Synaptophysin and the dopaminergic system in hippocampus are involved in the protective effect of rutin against trimethyltin-induced learning and memory impairment

Zhang, Lei; Zhao, Qi; Chen, Chunhai; Qin, Qizhong; Zhou, Zhou; Yu, Zhengping

doi:10.1179/1476830513y.0000000085

Cited by 19 publications

(7 citation statements)

References 43 publications

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“…Our results are supported by Sasaki et al, that antioxidant lutein attenuated oxidative stress and increased the level of synaptophysin in diabetic mice in an attempt to protect retinal neurons [ 15 ]. In addition, numerous studies found beneficial effects of flavonoids by protecting the synaptic structure and function in the brain by promoting the expression of synaptophysin [ 51 , 52 ]. Therefore, additionally naringenin might also exert neuroprotective action in the diabetic retina by inducing synaptophysin expression.…”

Section: Discussionmentioning

confidence: 99%

Flavonoid Naringenin Attenuates Oxidative Stress, Apoptosis and Improves Neurotrophic Effects in the Diabetic Rat Retina

et al. 2017

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Diabetic retinopathy (DR) is one of the leading causes of decreased vision and blindness worldwide. Diabetes-induced oxidative stress is believed to be the key factor that initiates neuronal damage in the diabetic retina leading to DR. Experimental approaches to utilize dietary flavonoids, which possess both antidiabetic and antioxidant activities, might protect the retinal damage in diabetes. The aim of this study was to investigate the potential protective effects of naringenin in the retina of streptozotocin-induced diabetic rats. Diabetic rats were orally treated and untreated with naringenin (50 mg/kg/day) for five weeks and retinas were analyzed for markers of oxidative stress, apoptosis and neurotrophic factors. Systemic effects of naringenin treatments were also analyzed and compared with untreated groups. The results showed that elevated levels of thiobarbituric acid reactive substances (TBARs) and decreased level of glutathione (GSH) in diabetic rats were ameliorated with naringenin treatments. Moreover, decreased levels of neuroprotective factors (Brain derived neurotrophic factor (BDNF)), tropomyosin related kinase B (TrkB) and synaptophysin in diabetic retina were augmented with naringenin treatments. In addition, naringenin treatment ameliorated the levels of apoptosis regulatory proteins; B cell lymphoma 2 (Bcl-2), Bcl-2 associated X protein (Bax) and caspase-3 in the diabetic retina. Thus, the study demonstrates the beneficial effects of naringenin that possesses anti-diabetic, antioxidant and antiapoptotic properties, which may limit neurodegeneration by providing neurotrophic support to prevent retinal damage in diabetic retinopathy.

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Section: Discussionmentioning

confidence: 99%

Flavonoid Naringenin Attenuates Oxidative Stress, Apoptosis and Improves Neurotrophic Effects in the Diabetic Rat Retina

et al. 2017

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“…As a result, both sevoflurane and desflurane reduced the frequency of spontaneous synaptic currents. Previous studies in animal models have revealed that the loss of synaptophysin or PSD-95 in the cortex results in cognitive decline and behavioral deficits [ 19 – 21 ]. Indeed, exposure to 2.5 % sevoflurane in mice during the early stages of neuronal development results in learning and memory deficits that are accompanied by reduced PSD-95 protein expression in the hippocampus [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

The mitochondrial division inhibitor Mdivi-1 rescues mammalian neurons from anesthetic-induced cytotoxicity

Armstrong

Urrego

et al. 2016

Mol Brain

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BackgroundConcerns have risen regarding the potential side effects of clinical exposure of the pediatric population to inhalational anesthetics, and how they might impact cognitive, learning, and memory functions. However, neither the mechanisms of anesthetic cytotoxicity, nor potential protective strategies, have yet been fully explored. In this study, we examined whether two of the most commonly used inhalational anesthetics, sevoflurane and desflurane, affect neuronal viability and synaptic network assembly between cultured rat cortical neurons.ResultsPrimary rat cortical neuron cultures were exposed to equipotent sevoflurane or desflurane for 1 hour. Neuron viability, synaptic protein expression, mitochondrial morphology, and neurite growth were assayed with immunostaining and confocal microscopy techniques. The effects of anesthetics on the functional development of neural networks were evaluated with whole-cell patch clamp recordings of spontaneous synaptic currents. Our results demonstrate that an acute exposure to sevoflurane and desflurane inhibits the development of neurite processes, impacts the mitochondria, and compromises synaptic proteins - concomitant with a reduction in synaptic function in mature networks. Interestingly, pretreatment of neurons with a mitochondrial division inhibitor (Mdivi-1) not only protected mitochondria integrity but also played a protective role against anesthetic-induced structural and functional neurotoxicity.ConclusionsWe show that Mdivi-1 likely plays a protective role against certain harmful effects of general anesthetics on primary rat neuronal cultures. In addition, Mdivi-1 alone plays a direct role in enhancing growth and modulating synaptic activity. This study highlights the importance of further study into possible protective agents against anesthetic neurotoxicity.

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“…These results suggest that rutin may protect against spatial memory impairment induced by trimethyltin. Synaptophysin and the dopaminergic system may be involved in trimethyltin-induced neuronal damage in the hippocampus (Zhang et al, 2014[ 29 ]).…”

Section: Dear Editormentioning

confidence: 99%

An up-to-date review of rutin and its biological and pharmacological activities

Al-Dhabi

Arasu

Park

et al. 2015

EXCLI Journal; 14:Doc59; ISSN 1611-2156

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Synaptophysin and the dopaminergic system in hippocampus are involved in the protective effect of rutin against trimethyltin-induced learning and memory impairment

Abstract: These results suggest that rutin may protect against spatial memory impairment induced by trimethyltin. Synaptophysin and the dopaminergic system may be involved in trimethyltin-induced neuronal damage in hippocampus.

Cited by 19 publications

References 43 publications

Flavonoid Naringenin Attenuates Oxidative Stress, Apoptosis and Improves Neurotrophic Effects in the Diabetic Rat Retina

Flavonoid Naringenin Attenuates Oxidative Stress, Apoptosis and Improves Neurotrophic Effects in the Diabetic Rat Retina

The mitochondrial division inhibitor Mdivi-1 rescues mammalian neurons from anesthetic-induced cytotoxicity

An up-to-date review of rutin and its biological and pharmacological activities

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