Synchronous granulosa cell tumor of the ovary and endometrial adenocarcinoma

Abuali, Sarah M; Asarian, Armand; Xiao, Philip

doi:10.1093/jscr/rjac109

Cited by 2 publications

(2 citation statements)

References 11 publications

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“…Around 80% of these tumors are estrogen-secretes tumors, and the main symptom is irregular bleeding in the menstrual cycle or heavy menstrual bleeding as a consequence of endometrial hyperplasia ( Szewczuk et al ., 2020 ). Hence, the concomitant presence of endometrial cancer is observed in 5-25% of these patients ( Abuali et al ., 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Complete restoration of fertility in a patient treated for androgen-secreting granulosa cell tumor- Case report

Šepić¹,

Severinski²,

Eminović³

et al. 2023

JBRA

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Case Report A 35-yr-old patient suffering from secondary amenorrhea for two years before she was diagnosed. Secondary amenorrhea occurred after the first normal vaginal delivery, and it was initially associated with breastfeeding and a formerly diagnosed thyroid disease. Transvaginal ultrasound confirmed a tumorous mass of the right ovary. Blood hormone tests detected high serum inhibin B and Anti-Müllerian hormone levels and high androgen level with no signs of virilization. Surgical treatment was indicated for a definitive diagnosis of suspected sex cord-stromal tumor. Right-sided laparoscopic salpingo-oophorectomy was performed, and the histopathological analysis confirmed the diagnosis of granulosa cell tumor adult type. The oncological team recommended adjuvant chemotherapy after the operation, but the patient did not give an informed consent. One month after surgical treatment, spontaneous menstrual bleeding occurred with normalization of sex hormone levels and the menstrual cycle. Nine months after surgical treatment, the patient was examined again due to secondary amenorrhea. Ultrasound confirmed a vital intrauterine pregnancy. The pregnancy course was normal, and the patient had a full-term spontaneous vaginal delivery of her second child. Conclusion Restoration of fertility after a temporary loss due to hormone-secreting granulosa cell tumor is possible after sparing surgical treatment. The role of adjuvant chemotherapy is controversial, particularly in patients with stage I-II disease because of the rarity of this tumor and the absence of prospective randomized studies.

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Section: Discussionmentioning

confidence: 99%

Complete restoration of fertility in a patient treated for androgen-secreting granulosa cell tumor- Case report

Šepić¹,

Severinski²,

Eminović³

et al. 2023

JBRA

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“…If an adult granulosa cell tumor is discovered during surgery, tumor markers may be required. Inhibin B appears to be more reliable than inhibin A, and it is usually raised months before a clinical diagnosis of recurrence [ 4 - 5 ].…”

Section: Introductionmentioning

confidence: 99%

A Rare Case of Granulosa Cell Tumor Associated With Endometrial Carcinoma - A Case Report

Chauhan¹,

Shrivastava²,

Acharya³

et al. 2022

Cureus

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Adult granulosa cell tumors are uncommon ovarian tumors mainly diagnosed after the age of 30, and the average age is roughly 55. Very few cases are associated with endometrial carcinoma. Most of these cases are well-differentiated endometrioid adenocarcinoma with excellent prognosis if found early. Heavy, irregular menstrual bleeding and postmenopausal bleeding are frequent and are caused by endometrial shedding due to unopposed estrogen action for a prolonged period of time.A 65-year-old female para 4, live 4 (P4L4) came with postmenopausal bleeding for six months. Various investigations were done, which revealed endometrial cancer type 1. A staging laparotomy was performed, which showed a right hemorrhagic ovarian mass; on a frozen section, it came to be a granulosa cell tumor.The rare association between granulosa cell tumor and endometrial carcinoma can be diagnosed with a good correlation of clinical, histopathological, and radiological findings.

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Synchronous granulosa cell tumor of the ovary and endometrial adenocarcinoma

Cited by 2 publications

References 11 publications

Complete restoration of fertility in a patient treated for androgen-secreting granulosa cell tumor- Case report

Complete restoration of fertility in a patient treated for androgen-secreting granulosa cell tumor- Case report

A Rare Case of Granulosa Cell Tumor Associated With Endometrial Carcinoma - A Case Report

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