Synaptic Properties of Corticocortical Connections between the Primary and Secondary Visual Cortical Areas in the Mouse

Pasquale, Roberto De; Sherman, S. Murray

doi:10.1523/jneurosci.3664-11.2011

Cited by 86 publications

(90 citation statements)

References 52 publications

(85 reference statements)

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“…Fiorani, et al, 1992;Sugita, 1999;Fitzpatrick, 1996;Muckli and Petro, 2013). There is also in vitro evidence that, in the cortex of mice, V1 and V2 have both driving and modulatory connections in both directions (De Pasquale and Sherman, 2011), as do auditory regions A1 and A2 (Covic and Sherman, 2011). Thus, those studies show that driving and modulatory synapses can be distinguished independently of their position in the network architecture.…”

Section: Contextual Modulation Is Widespread Throughout Many Regions mentioning

confidence: 95%

“…Where this possibility has been studied empirically, however, e.g. in mouse visual (De Pasquale and Sherman, 2011) and auditory (Covic et al, 2011) cortex, all the synaptic connections were categorically either driving or modulatory. Whether there are also cortical synapses in which drive and modulation are combined remains to be seen.…”

Section: Are Drive and Modulation Clearly Distinct?mentioning

confidence: 99%

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On the functions, mechanisms, and malfunctions of intracortical contextual modulation

Phillips

Clark

Silverstein

2015

Neuroscience & Biobehavioral Reviews

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A broad neuron-centric conception of contextual modulation is reviewed and re-assessed in the light of recent neurobiological studies of amplification, suppression, and synchronization. Behavioural and computational studies of perceptual and higher cognitive functions that depend on these processes are outlined, and evidence that those functions and their neuronal mechanisms are impaired in schizophrenia is summarized. Finally, we compare and assess the long-term biological functions of contextual modulation at the level of computational theory as formalized by the theories of coherent infomax and free energy reduction. We conclude that those theories, together with the many empirical findings reviewed, show how contextual modulation at the neuronal level enables the cortex to flexibly adapt the use of its knowledge to current circumstances by amplifying and grouping relevant activities and by suppressing irrelevant activities.

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Section: Contextual Modulation Is Widespread Throughout Many Regions mentioning

confidence: 95%

Section: Are Drive and Modulation Clearly Distinct?mentioning

confidence: 99%

On the functions, mechanisms, and malfunctions of intracortical contextual modulation

Phillips

Clark

Silverstein

2015

Neuroscience & Biobehavioral Reviews

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“…This conclusion should be considered in the context of prior work that shows that activation of certain glutamatergic inputs also downregulates glutamatergic circuits, likewise through activation of mGluRs, although evidence from various sources indicates both presynaptic and postsynaptic involvement of both group I and group II mGluRs in this latter result (De Pasquale and Sherman 2011, 2012, 2013Lee and Sherman 2009a,b). It is interesting in this regard that the available evidence involving a number of examples indicates that activation of the relevant mGluRs always leads to a reduction of synaptic transmission and not an increase.…”

Section: Bimentioning

confidence: 74%

“…We adopted our previously described procedures (De Pasquale and Sherman 2011, 2012, 2013Lam and Sherman 2005;Lee and Sherman 2008;Reichova and Sherman 2004;Theyel et al 2010); these are briefly summarized below. All procedures were approved by the Institutional Animal Care and Use Committee of the University of Chicago.…”

Section: Methodsmentioning

confidence: 99%

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Modulatory effects of activation of metabotropic glutamate receptors on GABAergic circuits in the mouse cortex

Liu

Petrof

Sherman

2014

Journal of Neurophysiology

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Liu T, Petrof I, Sherman SM. Modulatory effects of activation of metabotropic glutamate receptors on GABAergic circuits in the mouse cortex. J Neurophysiol 111: 2287-2297, 2014. First published March 12, 2014 doi:10.1152/jn.00730.2013.-Metabotropic glutamate receptors (mGluRs) have a ubiquitous distribution in the central nervous system and often serve to regulate the release of neurotransmitters. We have previously shown that activation of both presynaptic and postsynaptic mGluRs can affect the gain of glutamatergic inputs in both thalamus and cortex. In the present study, we sought to determine the effect of mGluR activation on GABAergic inputs in cortex. Using whole cell recordings in a mouse slice preparation of either primary visual or auditory cortex (V1 or A1), we tested the effects on mGluRs by applying various agonists to the slice. Two pathways were tested in each area: the GABAergic inputs in layers 2/3 activated from layer 4 and the GABAergic inputs in layer 4 activated from adjacent layer 4. In both of these pathways, we found that activation of mGluRs significantly reduced the amplitude of the evoked inhibitory postsynaptic currents. Because the effects were not blocked by the addition of GDP␤S to the recording electrode, and because mGluR agonists did not affect responses to photostimulation of GABA in a low-Ca 2ϩ and high-Mg 2ϩ bathing solution, we concluded this reduction was due to activation of presynaptic mGluRs. Furthermore, using specific mGluR agonists, we found that group II mGluRs, but not group I mGluRs, were involved in these modulatory effects. Because similar results were found in both pathways in V1 and A1, a possible cortical pattern for these effects is suggested. cortical circuit; GABA; IPSC; mGluR; modulation METABOTROPIC GLUTAMATE RECEPTORS (mGluRs) are G proteincoupled receptors found in many areas of the mammalian brain (Hollmann and Heinemann 1994). Previous work from our laboratory has shown that activation of mGluRs either by agonist application or by stimulation of certain glutamatergic inputs reduces the gain of synaptic transmission in other glutamatergic inputs. Both presynaptic and postsynaptic mGluRs have been implicated in this phenomenon in various combinations [reviewed in Sherman (2014)].Recent studies have indicated the existence of mGluRs on GABAergic terminals, suggesting the possibility that activation of these receptors can modulate GABA release (Cartmell and Schoepp 2000;Pinheiro and Mulle 2008;Schoepp 2001). However, studies that tested this idea have produced a range of results. Activation of group II mGluRs has been shown to suppress GABAergic responses in hippocampus (Jouvenceau et al. 1995;Liu et al. 1993 Given the importance of GABAergic circuitry in cortex (Anderson et al. 2000;DeFelipe 1993;Ferster and Miller 2000;Haglund et al. 1992; Hamberger and van Gelder 1993;Hirsch and Martinez 2006;Marco et al. 1996;Monier et al. 2003;Sherwin 1999;Wood et al. 1979) and given the widespread presence of mGluRs in cortex, we sought to investigate the effects of...

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Morphological and neurochemical comparisons between pulvinar and V1 projections to V2

Marion

Purushothaman

et al. 2013

J of Comparative Neurology

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The flow of visual information is clear at the earliest stages: the retina provides the driving (main signature) activity for the lateral geniculate nucleus (LGN), which, in turn, drives the primary visual cortex (V1). These driving pathways can be distinguished anatomically from other modulatory pathways that innervate LGN and V1. The path of visual information after V1, however, is less clear. There are two primary feedforward projections to the secondary visual cortex (V2), one from the lateral/inferior pulvinar and the other from V1. Because both lateral/inferior pulvinar and V2 can't be driven visually following V1 removal, either or both of these inputs to V2 could be drivers. Retinogeniculate and geniculocortical projections are privileged over modulatory projections by their layer of termination, bouton size, and the presence of vesicular glutamate transporter 2 (Vglut2) or parvalbumin (PV). It has been suggested that such properties might also distinguish drivers from modulators in extrastriate cortex. We tested this hypothesis by comparing lateral pulvinar-to-V2 and V1-to-V2 projections with LGN-to-V1 projections. We found that V1 and lateral pulvinar projections to V2 are similar in that they target the same layers and lack PV. Projections from pulvinar to V2, however, bear a greater similarity to projections from LGN to V1 because of their larger bouton sizes (measured at the same location in V2) and positive staining for Vglut2. These data lend support to the hypothesis that the pulvinar could act as a driver for V2.

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Synaptic Properties of Corticocortical Connections between the Primary and Secondary Visual Cortical Areas in the Mouse

Cited by 86 publications

References 52 publications

On the functions, mechanisms, and malfunctions of intracortical contextual modulation

On the functions, mechanisms, and malfunctions of intracortical contextual modulation

Modulatory effects of activation of metabotropic glutamate receptors on GABAergic circuits in the mouse cortex

Morphological and neurochemical comparisons between pulvinar and V1 projections to V2

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