Synchronous Bilateral Testicular Germ Cell Tumour: Case Report and Review of the Literature

Abstract

We report a case of a 30 years old male aff ected by synchronous bilateral germ cell tumor with a history of unilateral cryptorchidism; the patient underwent surgical treatment followed by adjuvant radiotherapy on para-aortic and iliac lymphnodes. Patients with synchronous tumors usually present with a higher stage disease in contrast to those with unilateral testicular carcinoma, yet the prognosis remains equally favorable.

Synchronous Bilateral Testicular Tumors with Different Histopathology

“…Bach et al reported in 1983 a large series of BGCT, with the predominant histology type being seminoma (48%), followed by nonseminomatous testis cancer (15%) and nongerm cell tumors (22%), and with different histology (15%) [ 19 ]. Although, synchronous BGCT were once thought to present at a higher stage disease in contrast to those with unilateral testicular cancer [ 4 ], this has not been demonstrated in multiple series reviewed [ 7 ] and this is also presented in our case report. Morales-Barrera et al presented 151 patients with testis cancer.…”

“…The first documented case of bilateral testicular germ cell tumors was reported by Bidard in 1853 [ 16 ]. Since then, many series have been published, showing that synchronous bilateral testicular cancer is a quite rare situation [ 4 ]. One of the largest series was presented by Holzbeierlein et al, with only 10 males out of 3984 having synchronous BGCT [ 12 ].…”

“…Only 1-2% of cases are bilateral at diagnosis. Primary bilateral tumors of the testis may occur metachronously in 80–85% of the cases or synchronously in 15–20% of cases [ 4 ], but tend to be of the same histologic type. We report a case of a young male presented with synchronous bilateral germ cell tumors (BGCT) with different histology; he underwent bilateral orchiectomy followed by adjuvant chemotherapy.…”

“…We report a case of a young male presented with synchronous bilateral germ cell tumors (BGCT) with different histology; he underwent bilateral orchiectomy followed by adjuvant chemotherapy. The treatment of patients with synchronous BGCT is based upon the clinical stage and the histopathological type of the tumors and should not be different from the standard management of unilateral testicular carcinoma [ 4 ].…”

Tumor Testis Methachronous Bilateral Dengan Histopathology Berbeda

“…4 Pasien dengan karsinoma testis dalam satu testis adalah 500-1.000 kali lebih mungkin untuk berkembang menjadi karsinoma testis di testis kontralateral. 5 Tumor sel germinal dari testis yang terjadi secara bilateral adalah entitas yang sangat langka, dan kejadiannya berkisar dari 1% hingga 5% seperti yang diterbitkan sebelumnya dalam seri besar. Mereka terjadi secara metachron pada 80-85% kasus dan serempak pada 15-20% kasus.…”