Synchronous occurrence of gastrointestinal stromal tumors and other primary gastrointestinal neoplasms

Wroński, Marek; Ziarkiewicz‐Wróblewska, Bogna; Górnicka, Barbara; Cebulski, Włodzimierz; Słodkowski, Maciej; Wasiutyński, Aleksander; Krasnodębski, Ireneusz W.

doi:10.3748/wjg.v12.i33.5360

Cited by 78 publications

(75 citation statements)

References 8 publications

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“…Gastrointestinal tract carcinomas are most frequently associated with GIST [9,10] . The presence of hepatic nodules in patients with a GIST must be carefully evaluated using appropriate immunohistochemical marker panel in order to distinguish metastatic GIST from other histogenetically distinct lesions (PEComa in the current case).…”

Section: Discussionmentioning

confidence: 99%

Perivascular epithelioid cell tumor of the liver coexisting with a gastrointestinal stromal tumor

Paiva

Neto²,

Agaimy³

et al. 2008

WJG

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Approximately 10% of patients with gastrointestinal stromal tumors (GIST) develop other neoplasms, either synchronously or metachronously. In this report we describe coexistence of a gastrointestinal stromal tumor and a hepatic perivascular epithelioid cell tumor (PEComa) in a 51-year-old woman with no evidence of tuberous sclerosis. A subcapsular hepatic nodule (0.8 cm in diameter) was found during surgery for symptomatic gastric neoplasm (15 cm in diameter) arising from the lesser curvature. Both tumors revealed histomorphological and immunohistochemical features confirming a diagnosis of a small incidental hepatic PEComa and a high risky extramural gastric GIST, respectively. The patient remained disease-free 25 mo after surgery with no evidence of tumor recurrence or new neoplasms. To our knowledge, this is the first report of PEComa in a patient with GIST. Hepatic lesions detected synchronously or metachronously in patients with GISTs may represent histogenetically distinct lesions and should be sampled to confirm or exclude metastatic GISTs.

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Section: Discussionmentioning

confidence: 99%

Perivascular epithelioid cell tumor of the liver coexisting with a gastrointestinal stromal tumor

Paiva

Neto²,

Agaimy³

et al. 2008

WJG

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“…This may be due to the fact that most stromal tumours originate from the stomach. Some researchers have suggested that this coincidence is probably linked to Helicobacter pylori infection [3,16]. Wronski et al reported that only 4 of 28 GIST patients had an accompanying solid tumour and that, in all of these cases, the stromal tumour was of stomach origin.…”

Section: Discussionmentioning

confidence: 99%

“…The stomach is the primary location in approximately 60-70% of cases, followed by the small intestine in 20-30% of cases. Gastrointestinal stromal tumours located in the small intestine are more aggressive than other types [1][2][3]. Although nausea, emesis, abdominal pain, GIS haemorrhage, and non-specific symptoms associated with metastatic disease are common, asymptomatic cases are not uncommon [1].…”

Section: Introductionmentioning

confidence: 99%

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Small intestine-derived gastrointestinal stromal tumour diagnosed synchronously with colon adenocarcinoma: a and review of the literature

Tanrıverdi¹,

Meydan²,

Barutça³

et al. 2011

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Gastrointestinal stromal tumours (GISTs) account for 0.1-3% of all gastrointestinal cancers. Although nausea, emesis, abdominal pain, GIS haemorrhage, and non-specific symptoms associated with metastatic disease are common, asymptomatic cases are not rare. They are located in the stomach in approximately 60-70% of cases, and in the small intestine in 20-30% of cases. Gastrointestinal stromal tumours can be seen synchronously or metachronously with other epithelial cancers. The co-occurrence of colon adenocarcinomas and GISTs in the small intestine is not common. The genetic pathways in the tumourigenesis of two different neoplasms (GIST and colorectal adenocarcinoma) being different was suggested as a probable cause; however; although the number of cases is limited, some researchers have reported that they could not rule out the possibility that this association is not coincidental. Herein we present a patient who was concomitantly diagnosed with a GIST as a result of an ileal lesion biopsy performed during surgery for colon adenocarcinoma.

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“…Su incidencia no está claramente definida, sin embargo parece ser tan alta como 14%. Los segundos tumores primarios más frecuentes en pacientes portadores de GIST son carcinoma gástrico, carcinoma de colon y linfoma gástri-co 30 .…”

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Tumores del estroma gastrointestinal (GIST), un particular tipo de neoplasia

2008

Rev. méd. Chile

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Gastrointestinal stromal tumors (GIS) are a heterogeneous group of tumors that express CD (Rev Méd Chile 2008; 136: 921-9L as primeras descripciones de tumores mesenquimáticos del tracto gastrointestinal datan de la década del 40 1 . Durante años fueron clasificados como tumores derivados de células musculares lisas basados en el parecido histológico con estas células, así fueron llamados leiomiomas bizarros, leiomiomas celulares y leiomiosarcomas 2 .Con el advenimiento de la microscopia electrónica se demostró que sólo algunos de estos tumores mostraban evidencias ultraestructurales de presentar diferenciación muscular lisa. La caracterización inmunohistoquímica ha permitido conocer los distintos tipos de diferenciación que presentan estos tumores. En 1984, Herrera et al 3 describieron una diferenciación neuronal autonó-mica en algunos subtipos de este tumor que desde 1983, gracias al trabajo de Manzur y Clark 4 , se habían denominado genéricamente como "tumores estromales". Pese a los avances, aun en la década de los 80 persistían las dudas dado que estos tumores poseen diferenciación miogénica, neural, pero también pueden presentar diferenciación mixta o sencillamente no presentar diferenciación específica. Otro hito en la historia de esta enfermedad lo marcó Hirota et al. que en 1998 descubre mutaciones funcionantes en el protooncogén c-kit de los GIST, lo que permitió a la larga una clasificación adecuada de los tumores, así como el desarrollo de una novedosa terapia molecular dirigida contra la tirosina kinasa 5 .Se ha sugerido que los GIST se originan de las células intersticiales de Cajal o desde células precursoras primitivas que se diferencian hacia

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Synchronous occurrence of gastrointestinal stromal tumors and other primary gastrointestinal neoplasms

Abstract: The synchronous occurrence of GISTs and other gastrointestinal malignancies is more common than it has been considered. The development of gastrointestinal stromal tumors and other neoplasms may involve the same carcinogenic agents.

Cited by 78 publications

References 8 publications

Perivascular epithelioid cell tumor of the liver coexisting with a gastrointestinal stromal tumor

Perivascular epithelioid cell tumor of the liver coexisting with a gastrointestinal stromal tumor

Small intestine-derived gastrointestinal stromal tumour diagnosed synchronously with colon adenocarcinoma: a and review of the literature

Tumores del estroma gastrointestinal (GIST), un particular tipo de neoplasia

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