Syndrome in Question

Abstract

Multiple autoimmune syndrome is a rare condition, described by Humbert and Dupond in 1988. It is defined by the association of at least 3 autoimmune diseases in the same patient. Vitiligo is the most common skin condition in this syndrome. This article presents the case of a 31-year-old male with vitiligo, alopecia areata, Crohn's disease, psoriasis vulgaris and oral lichen planus. The rarity of this case is highlighted by the coexistence of four autoimmune skin diseases in association with Crohn's disease, never described in the literature.

Psoriasis, Vitiligo and Crohn's Disease Co-Existing in a Single Patient: A Variant Type of Multiple Autoimmune Syndrome?

“…Our current case had psoriasis, vitiligo and Crohn's disease. To the best of our knowledge, the co-existence of these three autoimmune diseases has previously been reported in only one patient with vitiligo, alopecia areata, Crohn's disease, psoriasis vulgaris, and oral lichen planus 12 . Although our patient lacked any recognized subtype of MAS, it is interesting to note that the three diseases are known to be interconnected in certain ways.…”