Synchronization of the menstrual cycle through the use of an oral progestin in the rhesus monkey

Pope, N.S.; Gould, Kenneth G.

doi:10.1016/0093-691x(90)90584-g

Cited by 3 publications

(5 citation statements)

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“…Consistently, Pope and Gould [8] showed that in monkeys which had an active corpus luteum at the beginning of altrenogest treatment, luteolysis occurred at the expected time in the ovarian cycle, and Heikinheimo et al [6] reported that LNG treatment does not interfere with progesterone assays in monkeys. In Experiment 1, the effective and most suitable dose of LNG for control of ovulation was investigated.…”

Section: Discussionmentioning

confidence: 54%

“…There are a few reports showing that progestins are useful for control of ovulation in monkeys. Three out of 4 rhesus monkeys showed ovulation synchrony after daily administration of a progestin, altrenogest, mixed with fruit juice [8], and daily intramuscular injections with LNG [6] or a single subcutaneous injection with danazol [3] inhibited ovulation in cynomolgus monkeys. Although these studies suggested the possibility for that progestins control ovulation, the suitable doses and the effect of the treatment at different phases of the menstrual cycle on the time of ovulation had not been studied.…”

Section: Discussionmentioning

confidence: 99%

“…Menstrual cycle synchronization was attempted by orally administering a progestin, altrenogest, to 4 rhesus monkeys and the possibility of achieving ovulation synchronization was suggested [8]. Daily intramuscular injection with a commonly used progestin contraceptive, levonorgestrel (LNG), inhibited follicular maturation and ovulation in cynomolgus monkeys [6].…”

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confidence: 99%

“…Diets containing a synthetic gestagen, levonorgestrel (LNG) were given daily to normally cycling female monkeys for 2 weeks, and plasma concentrations of estradiol-17β and progesterone were determined by EIA in order to estimate the time of ovulation. Doses of LNG (0, 3.2,8, 20, 50, or 125 µg) were given from Day 2 (Day 0 =the first day of menstruation) through Day 15. The numbers of days from the last administration of LNG to the estimated ovulation in the groups treated with LNG at 20 µg and above were significantly greater than those in the controls, and the values in the group treated with LNG at 50 µg were within a narrow range.…”

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confidence: 99%

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Delay of Ovulation Due to Diets Containing Levonorgestrel in Cynomolgus Monkeys (<i>Macaca fascicularis</i>)

Nakama

Akune

Kawate

et al. 2012

The Journal of Veterinary Medical Science

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ABSTRACT. This study was undertaken to develop a simple and practical method to control the time of ovulation in cynomolgus monkeys. Diets containing a synthetic gestagen, levonorgestrel (LNG) were given daily to normally cycling female monkeys for 2 weeks, and plasma concentrations of estradiol-17β and progesterone were determined by EIA in order to estimate the time of ovulation. Doses of LNG (0, 3.2,8, 20, 50, or 125 µg) were given from Day 2 (Day 0 =the first day of menstruation) through Day 15. The numbers of days from the last administration of LNG to the estimated ovulation in the groups treated with LNG at 20 µg and above were significantly greater than those in the controls, and the values in the group treated with LNG at 50 µg were within a narrow range. In a second experiment, LNG was administered at 50 µg in different phases of the menstrual cycle (16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36), and the results indicated that ovulation occurred more than 12 days after the last administration in all monkeys, and the number of days from the last administration of LNG to the estimated ovulation in the group treated on Days 16-29 (luteal phase) was significantly greater than that in the group treated on Days 23-36. These results indicate that daily provision of a diet containing 50 µg LNG could be applicable for delaying ovulation, and suggest that the total level of (exogenous and endogenous) progestins is critical for determining the length of ovulation delay in cynomolgus monkeys. KEY WORDS: control of ovulation time, levonorgestrel, monkey.doi: 10.1292/jvms.12-0023; J. Vet. Med. Sci. 74(11): 1453-1460, 2012 Monkeys, whose physiological characteristics are close to those of humans, are indispensable experimental animals. In particular, recent safety research using monkeys has contributed to the development of new drugs. Although there is much demand for monkeys as experimental animals, their reproductive efficiency is generally very low.Although estrous cycle manipulation has been used as a research and management tool for studying and maximizing reproductive performance in domestic livestock species [1,2,7], there is little information about control of the ovarian cycle in monkeys. Menstrual cycle synchronization was attempted by orally administering a progestin, altrenogest, to 4 rhesus monkeys and the possibility of achieving ovulation synchronization was suggested [8]. Daily intramuscular injection with a commonly used progestin contraceptive, levonorgestrel (LNG), inhibited follicular maturation and ovulation in cynomolgus monkeys [6]. A single subcutaneous administration of a synthetic progestogen, danazol, induced a prolonged suppression of ovarian cyclicity in cynomolgus monkeys [3]. Although these findings suggest that the use of progestogens is effective for control of ovulation in monkeys, suitable doses and effects of the treatment at different phases during the menstrual cycle had not been studied.This study was performed ...

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Section: Discussionmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Delay of Ovulation Due to Diets Containing Levonorgestrel in Cynomolgus Monkeys (<i>Macaca fascicularis</i>)

Nakama

Akune

Kawate

et al. 2012

The Journal of Veterinary Medical Science

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“…Methods to synchronize menstrual cycles [13,21,76] or to confirm ovulation [39,97,104] have been reported and will be useful for ET.…”

Section: Embryo Transfer (Et)mentioning

confidence: 99%

In Vitro Manipulation of Nonhuman Primate Gametes for Embryo Production and Embryo Transfer.

Sankai

2000

Exp. Anim.

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Abstract:Since nonhuman primates are closely related to humans and share many physical similarities, they are important for use in research areas such as human infectious diseases, reproduction, physiology, endocrinology, metabolism, neurology and longevity. To develop and maintain these animals, we must establish techniques for in vitro manipulation of spermatozoa and eggs. For a decade my research group has been conducting basic research to establish embryo manipulation techniques and to clarify the reproductive phenomena in nonhuman primates. This article summarizes the past research on in vitro manipulation of nonhuman primate gametes, from collection of reproductive cells and in vitro fertilization to the birth of offspring after embryo transfer, as well as the current status of these research areas. The studies summarized here will directly lead to the development of standard techniques for practical and comprehensive use in nonhuman primates.

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Assisted Reproduction in the Great Apes

Gould¹,

Dahl²

1993

In Vitro Fertilization and Embryo Transfer in Primates

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Synchronization of the menstrual cycle through the use of an oral progestin in the rhesus monkey

Cited by 3 publications

References 9 publications

Delay of Ovulation Due to Diets Containing Levonorgestrel in Cynomolgus Monkeys (<i>Macaca fascicularis</i>)

Delay of Ovulation Due to Diets Containing Levonorgestrel in Cynomolgus Monkeys (<i>Macaca fascicularis</i>)

In Vitro Manipulation of Nonhuman Primate Gametes for Embryo Production and Embryo Transfer.

Assisted Reproduction in the Great Apes

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