Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)

Ständer, Sonja; Metze, Dieter; Luger, Thomas A.; Schwarz, Thomas

doi:10.1007/s00105-013-2615-0

Cited by 7 publications

(4 citation statements)

References 40 publications

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“…Aromatic anticonvulsive drugs, such as carbamazepine, lamotrigine, and phenobarbital, are the most common medicines known to induce DRESS and TEN [17,21]. In the present study, five cases of TEN and one patient with DRESS were diagnosed.…”

Section: Discussionmentioning

confidence: 98%

Incidence of adverse cutaneous drug reactions in 22,866 Chinese inpatients: a prospective study

et al. 2015

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Cutaneous adverse drug reactions (ADRs) are common. However, no prospective study assessing cutaneous ADRs is available for Chinese populations. This study aimed to assess the incidence, manifestations, causative drugs, and other factors related to cutaneous ADRs. A total of 22,866 inpatients were surveyed prospectively from January to April 2012 at the Peking Union Medical College Hospital. Only cutaneous ADRs induced by systemic drugs were considered. Fifty cases were confirmed as cutaneous ADRs, for an estimated incidence of 2.2 per 1000 during this period (95 % confidence interval 1.6-2.8). Cases of cutaneous ADRs comprised 69 % females, while 63 % of all inpatients were female (χ (2) = 0.641, P = 0.427). The department of infectious diseases was the most frequently involved department. Morbilliform exanthema (40 %) was the most frequent cutaneous ADR, followed by urticaria (23.1 %). Anti-infection drugs (36.9 %) caused most cases of cutaneous ADRs, followed by iodinated contrast media (ICM, 18.5 %) and non-steroidal anti-inflammatory drugs (NSAIDs, 18.5 %). The most frequently associated disorders were cancer (24 %), infection (22 %), cardiovascular and cerebrovascular diseases (20 %), and autoimmune diseases (18 %). In this first prospective study assessing the incidence of cutaneous ADRs in China, anti-infection drugs were the most commonly involved drugs, followed by ICM and NSAIDs. No evidence of increased cutaneous ADR incidence in AIDS or SLE patients was observed. Our findings indicate that cancer and its treatments were often related to cutaneous ADRs in China.

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Section: Discussionmentioning

confidence: 98%

Incidence of adverse cutaneous drug reactions in 22,866 Chinese inpatients: a prospective study

et al. 2015

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“…Antiepileptics such as carbamazepine and lamotrigine, sulfonamides, allopurinol, terbinafi ne, vancomycin [ 58 ], and more recently new retroviral drugs [ 56 ] are among the main inducers of DHS/DRESS. The reaction has a long latency period up to 8 weeks after starting the responsible drug [ 4 ].…”

Section: Drug Hypersensitivity Syndrome/drug Rash With Eosinophilia Amentioning

confidence: 99%

“…DHS/DRESS is an uncommon but severe, idiosyncratic drug reaction with a significant risk of morbidity and mortality [ 56 ]. It is defi ned by generalized, long-lasting maculopapular ( Fig.…”

Section: Drug Hypersensitivity Syndrome/drug Rash With Eosinophilia Amentioning

confidence: 99%

General Aspects of Adverse Cutaneous Drug Reactions

Özkaya

Yazganoğlu

2014

Adverse Cutaneous Drug Reactions to Cardiovascular Drugs

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“…Moreover, the timing of testing following an ADR affects the LTT outcome, with results showing disease-specific differences. Thus, compared with other ADR, detection of the causative drug by LTT in case of DRESS is substantially delayed (weeks to months) following the clinical reaction [ 40 , 41 ].…”

Section: T-lymphocyte Testsmentioning

confidence: 99%

Cellular in vitro diagnosis of adverse drug reactions

Möbs

Pfützner

2014

Allergo J Int

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Adverse drug reactions can manifest clinically in a variety of ways. Whilst the majority can be explained by dose-dependent side effects, there is group of unpredictable immunological or non-immunological intolerances that represent a particular diagnostic challenge. Skin tests are frequently negative, whilst challenge tests are time-consuming and often hazardous. Against this backdrop, cellular in vitro tests play a particularly important role in the identification of the causative drug. Whilst basophil tests can be used in the case of immunoglobulin E (IgE)- as well as non-IgE-mediated hypersensitivity reactions, T-cellular test methods assist in the diagnosis of drug eruptions. The reliability of individual tests can be affected by a variety of parameters, such as the pathomechanism underlying the drug reaction, the causative medication, or the point in time of testing. Not only is a sound knowledge of the basic principles of the individual assays an essential prerequisite for correctly indicating and interpreting this test method, but also an awareness of these additional factors.

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Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)

Cited by 7 publications

References 40 publications

Incidence of adverse cutaneous drug reactions in 22,866 Chinese inpatients: a prospective study

Incidence of adverse cutaneous drug reactions in 22,866 Chinese inpatients: a prospective study

General Aspects of Adverse Cutaneous Drug Reactions

Cellular in vitro diagnosis of adverse drug reactions

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