Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) Associated with Mediastinal Schwannoma

Song, Seung-Ho; Sim, Gyeong Ah; Baek, Seon Ha; Seo, Jungpil; Shim, Jung Weon; Koo, Ja Ryong

doi:10.5049/ebp.2017.15.2.42

Cited by 4 publications

(3 citation statements)

References 16 publications

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“…When these tumors compress the adjacent structures, they will cause symptoms such as chest pain, hoarseness, dyspnea, or dysphagia [5,6]. Other rare symptoms caused by mediastinal schwannomas include inappropriate secretion of antidiuretic hormone syndrome (IADH syndrome) [7], Horner syndrome [8], intrathoracic bleeding [9], and pleural effusion [10].…”

Section: Discussionmentioning

confidence: 99%

Resection of a schwannoma originating from vagus nerve in the right superior mediastinum

Zhang

Sheng

et al. 2023

J Cardiothorac Surg

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Background Schwannoma is the most common mediastinal neurogenic tumor, while schwannoma originating from mediastinal vagus nerve is rare. Case presentation This article reported one case of schwannoma originating from vagus nerve in the right superior mediastinum. The mediastinal schwannoma was completely resected through a right-sided video-assisted thoracoscopic thoracotomy. Histologic examination clarified the diagnosis as schwannoma. Conclusion Chest CT scan and MRI can be used to determine the location of mediastinal schwannoma and its relationship with adjacent tissue. Histologic examination showing distinctive feature of Antoni A areas and Antoni B areas can help clarify the diagnosis. Complete surgical resection is the first-line treatment option for mediastinal schwannomas.

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Section: Discussionmentioning

confidence: 99%

Resection of a schwannoma originating from vagus nerve in the right superior mediastinum

Zhang

Sheng

et al. 2023

J Cardiothorac Surg

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“…The incidence of SIADH following transsphenoidal surgeries ranges from 1.8% to 37%, and tolvaptan has been reported to yield significant sodium correction rates, notwithstanding adverse effects, therefore reducing the length of hospital stay [83][84][85][86][87][88]. Hyponatremia due to SIADH is also associated with schwannoma, owing to adrenal insufficiency and panhypopituitarism caused by an intra-or suprasellar mass [89]. Corpus callosum agenesis (CCA), a common midline defect associated with various neurological disorders and syndromes, may present with seizures, among other symptoms, thus necessitating the administration of antiepileptic medications, which have been associated with SIADH, as mentioned above [90].…”

Section: Postoperative Hyponatremiamentioning

confidence: 99%

A Conspectus of Euvolemic Hyponatremia, Its Various Etiologies, and Treatment Modalities: A Comprehensive Review of the Literature

Ghosal,

Qadeer,

Nekkanti

et al. 2023

Cureus

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Hyponatremia is the most prevalent electrolyte imbalance encountered among hospitalized patients, athletes, the elderly, patients with chronic ailments, postoperative patients, and a few asymptomatic individuals. Clinical manifestations of hyponatremia can be diverse, with characteristic neurological symptoms. Depending on in-depth medical history, physical examination (including volume status assessment), laboratory investigation, and drug history, patients can be classified broadly as undergoing hypervolemic, euvolemic, or hypovolemic hyponatremia. However, patients with hypervolemic hyponatremia often present with distinctive signs such as edema or ascites, and the clinical presentation of hypovolemic and euvolemic hyponatremia poses significant challenges for clinicians. The convolution in clinical manifestations of patients is due to the varied etiologies of euvolemic hyponatremia, such as syndrome of inappropriate antidiuretic hormone secretion (SIADH), adrenocortical insufficiency, hypothyroidism, psychogenic polydipsia, different classes of drugs (chemotherapeutics, antipsychotics, antidepressants), endurance exercise events, and reset osmostat syndrome (ROS). The management of hyponatremia depends on the rate of hyponatremia onset, duration, severity of symptoms, levels of serum sodium, and underlying comorbidities. Over the last decade, the clinical understanding of hyponatremia has been scattered due to the introduction of innovative laboratory markers and new drugs. This article will be a conspectus of all the recent advancements in the field of diagnosis, investigations, management, and associations of hyponatremia, along with traditional clinical practices. Subsequently, a holistic overview has been laid out for the clinicians to better understand and identify knowledge deficiencies on this topic.

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“…Patients can be asymptomatic or present with chest pain or symptoms secondary to the extrinsic compression of airways or the esophagus by a large mediastinal tumor ( 5 , 14 , 27 ). Rarely schwannoma patients present with Horner’s syndrome, pleural effusion, mediastinal hemorrhage or inappropriate secretion of antidiuretic hormone syndrome (IADH syndrome) ( 16 , 28 - 31 ). Vijendra et al .…”

Section: Benign Tumors Of Peripheral Nerve Originmentioning

confidence: 99%

Mediastinal tumors of peripheral nerve origin (so-called neurogenic tumors)

Marchevsky¹,

Balzer²

2020

Mediastinum

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The mediastinum can be the site of origin of a variety of benign and malignant tumors of peripheral nerve sheath origin. Although schwannoma is one of the most common tumors found in the posterior mediastinum, peripheral nerve sheath tumors are reported in all compartments of the mediastinum. The majority of peripheral nerve sheath tumors in the mediastinum as in other anatomic sites occur sporadically, and a subset of them, most notably neurofibromas, and to a lesser extent, schwannomas and malignant peripheral nerve sheath tumors, occur in patients with syndromes such as neurofibromatosis 1 (NF1). In this review, the characteristics of mediastinal nerve sheath tumors along with the histologic differential diagnosis are summarized. Primary emphasis is placed upon the use of morphologic criteria for establishing a definitive diagnosis with reference to photomicrographs to illustrate the classic and sometimes unusual features of this varied group of tumors. The judicious application of ancillary testing, most frequently immunohistochemistry, for separating peripheral nerve sheath tumors from each other and from their morphologic mimics is reviewed. Included in the review are the clinicopathologic features, clinical management and prognostic implications of benign and malignant mediastinal peripheral nerve sheath tumors.

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Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) Associated with Mediastinal Schwannoma

Cited by 4 publications

References 16 publications

Resection of a schwannoma originating from vagus nerve in the right superior mediastinum

Resection of a schwannoma originating from vagus nerve in the right superior mediastinum

A Conspectus of Euvolemic Hyponatremia, Its Various Etiologies, and Treatment Modalities: A Comprehensive Review of the Literature

Mediastinal tumors of peripheral nerve origin (so-called neurogenic tumors)

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