Synchronous primary carcinoid tumor and primary adenocarcinoma arising within mature cystic teratoma of horseshoe kidney: a unique case report and review of the literature

Armah, Henry B.; Parwani, Anil V.; Perepletchikov, Aleksandr

doi:10.1186/1746-1596-4-17

Cited by 29 publications

(21 citation statements)

References 45 publications

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“…In this case the tumor presented also a low grade of malignancy and differentiation as adenocarcinoma as in our case [23]. Primary renal carcinoid tumors are morphologically and histologically similar to those in other sited.…”

Section: Discussionsupporting

confidence: 70%

Incidental intraoperative discovery of a pancreatic neuroendocrine tumor associated with chronic pancreatitis

et al. 2012

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Pancreatic neuroendocrine tumors are a rare entity with an incidence between 2 per million to 5 per 100 000. Association with pancreatitis (acute or chronic) is rare and is considered to be determined by the tumoral obstruction of pancreatic ducts, but sometimes occurs without any apparent relationship between them. Non-functional neuroendocrine pancreatic tumors are usually diagnosed when either very large or metastatic. Small ones are occasionally diagnosed when imagery is performed for other diagnostic reasons. Intraoperative discovery is even rarer and poses problems of differential diagnosis with other pancreatic tumors. Association with chronic pancreatitis is rare and usually due to pancreatic duct obstruction by the tumor. We describe the case of a patient with a small non-functioning neuroendocrine tumor in the pancreatic tail accidentally discovered during surgery for delayed traumatic splenic rupture associated with chronic alcoholic pancreatitis. The tumor of 1.5cm size was well differentiated and confined to the pancreas, and was resected by a distal splenopancreatectomy.ConclusionsSurgeons should be well aware of the rare possibility of a non-functional neuroendocrine tumor in the pancreas, associated with chronic pancreatitis, surgical resection being the optimal treatment for cure. Histopathology is of utmost importance to establish the correct diagnosis, grade of differentiation, malignancy and prognosis.Virtual slidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2114470176676003.

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Section: Discussionsupporting

confidence: 70%

Incidental intraoperative discovery of a pancreatic neuroendocrine tumor associated with chronic pancreatitis

et al. 2012

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“…The majority of reports of somatictype malignancy in teratomas has described a single histological type of malignancy [4,7]. However, Armah et al [8] described a renal teratoma similar to our case, where coexisting adenocarcinoma and carcinoid tumor were seen. While sarcomas and carcinomas have been described in association with mediastinal teratomas, neuroendocrine neoplasms appear to be especially rare, with only about 6 cases reported [7,9,10].…”

Section: Discussioncontrasting

confidence: 45%

Mediastinal Teratoma with Coexisting Adenocarcinoma and Carcinoid Tumor (Somatic-Type Malignancy): A Case Report with a Review of the Literature

et al. 2015

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Germ cell tumors constitute 10% to 15% of anterior mediastinal neoplasms. Of these, mature teratoma is the most common. Somatic malignant transformation in mature teratoma is a very rare phenomenon. In the anterior mediastinum, few cases of malignant transformation in the form of carcinoma, sarcoma, or neuroendocrine tumors have been described. We present the case of a mature mediastinal teratoma in a 24-year-old female, diagnosed on computed tomography, where both carcinoid tumor and adenocarcinoma were seen. To the best of our knowledge, this is the first report of such a case. Malignant transformation in a mature teratoma confers a significantly worse prognosis and is difficult to diagnose only on clinical and radiological evaluation. As these lesions are so rare, the treatment options for these lesions are also not clearly defined. Extensive sampling and careful microscopic examination are needed when teratomas are submitted for pathological evaluation.

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“…Renal carcinoid tumors, similar to carcinoid tumors in other locations, are derived from neuroendocrine cells. Unlike carcinoid tumors arising in the gastrointestinal tract and lung, a definitive cell of origin within the renal parenchyma has not been identified [6][7][8]. Proposed theories for the origin of primary renal carcinoid tumors include derivation from neural crest cells entrapped within the metanephros during embryogenesis [9], neuroendocrine differentiation of a primitive totipotential cell [10,11], and hyperplasia of preexisting neuroendocrine cells within metaplastic or teratomatous epithelium [9,[11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Primary renal carcinoid tumors: clinicopathologic features of 9 cases with emphasis on novel immunohistochemical findings

et al. 2011

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Synchronous primary carcinoid tumor and primary adenocarcinoma arising within mature cystic teratoma of horseshoe kidney: a unique case report and review of the literature

Cited by 29 publications

References 45 publications

Incidental intraoperative discovery of a pancreatic neuroendocrine tumor associated with chronic pancreatitis

Incidental intraoperative discovery of a pancreatic neuroendocrine tumor associated with chronic pancreatitis

Mediastinal Teratoma with Coexisting Adenocarcinoma and Carcinoid Tumor (Somatic-Type Malignancy): A Case Report with a Review of the Literature

Primary renal carcinoid tumors: clinicopathologic features of 9 cases with emphasis on novel immunohistochemical findings

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