Symptoms of depression but not anxiety are associated with central obesity and cardiovascular disease in people with type 2 diabetes: the Edinburgh Type 2 Diabetes Study

Labad, Javier; Price, Jackie F.; Strachan, Mark W. J.; Fowkes, F. G. R.; Ding, Jie; Deary, Ian J.; Lee, A. J.; Frier, Brian M.; Seckl, Jonathan R.; Walker, Brian R.; Reynolds, Rebecca M.

doi:10.1007/s00125-009-1628-9

Cited by 60 publications

(35 citation statements)

References 10 publications

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“…Also, in spontaneously diabetic INS2 Akita mouse, Asakawa and colleagues reported anxiety-like behavior using the elevated plus maze test [65]. Labad and colleagues recently have shown that depression but not anxiety is associated with type-2 diabetes [66]. Results of anxiety and depression screening of db/db mice are consistent with this clinical report showing the presence of depression but not anxiety.…”

Section: Discussionsupporting

confidence: 62%

Neurobehavioral deficits in db/db diabetic mice

Sharma¹,

Elased²,

Garrett³

et al. 2010

Physiology & Behavior

150

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Recent clinical studies indicate neurobehavioral disturbances in type-2 diabetics. However, there is paucity of preclinical research to support this concept. The validity of db/db mouse as an animal model to study type-2 diabetes and related complications is known. The present study was designed to investigate comprehensively the db/db mouse behavior as preclinical evidence of type-2 diabetes related major neurobehavioral complications. We tested juvenile (5–6 weeks) and adult (10–11 weeks) db/db mice for behavioral depression in forced swim test (FST), psychosis-like symptoms using pre-pulse inhibition (PPI) test, anxiety behavior employing elevated plus maze (EPM) test, locomotor behavior and thigmotaxis using open field test and working memory deficits in Y-maze test. Both juvenile and adult group db/db mice displayed behavioral despair with increased immobility time in FST. There was an age-dependent progression of psychosis-like symptoms with disrupted PPI in adult db/db mice. In the EPM test, db/db mice were less anxious as observed by increased percent open arms time and entries. They were also hypolocomotive as evident by a decrease in their basic and fine movements. There was no impairment of working memory in the Y-maze test in db/db mice. This is the first report of depression, psychosis-like symptoms and anxiolytic behavior of db/db mouse strain. It is tempting to speculate that this mouse strain can serve as useful preclinical model to study type-2 diabetes related neurobehavioral complications.

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Section: Discussionsupporting

confidence: 62%

Neurobehavioral deficits in db/db diabetic mice

Sharma¹,

Elased²,

Garrett³

et al. 2010

Physiology & Behavior

150

View full text Add to dashboard Cite

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“…However, most of the studies have only evaluated indirect measurements of adiposity, such as BMI and WC [5-8]. These anthropometric variables, although largely used in clinical practice, may neither indicate the total body fat nor differentiate lean from fat mass.…”

Section: Discussionmentioning

confidence: 99%

Body composition and depressive/anxiety symptoms in overweight and obese individuals with metabolic syndrome

Guedes

Madeira

Mafort

et al. 2013

Diabetol Metab Syndr

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Background: Several studies point to a correlation between obesity and the severity of depressive and anxiety symptoms in children and adults, but there are still some controversial points about this association. The aim of this study is to investigate the relationship between body composition and the severity of anxiety/depressive symptoms in overweight and obese individuals with Metabolic Syndrome (MS). Methods: Fifty patients, 18-50 years old, overweight or obese and with the diagnosis of MS based on the International Diabetes Federation (IDF) criteria were selected for this study. Body composition was evaluated using Dual Energy X-ray Absorptiometry (DXA). Depressive symptoms were evaluated using the Hospital Anxiety and Depression Scale (HADS-Depression) and the Beck Depression Inventory (BDI). Anxiety symptoms were evaluated using HADS-Anxiety. Results: No correlation was found between depressive symptoms (HADS-Depression or BDI) and Body Mass Index (BMI) (r = 0.01; p = 0.94 and r = −0.12, p = 0.38; respectively), Waist Circumference (WC) (r = −0.06, p = 0.67 and r = −0.22, p = 0.12; respectively), and Waist-to-Hip Ratio (WHR) (r = −0.12, p = 0.40 and r = −0.17, p = 0.23; respectively). Additionally, no correlation was found among anxiety symptoms (HADS-Anxiety) and BMI (r = −0.15, p = 0.27), and WHR (r = −0.17, p = 0.24). In contrast, a significant correlation was found between percentage of total fat (DXA) and HADS-Depression (r = 0.34, p = 0.019) and HADS-Anxiety (r = 0.30, p = 0.039). Additionally, an inverse and strong correlation was found between lean mass (in grams) and HADS-Depression (r = −0.42, p = 0.004), HADS anxiety (r = −0.57, p < 0.0001), and BDI (r = −0.44, p = 0.026). Conclusions: In individuals with MS, the percentage of body fat, and not central fat, BMI, WC, or WHR, was associated with an increased severity of anxiety and depressive symptoms. In contrast, total lean mass was strongly associated with fewer anxiety/depressive symptoms, suggesting that body composition might be related to psychiatric comorbidity in overweight individuals with MS.

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“…In addition, anxiety has been found to be associated with lifetime severe hypoglycemia, but not abdominal obesity or cardiovascular disease, in longitudinal analysis [38]. Overall, these recent studies continue to show a relationship between anxiety and diabetes, although the strength of the associations is weaker than those found for the association between diabetes and depression.…”

Section: Association Between Anxiety and Diabetes Outcomesmentioning

confidence: 95%

Serious Psychological Distress and Diabetes: A Review of the Literature

Egede

Dismuke

2011

Curr Psychiatry Rep

109

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With the development of a measure of serious psychological distress (SPD) in 2002, more attention is being paid to the association of SPD with diabetes outcomes and processes of care. We review the literature on the relationship between SPD and diabetes processes of care and outcomes, as well as the literature on the relationship between specific mental health diagnoses and diabetes processes of care and outcomes during the 2010 to 2011 period. There is an extensive literature on the association of mental health diagnoses with diabetes outcomes, especially for depression. Because the Kessler scale measures a much broader range of mental health issues than any specific DSM-IV/Structured Clinical Interview for DSM Disorders diagnosis and is designed to assess SPD at the population level, additional research needs to be conducted both in clinical settings and using large administrative datasets to examine the association between SPD and diabetes outcomes and processes of care.

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Symptoms of depression but not anxiety are associated with central obesity and cardiovascular disease in people with type 2 diabetes: the Edinburgh Type 2 Diabetes Study

Cited by 60 publications

References 10 publications

Neurobehavioral deficits in db/db diabetic mice

Neurobehavioral deficits in db/db diabetic mice

Body composition and depressive/anxiety symptoms in overweight and obese individuals with metabolic syndrome

Serious Psychological Distress and Diabetes: A Review of the Literature

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