Symptoms of and Palliative Treatment for Unresectable Skin Cancer

Goto, Hiroyuki; Kiyohara, Yoshio; Shindo, Masahisa; Yamamoto, Osamu

doi:10.1007/s11864-019-0626-5

Cited by 9 publications

(8 citation statements)

References 57 publications

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“…80 There is very limited literature focusing on palliative care in dermato-oncology. 81 If regional metastases are diagnosed, intensive surgical treatment and/or radiation therapy is advised as curative treatment. Pretreatment selection of patients eligible for this intensive treatment is challenging.…”

Section: Discussionmentioning

confidence: 99%

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Treatment of keratinocyte carcinoma in elderly patients – a review of the current literature

Leus

Frie

Haisma

et al. 2020

Acad Dermatol Venereol

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A large percentage of the patients with keratinocyte carcinoma (KC, formerly known as non‐melanoma skin cancer) is of advanced age and often too frail for standard therapies. However, no specific treatment recommendations are given for this population. This review aimed to give an overview of the current literature on the best practice for the treatment of elderly patients with KC. A literature search was performed in MEDLINE, using ‘keratinocyte carcinoma’, ‘elderly’, ‘treatment’ and various synonyms. Case reports, reviews, comments, non‐English literature and studies with a sample size <15 were excluded. After selection, a total of 47 studies were reviewed. Two types of studies were identified, focusing on (I) the effect of age on treatment outcomes and (II) alternative treatment schedules for elderly patients. Studies on surgery, the gold standard, describe larger lesions and defect size in the elderly population. Recurrence rate, complication rate and disease‐specific survival were not affected by age. Depending on the expected morbidity of a suggested (re‐)excision and patient preferences, a conservative watchful waiting policy can be agreed upon as a shared decision. Other common treatment modalities, such as adjuvant radiotherapy, photodynamic therapy and systemic therapy for basal cell carcinoma (BCC), show comparable results in the elderly and younger population. Alternative treatment schedules for elderly patients include primary hypofractionated radiotherapy, which seems effective and well‐tolerated, although research is limited to case series. Additionally, localized and topical treatments seem safe and effective especially for low‐risk tumours. Data are lacking on the efficacy of systemic therapies of metastatic KC in elderly patients. Efficacy of most treatments (with the exception of photodynamic therapy) is not dependent on age. There is need for more research on the efficacy of adjusted treatment modalities, such as hypofractionated radiotherapy and palliative or curative systemic treatment.

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Section: Discussionmentioning

confidence: 99%

“…Supporting the patient in living life with as less limitations as possible is the main purpose . There is very limited literature focusing on palliative care in dermato‐oncology …”

Section: Discussionmentioning

confidence: 99%

Treatment of keratinocyte carcinoma in elderly patients – a review of the current literature

Leus

Frie

Haisma

et al. 2020

Acad Dermatol Venereol

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“…The most commonly used approach for diagnosing irregular moles and pigmented lesions as melanoma is the ABCDE method, which stands for "Asymmetry, Border irregularity, Color variation, Diameter and Evolving" [11]. Symptoms of advanced melanoma include anorexia, bleeding, pain, and fatigue, among others [17].…”

Section: Introductionmentioning

confidence: 99%

A Cross-Sectional Survey of Knowledge of Skin Cancer in Saudi Arabia

Al-Atif

2021

Dermatol Pract Concept

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Background: Skin cancer has become one of the world’s leading health problems, and incidence rates are on the rise. The leading causes of skin cancer are sun exposure, family history and sunburn, and the most agreed-upon preventative behaviors are sunscreen application and sun avoidance. Objectives: This study assessed the knowledge of the causes of skin cancer and awareness of preventative measures in Saudi Arabia. Methods: A cross-sectional study was conducted among 529 participants in a WhatsApp group over 3 months. Consenting participants completed a validated, 18-item questionnaire. Results: Of 529 total participants, nearly 55% of participants reported an awareness of skin cancer, 35% understood its metastasis and 55.1% knew about its spread. However, 44% of participants were unaware of the different types of the disease. Social media was reported to be the most common source of information. The majority of participants were able to identify symptoms of skin cancer and had knowledge of risk factors. Most participants understood proper preventative measures, and reported that they use sunscreen regularly. Conclusions: The general knowledge of skin cancer in Saudi Arabia is not high but is increasing. However, sun-protective behaviors are lacking, despite the population’s knowledge of the benefits. Awareness campaigns and incentive programs may encourage better preventative behavior. Future studies should explore participants’ awareness of more specific aspects of skin cancer using a more diverse and extensive population sample.

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“…5 Several studies such as those by Von Gunten and Gafford (2013), Goto (2019), Kumar and Panda (2014), and Lowey (2017) concluded that the use of AN does not, by itself, reverse anorexia and can worsen the QOL of patients, mainly in the terminal stage, due to the occurrence of complications such as nausea and vomiting, diarrhea, aspiration, dyspnea, edema, increased incidence of infections, and mechanical complications. 28,8,26,15…”

Section: Non-pharmacological Managementmentioning

confidence: 99%

Management Approach for Anorexia in Palliative Care: An Integrative Literature Review

Moura

Melo

Chaves

et al. 2020

R.pesq.:cuid.fundam.Online

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Objetivo: Identificar as evidências científicas acerca das condutas para o manejo da anorexia em cuidados paliativos. Métodos: Trata-se de uma revisão integrativa, cujo levantamento bibliográfico dos dados deu-se através da pesquisa em quatro bases de dados/bibliotecas virtuais. Incluíram-se artigos em português, inglês e espanhol, publicados nos últimos dez anos e com o texto completo disponível. Resultados: Foram elegíveis 25 artigos, e foram atribuídos dois eixos temáticos para melhor ilustrar os dados encontrados: o manejo farmacológico e o não-farmacológico. Corticosteroides, progestinas, anamorelina e dronabinol foram os fármacos mais pesquisados para o controle da anorexia, com maiores evidências de eficácia nos 3 primeiros. No contexto não-farmacológico, o aconselhamento nutricional foi a medida mais indicada, incluindo a fortificação de alimentos e uso de suplementos e a nutrição artificial mais controversa. Conclusão: Os achados desta revisão podem colaborar para a elaboração de protocolos para o manejo da anorexia em cuidados paliativos.

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Symptoms of and Palliative Treatment for Unresectable Skin Cancer

Cited by 9 publications

References 57 publications

Treatment of keratinocyte carcinoma in elderly patients – a review of the current literature

Treatment of keratinocyte carcinoma in elderly patients – a review of the current literature

A Cross-Sectional Survey of Knowledge of Skin Cancer in Saudi Arabia

Management Approach for Anorexia in Palliative Care: An Integrative Literature Review

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