The paradoxical adverse effects of tumor necrosis factor-alpha (TNF-alpha)
antagonists have been described frequently as a result of the widespread use of these
drugs. Among the TNF-alpha blocking agents, few reports exist relating the use of
adalimumab in cutaneous sarcoidosis, although all of them show good results. More
recently, sarcoidosis onsets have been reported with various TNF-alpha inhibitors.
The current case is, to our knowledge, the first to describe the exacerbation of
cutaneous lesions of sarcoidosis treated with adalimumab.
Cutaneous involvement associated to multiple myeloma varies from 5 to 10% of cases
and is infrequently recognized. Cutaneous metastatic plasmacitomas are rare. We
present the case of a 72-year-old man with multiple myeloma in complete remission
since 2 years ago with cutaneous tumors on the trunk and face. A cutaneous biopsy was
consistent with plasmacytoma. The patient was treated with melphalan, prednisolone
and radiotherapy. Despite optimal therapeutic response of the lesions, the disease
progressed, with the appearance of new extra-cutaneous plasmocytomas. The cutaneous
metastatic plasmocytomas were the first sign of progression of the disease.
Basal cell carcinoma (BCC) is the most frequent cutaneous neoplasm of the periorbital region. After tumor excision, the function of the eyelid has to be preserved, keeping the protection of the eyeball with preservation of damp, avoiding epiphora and ectropion. The authors describe the reconstruction, in a single surgical procedure, of a full-thickness defect of the outer half of the free edge of the lower eyelid through free chondromucosal graft of the septum and Tripier flap. There are very few cases that describe the septal chondromucosal flap in eyelid reconstruction. This case also corroborates the fact that the chondromucosal graft is a valuable surgical option for reconstruction of full-thickness lower eyelid defects.
POEMS syndrome is a unique clinical entity, the diagnosis of which is made when
polyneuropathy and monoclonal gammopathy occur together, associated with other
changes such as organomegaly, endocrinopathy, skin changes and papilledema. Cutaneous
manifestations are heterogeneous, with diffuse cutaneous hyperpigmentation,
hemangiomas and hypertrichosis occurring more frequently. We report the case of a 65-
year-old female patient with this syndrome, diagnosed after 15 years of disabling
peripheral neuropathy.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.