2019
DOI: 10.1016/j.apsusc.2019.04.109
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Synergetic effect of electrospun PCL fiber size, orientation and plasma-modified surface chemistry on stem cell behavior

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Cited by 51 publications
(80 citation statements)
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“…A similar type of argon plasma treatment mediated by dielectric barrier discharge in [ 30 ] was not able to render the PCL surface completely wettable. In [ 30 ], the contact angle was reduced from the initial 75° to 52°, at an energy density of 2.5 J/cm 2 . The reason is twofold.…”
Section: Resultsmentioning
confidence: 99%
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“…A similar type of argon plasma treatment mediated by dielectric barrier discharge in [ 30 ] was not able to render the PCL surface completely wettable. In [ 30 ], the contact angle was reduced from the initial 75° to 52°, at an energy density of 2.5 J/cm 2 . The reason is twofold.…”
Section: Resultsmentioning
confidence: 99%
“…First, in our case, PCL samples were treated at a substantially higher power density of approximately 17 J/cm 2 . Second, the treatment in [ 30 ] (and similarly in [ 31 ]) was done at low pressure of 5 kPa, and special attention had been paid to samples degasifying from ambient gas residuals. In our case, the intended introduction of polar functional groups to the PCL surface relied on the dissociative interactions of excited argon species with adsorbed water and other oxygen-containing molecules.…”
Section: Resultsmentioning
confidence: 99%
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“…Diameter PCL Improved hemocompatibility with large fiber diameter [ 87,101] PCL, PLGA Enhanced EC adhesion and proliferation with small fiber diameter [ 102,103] PLLA Promoted cell migration with large fiber diameter [ 104] PCL Enhanced chondrogenic differentiation of MSC with large fiber diameter [105][106][107] Stiffness PA Inhibited platelet adhesion, spreading and activation on soft substrate [ 108,109] PLL/HA Enhanced EC adhesion, migration, and proliferation on stiff substrate [ 110,111] PLCL/PLLA Inhibited SMC adhesion, induce abnormal phenotype on stiff substrate [ 112,113] PAA Favored cell migration towards soft matrices [ 114,115] PEG Enhanced MSC spreading, favored osteogenesis differentiation on stiff matrices [ 110] Roughness PLGA Inhibited thrombin formation and platelets adhesion on smooth surface [116][117][118] PHMMA Enhanced EC adhesion on rough surface with lotus leaf topography [119,120] PCL Enhanced MSC osteogenic differentiation on specific surface-rough surface [ 121] Alignment PCL, PLCL Enhanced EC oriented migration on aligned fibrous substrate [ 122,123] PLLA Promoted cell infiltration into aligned fibers [ 124] PCL, PLLA Enhanced MSC orientation and osteogenesis differentiation on aligned fibrous substrate [ 125,126] microfiber scaffold (fiber diameter ≈ 6 µm), nanofiber scaffold (fiber diameter <1 µm), outer microfiber bilayer scaffold, and inner microfiber bilayer scaffold, the microfiber scaffold group showed the thickest neotissue regeneration, a SMC layer, and best vascularization in vivo. [89] These results indicated that the surrounding tissue contributes more significantly than the circulating blood in neotissue formation, SMCs' regeneration, and vascularization in the graft wall.…”
Section: Materials Biological Effectsmentioning
confidence: 99%