Symptoms and impacts in anemia of chronic kidney disease

Mathias, Susan D.; Blum, Steven I.; Sikirica, Vanja; Johansen, Kirsten L.; Colwell, Hilary H.; Okoro, Tony

doi:10.1186/s41687-020-00215-8

Cited by 17 publications

(6 citation statements)

References 15 publications

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“…The Physical function scales and the FACIT-An Total, Fatigue and Anaemia scales, are also reliable and valid measures for assessing health-related quality of life in anaemia associated with CKD [ 41 ]. Patient reported outcome measures are being developed [ 42 , 43 ]. However, the chronic kidney disease Anaemia Questionnaire (CKD-AQ) is the latest advance and appears to be a reliable and sound patient-related outcome measure for use in patients with anaemia of CKD [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

Predictors of quality of life in patients within the first year of commencing haemodialysis based on baseline data from the PIVOTAL trial and associations with the study outcomes

et al. 2023

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Background Impaired quality of life is common in patients with end-stage kidney disease. We report the baseline quality of life measures in participants from the PIVOTAL randomized controlled trial and the potential relationship with the primary outcome (all-cause mortality, myocardial infarction, stroke, and heart failure hospitalisation), and associations with key baseline characteristics. Methods This was a post hoc analysis of 2141 patients enrolled in the PIVOTAL trial. Quality of life was measured using EQ5D index, Visual Analogue Scale, and the KD-QoL [Physical Component Score and Mental Component Score]. Results Mean baseline EQ5D index and visual analogue scale scores were 0.68 and 60.7 and 33.7 (Physical Component Score) and 46.0 (Mental Component Score), respectively. Female sex, higher Body Mass Index, diabetes mellitus, history of myocardial infarction, stroke or heart failure were associated with significantly worse EQ5D index and visual analogue scale. Higher C-reactive protein levels and lower transferrin saturation were associated with worse quality of life. Haemoglobin was not an independent predictor of quality of life. A lower transferrin saturation was an independent predictor of worse physical component score. A higher C-reactive protein level was associated with most aspects of worse quality of life. Impaired functional status was associated with mortality. Conclusion Quality of life was impaired in patients starting haemodialysis. A higher C-reactive protein level level was a consistent independent predictor of the majority of worse quality of life. Transferrin saturation ≤ 20% was associated with worse physical component score of quality of life. Baseline quality of life was predictive of all-cause mortality and the primary outcome measure. EudraCT registration number 2013-002267-25. Graphical abstract Supplementary Information The online version contains supplementary material available at 10.1007/s40620-023-01571-6.

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Section: Discussionmentioning

confidence: 99%

Predictors of quality of life in patients within the first year of commencing haemodialysis based on baseline data from the PIVOTAL trial and associations with the study outcomes

et al. 2023

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“…Адже чим старший вік, тим коморбідні пацієнти зустрічаються все частіше. Ризик госпіталізацій та кардіоваскулярних подій також може збільшуватися зі зростанням кількості хронічних патологічних станів у пацієнта [4][5][6][7][8][9][10][11][12][13][14][15].…”

Section: вплив донаторів оксиду азоту на клінічний перебіг ішемічної ...unclassified

Influence of Nitric Oxide Donors on the Clinical Course of Coronary Heart Disease with Concomitant Anemia

Ханюков¹,

Zayats²

2022

Ukr. ž. med. bìol. sportu

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The purpose of the study was to evaluate the effect of L-arginine on the general condition of patients with coronary artery disease and anemia, on the dynamics of laboratory parameters of iron metabolism, glucose, high-sensitivity C-reactive protein, lipid metabolism and the functional state of the kidneys in particular category of patients. Materials and methods. The study involved 53 patients with coronary heart disease and anemia, aged from 56 to 85 years. The patients were randomized into two groups. The control group included 24 patients who received standard therapy for coronary heart disease and anemia. The main group included 29 patients who, in addition to standard therapy, received L-arginine intravenously and orally according to the scheme. Results and discussion. As a result of treatment, red blood counts and iron metabolism in the main and control groups normalized. A comparative analysis of iron metabolism indicators showed that during treatment, patients who received L-arginine had a more active metabolism and accumulation of iron in the body. Restoration of hemoglobin levels in patients with coronary heart disease and anemia contributed to the improvement of the general condition and well-being in both groups. But general weakness (p<0.001) and palpitations (p<0.05) after treatment were less pronounced in the main group. Observations showed the dynamics of high-sensitivity C-reactive protein, indicators of lipid metabolism and the functional state of the kidneys in the main and control groups. A significant decrease in lipidogram parameters after treatment was noted both in patients of the control and the main group; but due to the addition of L-arginine, changes in total cholesterol, high density lipoprotein and atherogenic index in the main group compared with the control group were more pronounced (from p<0.01 to p<0.001). The inclusion of statins in the standard therapy contributed to a significant decrease in the levels of high-sensitivity C-reactive protein in patients in the main group – 17.8% (p<0.001) and 11.4% (p<0.05) in the control group. Conclusion. According to the results of the study, it was found that nitric oxide donors have a beneficial effect on iron metabolism, lipid profile, high-sensitivity C-reactive protein level, the functional state of the kidneys, and, probably, on the degree of heart failure. It has been established that against the background of treatment with L-arginine, the bioavailability of orally incoming iron increases; the supply of iron in the body increases significantly; there was a trend towards normalization of lipid profile and functional state of the kidneys with significant changes in creatinine and glomerular filtration rate levels; decrease in signs of heart failure (general weakness, palpitations)

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“…В обсерваційному дослідженні серед 11 265 пацієнтів із 13 академічних лікарень Нью-Йорка, госпіталізованих з 1 березня по 27 квітня 2020 року, підвищення рівня D-димера було пов'язане з більш низьким медіанним рівнем гемоглобіну й більш високим рівнем феритину сироватки крові. Аналогічна ситуація відмічалась у пацієнтів із COVID-19 і ГУН, і в пацієнтів на програмному діалізі [17,18]. У пацієнтів із тяжкою формою COVID-19 часто спостерігається інтенсивна запальна фаза і протромботичний стан.…”

Section: інші варіанти стимуляції еритропоезуunclassified

Management of anemia in chronic kidney disease

Kushnirenko

2021

KIDNEYS

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Symptoms and impacts in anemia of chronic kidney disease

Cited by 17 publications

References 15 publications

Predictors of quality of life in patients within the first year of commencing haemodialysis based on baseline data from the PIVOTAL trial and associations with the study outcomes

Predictors of quality of life in patients within the first year of commencing haemodialysis based on baseline data from the PIVOTAL trial and associations with the study outcomes

Influence of Nitric Oxide Donors on the Clinical Course of Coronary Heart Disease with Concomitant Anemia

Management of anemia in chronic kidney disease

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