Syndrome of Inappropriate Antidiuresis in Ovarian Serous Carcinoma with Neuroendocrine Differentiation

Syndrome of Inappropriate ADH Secretion (SIADH) During Chemotherapy with Carboplatin/Paclitaxel for Metastatic Fallopian Tube Cancer

“…Taskin et al (1995) described the first case of a paraneoplastic SIADH syndrome in epithelial ovarian cancer (EOC), with SIADH related symptoms being in fact its initial clinical presentation in a patient with primary high grade serous ovarian cancer. Additional analyses in this patient revealed elevated ADH serum levels as well as a focal positive ADH antibody staining ascertained by immunhistochemistry [4]. However, ADH serum levels in our patient remained within the normal limits.…”

“…Yokohama et al [3] described 2005 a similar case of SIADH during carboplatinbased therapy for recurrent serous-papillary ovarian cancer. The other two cases described SIADH as prodromal clinical manifestation of ovarian cancer either at primary diagnosis [4] or at the time of recurrence [6]. We describe the first case of a patient with high grade epithelial fallopian tube cancer and pulmonary metastases experiencing SIADH postoperatively during first line chemotherapy with carboplatin and paclitaxel.…”

“…The association of SIADH with gynecological cancer is rare and has been described in four cases of ovarian cancer since 1985 [2][3][4][5]. In two of them SIADH occurred in timely relation to chemotherapy: the first one (1985) [2] described a case of SIADH associated with cisplatinum first line chemotherapy for endometrioid ovarian cancer.…”

Immature ovarian teratoma with hyponatremia and low serum vasopressin level

“…Many cases of SIADH in cancer patients are complications of small cell lung cancer and it is a well‐known negative prognostic factor . To date, only four cases have been reported that have been complications of ovarian tumors; however, the mechanisms are not yet clear . In the present case, we experienced an immature ovarian teratoma with a hyponatremia that was resistant to medical treatment before surgery, but was improved by surgical resection of the tumor.…”

“…In many cases of ovarian tumors with hyponatremia, drug‐related SIADH has been reported to develop after chemotherapy. However, only four cases have involved complications of untreated ovarian tumors (Table ) . One of the four was a complication of serous adenocarcinoma, while the other three cases were complications of immature teratomas .…”