Synchronous bilateral urothelial cancer in a kidney recipient

Abstract

Synchronous bilateral urothelial cancer is very rare. We report a 25-year-old male kidney recipient with Alport syndrome who developed bilateral synchronous urothelial cancer after transplantation. At the age of 16 this patient was referred to our clinic for a kidney transplantation. A living related donor kidney transplantation was performed with cyclosporin-based quadruple immunosuppression. He experienced no acute rejection and his graft function was excellent after transplantation. Nine years after transplantation, he complained of asymptomatic gross hematuria and was diagnosed as having a bilateral urothelial cancer in the native upper urinary tracts. A bilateral total nephroureterectomy was undertaken, and the postoperative pathological diagnosis was advanced bilateral urothelial carcinoma. The patient received adjuvant gemcitabine plus cisplatin chemotherapy at a cisplatin dosage reduced by 50%. After 4 years of followup, he is alive with a functioning graft and no evidence of recurrence.

Tumor urotelial renal bilateral y tumor vesical urotelial, reporte de un caso de triple tumor sincrónico

“…De forma reciente se han descrito neoplasias del tracto urinario superior asociadas a inmunosupresores, sobre todo en pacientes portadores de trasplante renal, presentando una incidencia del 2.2% 6 .…”