Syndrome de détresse respiratoire aiguë post-transfusionnel : une pathologie méconnue

Moalic, V.; Vaillant, C. Le; Férec, Claude

doi:10.1016/j.patbio.2004.06.001

Cited by 9 publications

(3 citation statements)

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“…In particular, in the light of the present findings, the permission for RBC donation of individuals from the above groups should be reconsidered since it may prove ineffective from preventing TRALI in similar cases. 2 – 4 , 13 , 14 …”

Section: Discussionmentioning

confidence: 99%

“… 14 Similarly, RBC and other blood component samples from multiparous women donors should be thoroughly tested for the presence of IgG HLA-Class I and –Class II antibodies and excluded from blood donation in thalassaemia or other high-risk categories of patients. 3 , 4 , 13 , 14 …”

Section: Discussionmentioning

confidence: 99%

“… 1 , 2 TRALI has been estimated to be the third cause of transfusion-related mortality with current mortality rates ranging in the patients affected between 5 to 25%. 4 , 6 …”

Section: Introductionmentioning

confidence: 99%

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Transfusion-related acute lung injury (TRALI) in two thalassaemia patients caused by the same multiparous blood donor

Kolnagou¹,

Kontoghiorghe²,

Kontoghiorghes³

2017

Mediterr J Hematol Infect Dis

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We report two separate episodes of transfusion-related acute lung injury (TRALI) in two thalassaemia patients who received red blood cell transfusions from the same multiparous donor. Both cases had the same symptomatology and occurred within 60 minutes of transfusion. The patients presented dyspnoea, sweating, fatigue, dizziness, fever, and sense of losing consciousness. The chest x-ray showed a pulmonary oedema-like picture with both lungs filled with fluid. The patients were treated in the intensive therapy unit. They were weaned off the ventilator and discharged following hospitalization 7 and 9 days respectively. The TRALI syndrome was diagnosed to be associated with HLA-specific donor antibodies against mismatched HLA-antigens of the transfused patients. Haemovigilance improvements are essential for reducing the morbidity and mortality in transfused patients. Blood from multiparous donors should be tested for the presence of IgG HLA-Class I and –Class II antibodies before being transfused in thalassaemia and other chronically transfused patients.

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