Synchronous Hodgkin’s Disease and Gastric Adenocarcinoma

Abstract

Background: Adenocarcinoma is the most frequent pathological type of stomach cancer. Hodgkin’s lymphoma is a lymphoproliferative disease arising from lymphoid tissue which is characterized by Reed-Sternberg cells. Synchronous occurrence of these two malignancies has not been reported in the English literature so far. Case: Here we present a 52-year-old male complaining of epigastric pain and fever diagnosed as stomach adenocarcinoma and Hodgkin’s lymphoma. Conclusion: It is thought that this case is the first of a synchronous stomach adenocarcinoma and Hodgkin’s lymphoma encountered in the English literature. It should be kept in mind that second malignancies can be seen in mass lesions in patients diagnosed with cancer.

Synchronous Double Malignant Tumors Consisting of Stomach and Hodgkin’s Lymphoma with Collision between Gastric Adenocarcinoma and Hodgkin’s Lymphoma in the Stomach

“…Synchronous gastric adenocarcinoma and lymphoproliferative disorders have been reported until now, however most of them were combinations with gastric non-HL [10]. Regarding synchronous HL and gastric adenocarcinoma, to our knowledge, only 3 cases have previously been reported in the English literature [1, 8, 9]. Our case appears to be only the fourth reported case of synchronous HL and gastric adenocarcinoma.…”

“…Ikeda et al [7] examined 2,250 patients with stomach cancer who had colorectal and lung cancer metachronously and renal cell carcinoma synchronously. However, synchronous HL and gastric adenocarcinoma have been rarely reported [1, 8, 9]. In addition, both HL and subtype of gastric adenocarcinoma are thought to be related with Epstein-Barr virus (EBV), but this relation is unclear.…”

Concomitant Hodgkin’s lymphoma and gastric adenocarcinoma: a rare coincidence

“…To our knowledge, only two cases of synchronous gastric adenocarcinoma and HL have been reported previously in the English literature [19,20]. Tillawi described a 59-yearold Caucasian man who presented with upper abdominal pain, vomiting and stiff neck.…”

Coexistence Hodgkin’s lymphoma and colonic adenocarcinoma: a case report

“…The correlation of HL and colonic adenocarcinoma has been reported as coexistence [2][3][4]. However, the correlation of HL and gastrointestinal adenocarcinoma has been reported metachronous [6] and synchronous [5]. Coexistence of adenocarcinoma with non-Hodgkin's lymphoma seems much more than Hodgkin's lymphoma.…”

“…Coexistence of adenocarcinoma with non-Hodgkin's lymphoma seems much more than Hodgkin's lymphoma. The occurrence of HL and other malignancies included that gastric adenocarcinoma, small-cell lung cancer, astrocytoma, nonHodgkin's lymphoma, acute megakaryocytic leukemia, cervix carcinoma, and testicular cancer have been reported in the literature [5][6][7][8][9][10][11][12][13].…”