Coexistence Hodgkin’s lymphoma and colonic adenocarcinoma: a case report

Demirci, Umut; Büyükberber, Süleyman; Yılmaz, Güldal; Öztürk, Bayram; Akyürek, Nalân; Yıldız, Ramazan; Tonyali, Onder; Coşkun, Uğur; Benekli, Mustafa

doi:10.1007/s12032-009-9172-5

Cited by 3 publications

(3 citation statements)

References 10 publications

(14 reference statements)

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“…1). [12–262] The data were extracted from the abstract in 34 articles, [17,37–39,64,75,76,78,81,94,97,103,129,134,151,162,166,170,174,176,192,195,212,221,222,229,232,234,251,252,256,260–262] of which 21 were in English, 5 in Japanese, 3 in Spanish, 2 in French, 2 in Chinese, and 1 in Czech.…”

Section: Resultsmentioning

confidence: 99%

Synchronous or collision solid neoplasms and lymphomas: A systematic review of 308 case reports

et al. 2022

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Background: The presence of a lymphoma associated with a solid synchronous neoplasm or collision neoplasm has been rarely in the literature, and a detailed characterization of these cases is lacking to date.Objective: To describe the main clinicopathological features of synchronous/collision tumors.Methods: A systematic search in PubMed, Scielo, and Virtual Health Library literature databases for cases or case series of synchronous or collision lymphoma and other solid neoplasms reported up to March 2021 was performed. Three reviewers independently screened the literature, extracted data, and assessed the quality of the included studies. The systematic review was performed following the Preferred Reporting Items for Systematic Meta-Analyses guidelines.Results: Mean age of patients was 62.9 years (52.9% men). A total of 308 cases were included (62% synchronous and 38% collision). The most frequent location of both synchronous and collision tumors was the gastrointestinal tract with the most common solid neoplasm being adenocarcinoma, and the most frequent lymphoma diffuse large B-cell lymphoma (21.7%) and mucosa-associated lymphoid tissue lymphoma (20.4%). Of the total number of mucosa-associated lymphoid tissue lymphomas and gastric adenocarcinomas, the presence of Helicobacter pylori infection was documented in 47.3% of them. Only 2% of all cases had a previous history of lymphoma. Thus, in most cases (98%), lymphoma was discovery incidentally. In addition, nodal lymphoma was associated with metastasis in 29 (9.4%) cases as collision tumor, most commonly (90%) in locoregional lymph nodes of the solid neoplasm. Conclusions:The frequent association of some type of B-cell lymphoma and adenocarcinoma in synchronous/collision tumors of the gastrointestinal tract points to common pathogenic mechanisms in both neoplasia, particularly related to chronic inflammation in this location. In most cases, lymphoma identified in locoregional lymph nodes or distant of a carcinoma seems to represent an incidental finding during the carcinoma diagnostic/therapeutic approach. A synergy between carcinoma and lymphoma (involving inflammation and immunosuppression mechanisms) may favor tumor progression and dissemination. A better understating of the interactions lymphoma/carcinoma in the setting of synchronous/collision tumors may help to improve patient management and prognosis.

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Section: Resultsmentioning

confidence: 99%

Synchronous or collision solid neoplasms and lymphomas: A systematic review of 308 case reports

et al. 2022

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“…Previous studies have reported the simultaneous occurrence of HL and hematological malignancies such as chronic lymphocytic leukemia, peripheral T-cell lymphoma, or diffuse large B-cell lymphoma [21][22][23][24][25]. Also, Hodgkin lymphoma can be seen as synchronous or metachronous with solid tumors such as testicular germ cell neoplasm, laryngeal squamous cell carcinoma, colon carcinoma, gastric adenocarcinoma and pleomorphic adenoma [26][27][28][29][30][31][32][33].…”

Section: Discussionmentioning

confidence: 99%

Synchronous Occurrence of Hodgkin’s Lymphoma and Lung Cancer

Erdem¹,

Aykaş²,

Göçer³

et al. 2021

annhematoloncol

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Hodgkin lymphoma is an uncommon neoplasm that characterized young age of onset, Hodgkin and Reed-Sternberg (HRS) cells derived from B-lymphocytes and a high cure rate, even when the patient presents with advanced metastatic spread. Lung cancer is the most common cancer worldwide and is still responsible for the most cancer deaths. We present an extremely rare case of coexisting Hodgkin lymphoma and lung cancer in a 67-year-old male patient. He initially presented with chest pain. Pet/ct revealed mass in the right lung and lymph nodes in the neck. Biopsy from the premaxillary lymph node was compatible with classical Hodgkin lymphoma. In terms of second primary malignancy, a biopsy was also performed from the mass in the right lung. Pathology showed a pulmonary adenocarcinoma and a right upper lobectomy was then performed. This patient was treated with gemcitabine plus docetaxel for lung cancer. At the end of treatment pet/ct was complete response including lymph nodes in the neck. Therefore, we did not give any treatment for Hodgkin lymphoma. The patient is still being followed up in remission.

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“…Pathological examination of the neck dissection specimen revealed coincidental mixed cellular type HL [15]. Several authors reported that affecting mesenteric lymph nodes with HL was discovered incidentally at laparotomy for colon carcinoma in the same patient [16][17][18].…”

Section: Discussionmentioning

confidence: 99%

Concomitant Hodgkin’s lymphoma and gastric adenocarcinoma: a rare coincidence

Arslan¹,

Öksüzoğlu²,

Önder³

et al. 2010

Med Oncol

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Gastric adenocarcinomas may be seen together with colon, prostate, breast, liver, lung and gynecological malignancies as synchronous or metachronous cancer. However, Hodgkin's lymphoma (HL) is rarely diagnosed with solid tumors. Herein, a 72-year-old man with both gastric adenocarcinoma and HL has been presented. Mass lesions far away from the primary tumor in cancer patients can be not only the sign of distant metastasis but also another primary malignancy. In the English literature, synchronous gastric adenocarcinoma and HL has been rarely reported, and as far as we know, this is the third case to be reported.

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Coexistence Hodgkin’s lymphoma and colonic adenocarcinoma: a case report

Cited by 3 publications

References 10 publications

Synchronous or collision solid neoplasms and lymphomas: A systematic review of 308 case reports

Synchronous or collision solid neoplasms and lymphomas: A systematic review of 308 case reports

Synchronous Occurrence of Hodgkin’s Lymphoma and Lung Cancer

Concomitant Hodgkin’s lymphoma and gastric adenocarcinoma: a rare coincidence

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