An up-to-date review of rutin and its biological and pharmacological activities

Al-Dhabi, Naïf Abdullah; Arasu, Mariadhas Valan; Park, Chang Ha; Park, Sang Un

doi:10.17179/excli2014-663

Cited by 54 publications

(20 citation statements)

References 29 publications

(29 reference statements)

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“…Rutin (tetrahydroxyflavone) is a citrus bioflavonoid ( Figure 28 ), which is also known as quercetin-3-O-rutinoside, sophorin and rutoside [ 110 , 111 , 112 ]. It is the glycoside combination of flavonol quercetin and disaccharide rutinose, having quercetin with -OH at position C3 substituted with rhamnose and glucose sugar groups.…”

Section: Flavonoids and Structure Activity Relationshipmentioning

confidence: 99%

“…It has been found in citrus fruits, vegetables and plants, such as black tea, green tea, figs and buckwheat, etc. [ 110 , 111 ]. It helps in producing collagen and usage of vitamin C in body.…”

Section: Flavonoids and Structure Activity Relationshipmentioning

confidence: 99%

“…It has been documented to possess several pharmacological actions, i.e., it is neuroprotective, antioxidant, anti-inflammatory and anti-tumor, etc. [ 110 , 111 , 112 ]. According to Machado DG et al, report, rutin isolated from ethanolic extract from aerial parts of Schinus molle L. has shown antidepressant action in forced swim and tail suspension test.…”

Section: Flavonoids and Structure Activity Relationshipmentioning

confidence: 99%

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Emerging Role of Flavonoids as the Treatment of Depression

et al. 2021

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Depression is one of the most frequently observed psychological disorders, affecting thoughts, feelings, behavior and a sense of well-being in person. As per the WHO, it is projected to be the primitive cause of various other diseases by 2030. Clinically, depression is treated by various types of synthetic medicines that have several limitations such as side-effects, slow-onset action, poor remission and response rates due to complicated pathophysiology involved with depression. Further, clinically, patients cannot be given the treatment unless it affects adversely the job or family. In addition, synthetic drugs are usually single targeted drugs. Unlike synthetic medicaments, there are many plants that have flavonoids and producing action on multiple molecular targets and exhibit anti-depressant action by affecting multiple neuronal transmissions or pathways such as noradrenergic, serotonergic, GABAnergic and dopaminergic; inhibition of monoamine oxidase and tropomyosin receptor kinase B; simultaneous increase in nerve growth and brain-derived neurotrophic factors. Such herbal drugs with flavonoids are likely to be useful in patients with sub-clinical depression. This review is an attempt to analyze pre-clinical studies, structural activity relationship and characteristics of reported isolated flavonoids, which may be considered for clinical trials for the development of therapeutically useful antidepressant.

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Section: Flavonoids and Structure Activity Relationshipmentioning

confidence: 99%

Section: Flavonoids and Structure Activity Relationshipmentioning

confidence: 99%

Section: Flavonoids and Structure Activity Relationshipmentioning

confidence: 99%

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Emerging Role of Flavonoids as the Treatment of Depression

et al. 2021

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“…Dahham et al observed that Suramin , a standard drug for carrying out antiangiogenic activity in rats can be substituted by n -hexane BPE. Moreover, BPE phenolic compounds furnish several vital functions such as rutin, and its associated derivatives are linked with antiallergic, antifungal, and potential antimicrobial functions, ferulic acid furnishes skin prevention against various cancer-causing elements and helps in preservation, and dopamine has radical scavenging potential in parallel to gallocatechin gallate and ascorbic acid and is stronger than glutathione, quercetin, and BHT. − In recent years, BP and its extracts have been added in the production of various food products such as noodles, jelly, Indian bread, and packaging films with the properties of lipid oxidation inhibition. , BPE also finds its use in dairy products with potential health benefits. In this regard, Kabir et al witnessed that the incorporation of extract of fully ripe banana ( Musa acuminata ) cv.…”

Section: Other Beneficial Uses Of Bpmentioning

confidence: 99%

Banana Peel: Characteristics and Consideration of Its Extract for Use in Meat Products Preservation: A Review

Manzoor

Ahmad

2021

ACS Food Sci. Technol.

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The huge amount of banana byproducts produced has posed a serious concern in the present times; however, they contain a plethora of valuable nutrients, antimicrobials, and natural antioxidants. Among these, antioxidants are well-known for the prevention of deteriorative oxidative reactions during processing and storage that cause undesirable quality impairment in foods. Moreover, the harmful effects of synthetic antioxidants (both in vitro and in vivo studies) have compelled the urgency to replace them with alternative natural ones, particularly in the meat industries. Hence, the prime focus of this review is to explore the underexplored sources of antioxidants with health benefits that serve as a replacement for their toxic counterparts (synthetic ones). Antioxidant and antimicrobial activities of banana peel are linked to the phenolics present, furnishing various health benefits. Nevertheless, the literature suggests a rise in research using banana peel in foods, for meat products in particular, as antimicrobial agents.

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“…Rutin (RT), also known as vitamin P, is a kind of flavonoid that widely exists in citrus fruits (2.7–8106.7 µg/g), apples (350–4780 μg/g), and tea (303–479 μg/g) [ 4 , 5 , 6 , 7 ]. RT has good antioxidant, free radical scavenging, anti–inflammatory, anti–cancer, antibacterial, cardiovascular, and neuroprotective properties [ 8 ]. However, RT is unstable due to its polyhydroxy structure, which is easily affected by environmental factors such as heat (>75 °C) and pH (strong acid and alkaline conditions); in addition, both the benzene ring and hydroxyl group exist in one molecular structure, resulting in poor solubility of RT [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Rutin–Loaded Zein–Carboxymethyl Starch Nanoparticles

Chen

McClements

et al. 2022

Foods

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In this work, rutin (RT)–loaded zein–carboxymethyl starch (CMS) nanoparticles were successfully prepared by the antisolvent precipitation method. The effect of CMS on composite nanoparticles at different concentrations was studied. When the ratio of zein–RT–CMS was 10:1:30, the encapsulation efficiency (EE) was the highest, reaching 73.5%. At this ratio, the size of the composite nanoparticles was 196.47 nm, and the PDI was 0.13, showing excellent dispersibility. The results of fluorescence spectroscopy, FTIR, XRD, and CD showed that electrostatic interaction, hydrogen bonding, and hydrophobic interaction were the main driving forces for the formation of nanoparticles. It can be seen from the FE–SEM images that the zein–RT–CMS nanoparticles were spherical. With the increase in the CMS concentration, the particles gradually embedded in the cross–linked network of CMS (10:1:50). After RT was loaded on zein–CMS nanoparticles, the thermal stability and pH stability of RT were improved. The results showed that zein–CMS was an excellent encapsulation material for bioactive substances.

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An up-to-date review of rutin and its biological and pharmacological activities

Cited by 54 publications

References 29 publications

Emerging Role of Flavonoids as the Treatment of Depression

Emerging Role of Flavonoids as the Treatment of Depression

Banana Peel: Characteristics and Consideration of Its Extract for Use in Meat Products Preservation: A Review

Preparation and Characterization of Rutin–Loaded Zein–Carboxymethyl Starch Nanoparticles

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