Symptoms in peri- and postmenopausal women in relation to testosterone concentrations: data from The Women's Health in the Lund Area (WHILA) study

Götmar, Anders; Hammar, Mats; Fredrikson, Mats; Samsioe, Göran; Nerbrand, Christina; Lidfeldt, Jonas; Spetz, Anna-Clara

doi:10.1080/13697130802249769

Cited by 9 publications

(2 citation statements)

References 57 publications

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“…In this respect, steroids have emerged as interesting candidates since they represent a large family of circulating mediators with important biological roles. Interestingly, epidemiological studies have indicated that among men lower testosterone (TST) concentrations may be associated with increased cold sensitivity, 7 while fluctuations in TST concentrations in a population of Norwegian men has been linked to variations in ambient temperature 8 . In addition, androgens are not only known to increase TRPM8 expression in prostate tissue 9,10 but TST has also recently been shown to rapidly modulate channel activity in vitro 11‐13 .…”

Section: Introductionmentioning

confidence: 99%

Testosterone‐androgen receptor: The steroid link inhibiting TRPM8‐mediated cold sensitivity

et al. 2020

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Recent studies have revealed gender differences in cold perception, and pointed to a possible direct action of testosterone (TST) on the cold‐activated TRPM8 (Transient Receptor Potential Melastatin Member 8) channel. However, the mechanisms by which TST influences TRPM8‐mediated sensory functions remain elusive. Here, we show that TST inhibits TRPM8‐mediated mild‐cold perception through the noncanonical engagement of the Androgen Receptor (AR). Castration of both male rats and mice increases sensitivity to mild cold, and this effect depends on the presence of intact TRPM8 and AR. TST in nanomolar concentrations suppresses whole‐cell TRPM8‐mediated currents and single‐channel activity in native dorsal root ganglion (DRG) neurons and HEK293 cells co‐expressing recombinant TRPM8 and AR, but not TRPM8 alone. AR cloned from rat DRGs shows no difference from standard AR. However, biochemical assays and confocal imaging reveal the presence of AR on the cell surface and its interaction with TRPM8 in response to TST, leading to an inhibition of channel activity.

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Section: Introductionmentioning

confidence: 99%

Testosterone‐androgen receptor: The steroid link inhibiting TRPM8‐mediated cold sensitivity

et al. 2020

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“…No significant differences between continent and incontinent women was found regarding serum levels of cortisol, T, androstenedione, or T and androstenedione combined. Gotmar et al found that lower T concentrations were associated with lower quality of life in peri‐menopausal women. Kwon et al performed a preliminary study about voiding characteristics and related hormonal changes in peri‐ and post‐menopausal women.…”

Section: Introductionmentioning

confidence: 99%

Is testosterone important in LUT function in men and women? ICI‐RS 2015

Badawi

Bosch

Djurhuus

et al. 2017

Neurourology and Urodynamics

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Reproductive Hormone Influences on Thermoregulation in Women

Charkoudian

Stachenfeld

2014

Comprehensive Physiology

106

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The present discussion reviews current knowledge regarding influences of the primary reproductive hormones on mechanisms of thermoregulatory control in women. The human body is remarkably capable of maintaining body temperature within a few tenths of a degree of normal (37°C) over a wide range of activity and environmental exposures; this regulation is accomplished via integration of central and peripheral thermal information at the preoptic area of the anterior hypothalamus (PO/AH). We describe both central and peripheral mechanisms involved in controlling thermoregulation in humans, and how these mechanisms are affected by sex and hormone exposure. Estrogens generally promote vasodilation, heat dissipation, and lower body temperature and progesterone or progestins generally have the opposite effect. Estrogens and progesterone/progestins can also interact with androgens; this is an important point because androgens in the body can increase in both older and younger women. The study of reproductive hormone (estrogens, progesterone, luteinizing, and follicle stimulating hormones) effects on body systems is challenging because of the complex and multifaceted influences of these hormones, both individually and in combination. Thus, a number of methods to alter hormone exposure are explained in this article. We conclude that men and women do not exhibit major quantitative differences in physiological thermoregulatory responses to exercise and/or body heating when factors such as fitness and body size are taken into account. However, female and male reproductive hormones have important influences that can significantly alter individual thermoregulatory responses at various points throughout the lifespan.

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Symptoms in peri- and postmenopausal women in relation to testosterone concentrations: data from The Women's Health in the Lund Area (WHILA) study

Cited by 9 publications

References 57 publications

Testosterone‐androgen receptor: The steroid link inhibiting TRPM8‐mediated cold sensitivity

Testosterone‐androgen receptor: The steroid link inhibiting TRPM8‐mediated cold sensitivity

Is testosterone important in LUT function in men and women? ICI‐RS 2015

Reproductive Hormone Influences on Thermoregulation in Women

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