiber diameter [ 87,101] PCL, PLGA Enhanced EC adhesion and proliferation with small fiber diameter [ 102,103] PLLA Promoted cell migration with large fiber diameter [ 104] PCL Enhanced chondrogenic differentiation of MSC with large fiber diameter [105][106][107] Stiffness PA Inhibited platelet adhesion, spreading and activation on soft substrate [ 108,109] PLL/HA Enhanced EC adhesion, migration, and proliferation on stiff substrate [ 110,111] PLCL/PLLA Inhibited SMC adhesion, induce abnormal phenotype on stiff substrate [ 112,113] PAA Favored cell migration towards soft matrices [ 114,115] PEG Enhanced MSC spreading, favored osteogenesis differentiation on stiff matrices [ 110] Roughness PLGA Inhibited thrombin formation and platelets adhesion on smooth surface [116][117][118] PHMMA Enhanced EC adhesion on rough surface with lotus leaf topography [119,120] PCL Enhanced MSC osteogenic differentiation on specific surface-rough surface [ 121] Alignment PCL, PLCL Enhanced EC oriented migration on aligned fibrous substrate [ 122,123] PLLA Promoted cell infiltration into aligned fibers [ 124] PCL, PLLA Enhanced MSC orientation and osteogenesis differentiation on aligned fibrous substrate [ 125,126] microfiber scaffold (fiber diameter ≈ 6 µm), nanofiber scaffold (fiber diameter <1 µm), outer microfiber bilayer scaffold, and inner microfiber bilayer scaffold, the microfiber scaffold group showed the thickest neotissue regeneration, a SMC layer, and best vascularization in vivo. [89] These results indicated that the surrounding tissue contributes more significantly than the circulating blood in neotissue formation, SMCs' regeneration, and vascularization in the graft wall.…”