Giant cell tumour (osteoclastoma) of the zygoma: An extremely unusual neoplasm

Sethi, Ashwani; Passey, Jigyasa; Mrig, Sumit; Sareen, Devendra; Sharma, Prashant

doi:10.1080/00016480500388976

Cited by 11 publications

(7 citation statements)

References 12 publications

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“…The traditional treatment of choice of GCT is surgical excision. Treatment of GCT should be directed towards functional integrity while carefully removing the lesion.…”

Section: Discussionmentioning

confidence: 99%

Multicentric giant cell tumour of the mandible: a clinical rarity

2018

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Giant cell tumours of bone (GCT) are benign, locally aggressive tumours affecting the epiphyseal regions of long bones in young adults. These nonodontogenic tumours rarely present in the oral cavity, either peripherally in soft tissues (gingiva) or centrally (in bone). GCT account for <7% of all benign jaw lesions and may present as aggressive or non-aggressive clinical forms. Histologically, these lesions are usually composed of mononuclear stromal cells and characteristic multinucleated giant cells that exhibit osteoclastic activity. Multicentricity of GCT of bone is an extreme rarity accounting for <1% of these tumours. The biological behaviour and the clinical presentation (e.g. localisation, age, and gender distribution) of multicentric GCT are different from solitary lesions. As other primary bone lesions may also have a polyostotic presentation, the precise diagnosis relies on correlation of clinical and radiographic findings with confirmation of the diagnosis by histopathologic examination. We encountered one such interesting case in a 12-year-old boy, who presented with pedunculated fibrous growth arising from the gingiva in the left mandibular posterior region along with extensive osteolytic lesions of ramus of mandible bilaterally. The workup and management of the case is hereby presented along with relevant review of literature. Clinical relevanceMulticentric osteolytic lesions with similar presentation may have varied aetiology and management. The case presented here had a unique presentation and posed a diagnostic dilemma. Precise differential diagnosis with accurate workup may aid the clinician to arrive at a correct definitive diagnosis in such cases, thus enabling prompt management of the case.

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“…The traditional treatment of choice of GCT is surgical excision. Treatment of GCT should be directed towards functional integrity while carefully removing the lesion.…”

Section: Discussionmentioning

confidence: 99%

Multicentric giant cell tumour of the mandible: a clinical rarity

2018

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“…GCT is a true neoplastic process originating from the undifferentiated mesenchymal cells of the bone marrow (10). It is generally considered as benign (6) but severe bony destruction may result occasionally depending on the location and clinical presentation of the tumor, making tumor management very challenging (9).…”

Section: Discussionmentioning

confidence: 99%

“…The treatment of choice of GCT is surgical excision (10). Regardless of the site of presentation, partial resection or curretage results in a recurrence rate of up to 70%, whereas recurrence after wide resection is about 7% (21).…”

Section: Discussionmentioning

confidence: 99%

“…Radiotherapy is generally avoided and is reserved for GCTs that are considered inoperable, due to the risk of sarcomatous transformation (9), although some authors have advocated the use of radiotherapy in the management of GCT. Other treatment modalities including cryotherapy, chemotherapy, and curretage with adjuvant agents have been tried, but have yielded less effective results (10). GCTs generally recur within the first 3 years if recurrence occurs.…”

Section: Discussionmentioning

confidence: 99%

“…GCTs arising in the head and neck region constitute approximately 2% of all GCTs, with the majority occurring in the sphenoid, ethmoid, or temporal bones (4, 5). To date, only a few reports of GCT arising from the craniofacial skeleton have been published, including from the parieto-occipital bones (6, 7), maxilla (8, 9), zygomatic bone (10, 11), and laryngeal cartilages (12). Only two studies have addressed treatment of the mandible giant cell tumors, especially with skull base extension (13, 14).…”

Section: Introductionmentioning

confidence: 99%

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Giant Cell Tumor of the Mandible

Park

Chung

Lim

et al. 2012

Clin Exp Otorhinolaryngol

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A 53-year-old woman presented with left mandibular area pain, trismus, and facial numbness that had persisted for 4 years. Physical examination revealed a 3×5 cm, hard, non-tender, and round mass on the left mandibular area. Computed tomography and magnetic resonance imaging revealed an expansile tumor involving the left mandibular ramus and temporomandibular joint area with bone destruction, extending to the base of middle cranial fossa and left zygomatic bone. The mass at the segment of left mandible and zygomatic bone, and base of middle cranial fossa was removed. Pathological examination of the mass revealed a giant cell tumor. The defect was reconstructed with iliac bone for the mandible and temporal bone and fascia for the cranial bone and dura. The case is described along with a review of the literature.

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