Syndrome d’hypersensibilité médicamenteuse au ténofovir ou DRESS chez une patiente infectée par le VIH

Kombo, E.S. Bayonne; Gathse, A.

doi:10.1016/j.medmal.2013.01.008

Cited by 7 publications

(3 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A final sample of 35 cases was analyzed involving 5 antiretrovirals: Abacavir in 10 (28.6%) cases,[ 15 16 17 18 19 20 21 22 23 24 ] efavirenz in 6 (17.1%),[ 25 26 27 28 29 30 ] nevirapine in 12 (34.3%),[ 31 32 33 34 35 36 37 38 39 40 ] raltegravir in 6 (17.1%),[ 41 42 43 44 45 46 ] and tenofovir in 1 (2.9%) case. [ 47 ] Table 1 shows the characteristics of the included patients. Most cases involved middle-aged patients with a male gender preference.…”

Section: Resultsmentioning

confidence: 99%

Drug reaction with eosinophilia and systemic symptoms related to antiretroviral treatment in human immunodeficiency virus patients

Brandariz

Smithson

Antón-Vázquez

2017

Indian J Sex Transm Dis

View full text Add to dashboard Cite

Background:The drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a life-threatening condition caused by different medications. The objective of this study was to analyze DRESS cases related to antiretroviral therapy in human immunodeficiency virus (HIV) patients.Materials and Methods:Systematic review of DRESS suspected cases in HIV patients associated to antiretrovirals published between January 1998 and April 2017. The registry of the severe cutaneous adverse reactions score was used to classify each report as a “definitive,” “probable,” “possible,” or “no” DRESS case. Clinical characteristics, management, and outcomes were evaluated.Results:Thirty-five case reports were analyzed involving 5 antiretrovirals: Abacavir in 10 (28.6%) cases, efavirenz in 6 (17.1%), nevirapine in 12 (34.3%), raltegravir in 6 (17.1%), and tenofovir in 1 (2.9%). Mean age of the patients was 40 ± 13 years, 65% of which were male. A total of 57.1% reports were classified as having a “definitive-probable” DRESS case. Management was based on withdrawal of the causal antiretroviral and corticosteroids in 68.6% of the cases. None of the patients died. Treatment with nevirapine or raltegravir, the longer onset of symptoms and the presence of lymphadenopathy, eosinophilia, liver involvement, and a longer time for clinical resolution were more frequent among “definitive-probable” DRESS cases.Conclusions:A DRESS syndrome has to be suspected in HIV patients with lymphadenopathy, eosinophilia, and liver involvement developing weeks after the initiation of nevirapine or raltegravir. Suspension of the causal antiretroviral and in most cases treatment with corticosteroids allowed adequate clinical control.

show abstract

Section: Resultsmentioning

confidence: 99%

Drug reaction with eosinophilia and systemic symptoms related to antiretroviral treatment in human immunodeficiency virus patients

Brandariz

Smithson

Antón-Vázquez

2017

Indian J Sex Transm Dis

View full text Add to dashboard Cite

show abstract

“…Various medications have been implicated in triggering DRESS syndrome with phenytoin, carbamazepine, and phenobarbital being the most common 14. It has also been associated with antiretroviral therapy15; however, tenofovir-induced DRESS has been reported only once in literature 4. Our patient was started on tenofovir two months earlier, developed a skin eruption with liver failure shortly thereafter, was found to have elevated eosinophils in his blood, a skin biopsy showing spongiotic dermatitis with eosinophilia, and a complete resolution of symptoms within 10 days of discontinuation of the medication.…”

Section: Discussionmentioning

confidence: 99%

“…The incidence is uncertain but it has an estimated population risk that ranges between 1 in 1000 and 1 in 10,000 drug exposures 3. Fifty or more drugs have been implicated, but tenofovir-induced DRESS is extremely rare has only been previously reported once 4,5. Herein, we report a case of a patient who developed tenofovir-induced DRESS that manifested as liver failure, skin eruption, and Raynaud’s of the tongue.…”

Section: Introductionmentioning

confidence: 95%

<p>A Unique Case Of Tenofovir-Induced DRESS Syndrome Associated With Raynaud’s Of The Tongue</p>

Aqtash

Ajmeri

Thornhill

et al. 2019

IJGM

View full text Add to dashboard Cite

Drug reaction with eosinophilia and systemic symptoms (DRESS) is a potentially fatal severe adverse reaction to medications. Numerous drugs have been implicated, with carbamazepine and allopurinol being the most common. Tenofovir-induced DRESS is extremely rare. We report a case of a 65-year-old male patient with a diffuse exfoliative maculopapular rash across his entire body of five weeks of duration. The patient also had icteric sclera, abnormal liver enzymes and Raynaud’s of the tongue, nose and the left fifth finger. After discontinuation of tenofovir, the case resolved over a span of ten days. A high index of suspicion is crucial along with the prompt withdrawal of the offending medication for a good outcome.

show abstract

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)

et al. 2013

View full text Add to dashboard Cite

DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms), also known as hypersensitivity syndrome (HSS), is a severe and potentially life-threatening drug reaction. The worldwide rate of mortality is about 10 %, its incidence is increasing. Drugs that most frequently induce DRESS are aromatic anticonvulsive drugs (carbamazepine, lamotrigine, phenobarbital), and more recently new retroviral therapies. The pathogenesis of DRESS is not yet fully understood, but is certainly multifactorial involving a combination of immune reactions, ethnic predisposition, genetically determined enzyme deficiencies and reactivation of herpes viruses (HHV-6, HHV-7, EBV, CMV). Because of the involvement of the skin and internal organs, the clinical picture can be very variable. No specific clinical, histologic or laboratory parameter is available, so the diagnosis has to rely on the clinical appearance. The long latency period between start of drug intake and the initial manifestation of DRESS and the successive onset of skin and organ involvement complicates the early diagnosis. Although or even because DRESS represents a diagnostic challenge, detailed knowledge about this disease is of utmost importance to enable early therapeutic actions.

show abstract

Syndrome d’hypersensibilité médicamenteuse au ténofovir ou DRESS chez une patiente infectée par le VIH

Cited by 7 publications

References 6 publications

Drug reaction with eosinophilia and systemic symptoms related to antiretroviral treatment in human immunodeficiency virus patients

Drug reaction with eosinophilia and systemic symptoms related to antiretroviral treatment in human immunodeficiency virus patients

<p>A Unique Case Of Tenofovir-Induced DRESS Syndrome Associated With Raynaud’s Of The Tongue</p>

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)

Contact Info

Product

Resources

About