Synchronous multifocal HPV-related neoplasm involving both the genital tract and the head-and-neck area: A case report of Fanconi anemia

Han, Tae-Jin; Lee, Chang-Hun; Yoo, Chong-Woo; Shin, Hyung Shik; Park, Hyunjin; Cho, Kwan Ho; Park, Joo-Yong; Choi, S. W.; Kim, Joo-Young

doi:10.1016/j.radonc.2009.03.009

Cited by 16 publications

(10 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…in their control group of sporadic SCCs [34] is similar to what has been reported by others in independent studies [19,20]. In addition, other authors have also reported high percentages of HPV infection in their FA patients [15,23]. Our own findings revealed WV infection in only one out of 30 sporadic HNSCC cell lines, whereas analysis of 123 tumor specimens detected HPV infection in 37 cases (30%) [4,24].…”

Section: Hpv/p53supporting

confidence: 90%

Squamous Cell Carcinomas of the Head and Neck in Fanconi Anemia: Risk, Prevention, Therapy, and the Need for Guidelines

et al. 2012

View full text Add to dashboard Cite

Fanconi anemia (FA) is a rare recessive DNA repair disorder that is clinically characterized by congenital malformations, progressive bone marrow failure, and increased incidence of malignancies, especially acute myeloid leukemia and squamous cell carcinomas of the head and neck (HNSCCs) and the anogenital regions. On a cellular level, typical features of the disorder are a high degree of genomic instability and an increased sensitivity to bi-functionally alkylating agents. So far, germ-line defects in 15 different FA genes have been identified. Some of these FA genes are also established as tumor susceptibility genes for familiar cancers. In recent years, the prevention and therapy of HNSCCs in FA patients has become more important as the percentage of patients surviving into adulthood is rising. HNSCCs appear in very young FA patients without common risk factors. Since cisplatin-based chemotherapy in combination with radiotherapy, essential parts of the standard treatment approach for sporadic HNSCCs, cannot be used in FA patients due to therapy-associated toxicities and mortalities even with reduced dosing, surgery is the most important treatment option for HNSCCs, in FA patients and requires an early and efficient detection of malignant lesions. So far, no uniform treatment protocol for the management of HNSCCs in FA patients exists. Therefore, we propose that the information on affected FA patients should be collected world-wide, practical therapeutic guidelines developed and national treatment centers established.

show abstract

Section: Hpv/p53supporting

confidence: 90%

Squamous Cell Carcinomas of the Head and Neck in Fanconi Anemia: Risk, Prevention, Therapy, and the Need for Guidelines

et al. 2012

View full text Add to dashboard Cite

show abstract

“…The rate of synchronous and metachronous lesions in HPV-positive SCCHN is, at present, largely unknown. Some case reports suggest increased susceptibility of patients with HPV+ tumours to synchronous tumours [11, 12]. Other studies suggest, however, lower incidence of metachronous tumours in HPV+ cases [13].…”

Section: Discussionmentioning

confidence: 99%

Impact of HPV infection on the clinical outcome of p-CAIR trial in head and neck cancer

Śnietura

Pigłowski

Jaworska

et al. 2010

Eur Arch Otorhinolaryngol

View full text Add to dashboard Cite

The purpose of the study was to analyse the influence of HPV infection on the outcome of a randomized clinical trial of conventional (CF) versus 7-days-a-week postoperative radiotherapy (p-CAIR) for squamous cell cancer of the head and neck (SCCHN). Between 2001 and 2004, 279 patients with high-risk SCC of the larynx or cancer of the oral cavity/oropharynx were randomized to receive 63 Gy in fractions of 1.8 Gy given 5 days a week or 7 days a week (Radiother Oncol 87:155–163, 2008). The presence of HPV DNA in 131 archival paraffin blocks was assessed with multiplex quantitative real-time PCR using five consensus primers for the conservative L1 region and molecular beacon probes targeting 14 high-risk HPV subtypes. Following the RT-PCR procedure, we could determine the presence and type of HPV16, HPV18 and the other 12 less frequent oncogenic subtypes. Out of 131 samples, 9 were positive for HPV infection (6.9%), all of them with HPV16 subtype. None of the 65 laryngeal tumours was HPV positive. The 5-year LRC in HPV-positive patients was 100%, compared to 58% in the HPV-negative group (p = 0.02, log-rank test). Amongst 122 patients with HPV-negative tumours, 5-year LRC was 50.3% in p-CF versus 65.2 in p-CAIR (p = 0.37). HPV infection was associated with low expression of EGFR and cyclin D. This study demonstrates a favourable outcome for HPV-positive patients with SCCHN treated with postoperative radiotherapy. While considering the small number of HPV+ tumours, the data set can be considered as hypothesis generating only, the outcome raises new questions on the necessity of aggressive postoperative treatment in HPV+ patients.

show abstract

“…It has recently been described that FA patients have increased susceptibility to HPV‐associated cancer, since they are carriers of deficiency in the DNA damage response pathway which normally attenuates the oncogenic potential of HPV16 E7 (Park et al , 2010). Frequency of HPV infection in FA with oral neoplasia has been reported (Kutler et al , 2003c; Van Zeeburg et al , 2008; Han et al , 2009), but no information is currently available for FA patients without clinically detectable oral lesions. The aim of this study was to investigate the prevalence of oral HPV infection in FA patients free of oral malignant lesions.…”

Section: Introductionmentioning

confidence: 99%

High prevalence of oral human papillomavirus infection in Fanconi’s anemia patients

et al. 2011

View full text Add to dashboard Cite

show abstract

Synchronous multifocal HPV-related neoplasm involving both the genital tract and the head-and-neck area: A case report of Fanconi anemia

Cited by 16 publications

References 20 publications

Squamous Cell Carcinomas of the Head and Neck in Fanconi Anemia: Risk, Prevention, Therapy, and the Need for Guidelines

Squamous Cell Carcinomas of the Head and Neck in Fanconi Anemia: Risk, Prevention, Therapy, and the Need for Guidelines

Impact of HPV infection on the clinical outcome of p-CAIR trial in head and neck cancer

High prevalence of oral human papillomavirus infection in Fanconi’s anemia patients

Contact Info

Product

Resources

About