Synchrotron X-Ray Synthesized Gold Nanoparticles for Tumor Therapy

Chien, Chia‐Chi; Wang, C. H.; Hua, Tzu-En; Tseng, P. Y.; Yang, Tsung-Yeh; Hwu, Y.; Chen, Y. J.; Chung, Kwok‐Hung; Je, J. H.; Margaritondo, G.

doi:10.1063/1.2436445

Cited by 14 publications

(10 citation statements)

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“…Furthermore, GNPs can improve the contrast of the X-ray unit mammography through imaging the gold distribution in the tumor (Figure 13), which could be used to diagnose tumor earlier. Subsequently, similar results were reported by Chien et al, who used 20 nm gold nanoparticles as radiosensitizers for X-ray radiotherapy [151]. In Chang et al 's in vivo research, GNPs accumulation was observed inside cancer cells, which induced efficiency enhancement of ionizing radiation, cancer cell apoptosis, tumor growth inhibition, and a high chance survival of tumor-bearing mice [152].…”

Section: Gold Nanoparticle-aided Radiotherapysupporting

confidence: 56%

Gold Nanoparticle Mediated Phototherapy for Cancer

Yao

Zhang

Wang

et al. 2016

Journal of Nanomaterials

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Gold nanoparticles exhibit very unique physiochemical and optical properties, which now are extensively studied in range of medical diagnostic and therapeutic applications. In particular, gold nanoparticles show promise in the advancement of cancer treatments. This review will provide insights into the four different cancer treatments such as photothermal therapy, gold nanoparticle-aided photodynamic therapy, gold nanoparticle-aided radiation therapy, and their use as drug carrier. We also discuss the mechanism of every method and the adverse effects and its limitations.

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Section: Gold Nanoparticle-aided Radiotherapysupporting

confidence: 56%

Gold Nanoparticle Mediated Phototherapy for Cancer

Yao

Zhang

Wang

et al. 2016

Journal of Nanomaterials

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“…The results indicated a DEF of 1.01 to 2.95 (1.44 ± 0.43) depending on the NPs type, NPs concentration, NPs size, cell line, radiation energy, and delivery condition. Table S1 30 - 106 (See online Supplementary file 1 ) summarizes the main results of the involved studies such as the NPs’ size, NPs’ concentration, cell line types, and radiation energy.The sensitizing characteristics of NPs have been established on various cell lines. To better compare the effect of different NPs concentrations, the reported concentrations in the articles were converted to the same unit (mM).…”

Section: Resultsmentioning

confidence: 99%

Main Approaches to Enhance Radiosensitization in Cancer Cells by Nanoparticles: A Systematic Review

et al. 2020

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In recent years, high atomic number nanoparticles (NPs) have emerged as promising radio-enhancer agents for cancer radiation therapy due to their unique properties. Multi-disciplinary studies have demonstrated the potential of NPs-based radio-sensitizers to improve cancer therapy and tumor control at cellular and molecular levels. However, studies have shown that the dose enhancement effect of the NPs depends on the beam energy, NPs type, NPs size, NPs concentration, cell lines, and NPs delivery system. It has been believed that radiation dose enhancement of NPs is due to the three main mechanisms, but the results of some simulation studies failed to comply well with the experimental findings. Thus, this study aimed to quantitatively evaluate the physical, chemical, and biological factors of the NPs. An organized search of PubMed/Medline, Embase, ProQuest, Scopus, Cochrane and Google Scholar was performed. In total, 77 articles were thoroughly reviewed and analyzed. The studies investigated 44 different cell lines through 70 in-vitro and 4 in-vivo studies. A total of 32 different types of single or core-shell NPs in different sizes and concentrations have been used in the studies.

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“…In the past decade, while a substantial number of studies have investigated radiosensitization by gold nanoparticles (GNPs) in vitro, little has been published on their radiosensitizing properties in vivo. [1][2][3][4][5][6][7][8][9][10] Tumor growth retardation or improvements in animal survival were observed only at very high doses of GNPs (∼2 g/kg) administered intravenously (IV) prior to tumor irradiation. 5,8 With much lower doses, ie, 13.5 mg of GNPs injected IV, no tumor growth retardation was measured in mice bearing murine mammary carcinoma.…”

Section: Introductionmentioning

confidence: 99%

Increased radiosensitivity of colorectal tumors with intra-tumoral injection of low dose of gold nanoparticles

Shi¹,

Paquette²,

Thippayamontri³

et al. 2016

IJN

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The potential of gold nanoparticles (GNPs) as radiosensitizers for the treatment of malignant tumors has been limited by the large quantities of GNPs that must be administered and the requirement for low-energy X-ray irradiation to optimize radiosensitization. In this study, we enhance the radiosensitivity of HCT116 human colorectal cells with tiopronin-coated GNPs (Tio-GNPs) combined with a low-energy X-ray (26 keV effective energy) source, similar to the Papillon 50 clinical irradiator used for topical irradiation of rectal tumors. Sensitizer enhancement ratios of 1.48 and 1.69 were measured in vitro, when the HCT116 cells were incubated with 0.1 mg/mL and 0.25 mg/mL of Tio-GNPs, respectively. In nude mice bearing the HCT116 tumor, intra-tumoral (IT) injection of Tio-GNPs allowed a 94 times higher quantity of Tio-GNPs to accumulate than was possible by intravenous injection and facilitated a significant tumor response. The time following irradiation, for tumors growing to four times their initial tumor volume (4Td) was 54 days for the IT injection of 366.3 μg of Tio-GNPs plus 10 Gy, compared to 37 days with radiation alone ( P =0.0018). Conversely, no significant improvement was obtained when GNPs were injected intravenously before tumor irradiation ( P =0.6547). In conclusion, IT injection of Tio-GNPs combined with low-energy X-rays can significantly reduce the growth of colorectal tumors.

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Synchrotron X-Ray Synthesized Gold Nanoparticles for Tumor Therapy

Cited by 14 publications

References 0 publications

Gold Nanoparticle Mediated Phototherapy for Cancer

Gold Nanoparticle Mediated Phototherapy for Cancer

Main Approaches to Enhance Radiosensitization in Cancer Cells by Nanoparticles: A Systematic Review

Increased radiosensitivity of colorectal tumors with intra-tumoral injection of low dose of gold nanoparticles

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