Synchronous multicentric giant cell tumour: a case report with review of literature

Sanghvi, Vikram; Lala, Murad; Desai, S.C.; Chaturvedi, P; Rodrigues, Gabriel

doi:10.1053/ejso.1999.0723

Cited by 14 publications

(19 citation statements)

References 9 publications

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“…Multicentric GCTs are extremely rare and represent less than 1% of GCTs [32]. Fewer than 60 cases have been reported in the literature [2,3,7,8,9,10,11,12,13,14,15,16,17,19,20,21,22,23,24,25,26,27,29,30,31,33,35,36]. Therefore, the pathogenesis of multiple benign lesions is still a matter of debate [22].…”

Section: Introductionmentioning

confidence: 99%

Metachronous multicentric giant-cell tumor of the bone in the lower limb. Case report and Ki-67 immunohistochemistry study

et al. 2003

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Multicentric giant-cell tumors of the bone (GCTs) are rare. Little is known about the mechanisms by which these tumors spread and how 1% of GCT turn out to be multicentric. We report the case of a 19-year-old woman with metachronous multiple and recurrent GCTs that were unusual in their pattern of progression along the right lower limb over a 23-year period. Histology showed no evidence of malignant transformation. The treatment was repeated curettage and packing with cement. This did not permit a wide surgical margin, but avoided amputation and preserved full limb function. We tested the proliferation index marker Ki-67 in the tumor specimens. Ki-67 expression was limited to the mononuclear cell component of the tumors. The proliferation index was similar in each new tumor and higher in recurrences for each location. In this case, proliferation was initially low in the new tumor location, despite the time difference and independent from the initial clone evolution. Proliferation index increased in recurrent GCTs after marginal margin resection.

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Section: Introductionmentioning

confidence: 99%

Metachronous multicentric giant-cell tumor of the bone in the lower limb. Case report and Ki-67 immunohistochemistry study

et al. 2003

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“…These tumours are usually mono-ostotic, but may, at times, present in a polyostotic (multicentric) form, which is usually of a high grade [11]. Our patient had no evidence of a multicentric lesion on examination.…”

Section: Discussionmentioning

confidence: 56%

Giant cell tumour (osteoclastoma) of the zygoma: An extremely unusual neoplasm

Sethi

Passey

Mrig

et al. 2006

Acta Oto-Laryngologica

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“…[6] Giant cell tumors are solitary lesions; less than 1% is multicentric. [8,9,10] Multicentric Giant cell tumor (MCGCT) is more aggressive and has propensity for small bones of hand and feet. Patients with Multicentric Giant cell tumor tend to be younger [11] as in our case.…”

Section: Discussionmentioning

confidence: 99%

Multicentric Giant Cell Tumor of Ipsilateral Acetabulum and Femoral Head With Pathological Fracture of Femoral Neck: A Case Report

Jain¹,

Shanmugam²

2015

jemds

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Synchronous multicentric giant cell tumour: a case report with review of literature

Cited by 14 publications

References 9 publications

Metachronous multicentric giant-cell tumor of the bone in the lower limb. Case report and Ki-67 immunohistochemistry study

Metachronous multicentric giant-cell tumor of the bone in the lower limb. Case report and Ki-67 immunohistochemistry study

Giant cell tumour (osteoclastoma) of the zygoma: An extremely unusual neoplasm

Multicentric Giant Cell Tumor of Ipsilateral Acetabulum and Femoral Head With Pathological Fracture of Femoral Neck: A Case Report

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