2017
DOI: 10.5935/0101-2800.20170013
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Syndrome of inappropriate antidiuretic hormone secretion induced by the phytotherapy Harpagophytum procumbers: case report

Abstract: Introdução:A síndrome da secreção inapropriada do hormônio antidiurético (SIADH) consiste na incapacidade de supressão do hormônio antidiurético (ADH), comprometendo os mecanismos de excreção da água e concentração urinária. Possui como manifestações a hiponatremia e seus sintomas, sobretudo neurológicos. Há variadas causas que desencadeiam tal distúrbio, a se destacarem: distúrbios do sistema nervoso central, neoplasias malignas e drogas, dentre outros. Relato de Caso: Paciente feminina, 65 anos, hipertensa, … Show more

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Cited by 5 publications
(3 citation statements)
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“…A variety of Devil's Claw products and dietary supplements have been commercially marketed for over 50 years and are widely used for inflammatory health conditions such as arthritis, lower back pain, rheumatism and neuralgia [20]. While clinical studies conducted over the past twenty years support the general safety of such products, infrequent gastrointestinal disturbances (diarrhea, nausea, vomiting, abdominal pain), headache and vertigo, electrolyte imbalance, hypertension, and hypersensitivity (allergic) reactions (rash, hives and face swelling) have been documented [4,[21][22][23][24][25]. Most toxicologic studies of Devil's Claw materials have used products that were not chemically defined [26][27][28] and used only male rats.…”
Section: Discussionmentioning
confidence: 99%
“…A variety of Devil's Claw products and dietary supplements have been commercially marketed for over 50 years and are widely used for inflammatory health conditions such as arthritis, lower back pain, rheumatism and neuralgia [20]. While clinical studies conducted over the past twenty years support the general safety of such products, infrequent gastrointestinal disturbances (diarrhea, nausea, vomiting, abdominal pain), headache and vertigo, electrolyte imbalance, hypertension, and hypersensitivity (allergic) reactions (rash, hives and face swelling) have been documented [4,[21][22][23][24][25]. Most toxicologic studies of Devil's Claw materials have used products that were not chemically defined [26][27][28] and used only male rats.…”
Section: Discussionmentioning
confidence: 99%
“…A case of hyponatremia in a patient with systemic hypertension has been associated with Harpagophytum (co-medications were losartan, clonidine, omeprazole, and simvastatin) [ 569 ]. Another case report suggests development of grade 2 symptomatic hypertension in a normotensive woman during self-administration of Harpagophytum [ 570 ].…”
Section: Clinical Researchmentioning
confidence: 99%
“…Якщо гіпонатріємія є стійкою, можна дати хлорид натрію у формі пероральних таблеток солі або внутрішньовенне введення фізіологічного розчину. Таблетки солі також можуть бути поєднані з діуретиками, такими, як фуросемід (по 20 мг двічі на день), оскільки це сприяє зниженню концентрації сечі та, тим самим, збільшує екскрецію води, особливо серед пацієнтів, котрі мають осмолярність сечі набагато вище, ніж сироваткова осмолярність (більше 500 мОсм/кг) [14].…”
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