“…244,331,338,344,345,357,358,360,362,363 Four publications (LOE 5) were considered neutral to the PECO question either due to lack of follow-up, multiple possible causes for thrombosis, or reasons other than the presence of a pacemaker that were deemed likely to result in thrombosis (e.g., stenosis). 334,337,339,346 Eighteen studies (1 LOE 3 good, 17 LOE 5 good-fair) were judged to be neutral to the PECO question based on long-term follow-up of dogs after pacemaker implantation without reports of thrombotic complications. 332,333,336,340,342,343,[347][348][349][350][351][352][353][354]356,359,363,364 An experimental (LOE 3) study described 74 dogs with implanted pacemakers (≤180 days).…”