Symptoms After Primary Immunisation With DTP and With Dt Vaccine

Feasibility study for identifying adverse events attributable to vaccination by record linkage

“…Despite the small size of our study, the absolute risks of a convulsion after a third dose of DTP vaccine of 1 in 9800 approximately, and of a convulsion 6-11 days after MMR vaccine of 1 in 2850 (matched admissions only) were consistent with other estimates [2]. The absence of admissions for collapse, which have been reported after American DTP vaccines in association with pyrexia [5], is consistent with an earlier study of British DTP vaccine in which recipients were actively followed up after each dose [6].…”

Adverse effects and sero-responses to an acellular pertussis/diphtheria/tetanus vaccine when combined with Haemophilus influenzae type b vaccine in an accelerated schedule

“…The Hib vaccine is unlikely to have contributed substantially to higher rates for the last dose of the acellular combination as reactions to a third dose of PRP-T are uncommon in this schedule [4,11]. Diphtheria or tetanus toxoids may play a part in local reactions to DTaP vaccines [29,37]. Alternatively, reactions may derive from an immunological response to PT or FHA [20,27] or from vaccine adjuvants or preservatives.…”

Eighty-Kilodalton N-Terminal Moiety of Bordetella pertussis Filamentous Hemagglutinin: Adherence, Immunogenicity, and Protective Role

“…Inactivated whole-cell vaccines (WCVs) have been used for more than 30 years and have successfully reduced the incidence of pertussis (11). However, some adverse side effects have been associated with the administration of WCVs (30), and these have led to development of new, acellular vaccines (ACVs). The safety and reduced reactogenicity of ACVs compared to WCVs have been well established by their extensive use in Japan (15) and by several clinical trials (7,10).…”